Fresh red raspberry phytochemicals suppress the growth of hepatocellular carcinoma cells by PTEN/AKT pathway [0.03%]
新鲜红树莓植物化学物质通过PTEN/AKT途径抑制肝癌细胞增殖
Haopeng Zhang,Jiaren Liu,Guodong Li et al.
Haopeng Zhang et al.
The red raspberry (Rubus idaeus L.) is a common fruit worldwide and its extract has been found to inhibit the growth of many types of tumors, mainly because it is rich in bioactive phytochemicals. However, the mechanism underlying its antic...
Sphingolipids modulate docking, Ca2+ sensitivity and membrane fusion of native cortical vesicles [0.03%]
鞘脂调控原生皮质囊泡的对接、Ca2+敏感性和膜融合
Prabhodh S Abbineni,Jens R Coorssen
Prabhodh S Abbineni
Docking, priming, and membrane fusion of secretory vesicles (i.e. regulated exocytosis) requires lipids and proteins. Sphingolipids, in particular, sphingosine and sphingosine-1-phosphate, have been implicated in the modulation of exocytosi...
Pulmonary arterial hypertension: New pathophysiological insights and emerging therapeutic targets [0.03%]
肺动脉高压：新的病理生理学见解和新兴的治疗靶点
Alice Bourgeois,Junichi Omura,Karima Habbout et al.
Alice Bourgeois et al.
Pulmonary arterial hypertension (PAH) encompasses a group of clinical entities characterized by sustained vasoconstriction and progressive vascular remodeling that act in concert to elevate pulmonary vascular resistance. The current treatme...
Dynamic transcriptome profile in db/db skeletal muscle reveal critical roles for long noncoding RNA regulator [0.03%]
1型糖尿病肌肉长链非编码RNA表达谱及功能分析
Na Zhang,Yahui Zhou,Qingxin Yuan et al.
Na Zhang et al.
T2DM is a global health problem that seriously lowers the quality of life and insulin resistance makes a considerable contribution to the pathophysiology of T2DM. Long noncoding RNAs (lncRNAs) have emerged as important regulators in glucose...
Long non-coding RNA NIFK-AS1 inhibits M2 polarization of macrophages in endometrial cancer through targeting miR-146a [0.03%]
长链非编码RNA NIFK-AS1通过靶向miR-146a抑制子宫内膜癌巨噬细胞M2极化作用
Yun-Xiao Zhou,Wei Zhao,Li-Wei Mao et al.
Yun-Xiao Zhou et al.
Accumulating evidence suggested that tumor-associated macrophages played crucial roles in the progression of endometrial cancer. The aim of this study was to determine the role of lncRNA NIFK-AS1 in M2-like polarization of macrophages and f...
Transglutaminase 3 contributes to malignant transformation of oral leukoplakia to cancer [0.03%]
谷氨酰胺转胺酶3促进口腔黏膜白斑的恶性转化
Xiangbing Wu,Rongyan Wang,Jiantong Jiao et al.
Xiangbing Wu et al.
Oral leukoplakia (OL) is the most common premalignancy in the oral cavity. The objective of this study was to investigate the biological role of transglutaminase 3 (TGM3) in malignant transformation of OL and its clinical value for predicti...
PES1 is transcriptionally regulated by BRD4 and promotes cell proliferation and glycolysis in hepatocellular carcinoma [0.03%]
PES1通过BRD4调控并促进肝癌细胞增殖和糖酵解
Ping Fan,Bo Wang,Zibo Meng et al.
Ping Fan et al.
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. However, the mechanism underlying the tumorigenesis of HCC is still unclear. Improper recruitment of Pescadillo homologue 1 (PES1) can lead to tu...
Role of tumor microenvironment in cancer stem cell chemoresistance and recurrence [0.03%]
肿瘤微环境在癌症干细胞耐药和复发中的作用
Madhurima Das,Sujata Law
Madhurima Das
Chemoresistance to the anticancer therapy is the main challenge for the recurrence of cancer and it is responsible for treatment failure and unfavorable clinical outcome. Understanding the mechanisms of chemoresistance in cancer would help ...
Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-κB axis: Shedding new light on resistance to Aprepitant [0.03%]
神经激肽1受体(NK1R)抑制通过限制NF-κB轴增强三氧化二砷对APL细胞的抗肿瘤作用：为克服阿普利匹坦耐药提供新思路
Davood Bashash,Ava Safaroghli-Azar,Samaneh Bayati et al.
Davood Bashash et al.
While a batch of efforts are fastened on synthesizing the novel targeted anti-cancer agents, recent investigations have achieved a breakthrough in identifying a favorable anti-tumor activity for some supportive drugs, which their safety hav...
The long non-coding RNA LINC01606 contributes to the metastasis and invasion of human gastric cancer and is associated with Wnt/β-catenin signaling [0.03%]
长非编码RNA LINC01606通过Wnt/β-连环蛋白信号通路促进人类胃癌的转移和侵袭
Yajun Luo,Wang Tan,Weikun Jia et al.
Yajun Luo et al.
The dysregulation of long non-coding RNA (lncRNA) has increasingly been linked to human gastric cancer (GC). However, the LINC01606 expression level and clinical values, and its role in the molecular mechanism underlying GC remain largely u...