MFN2 interacts with phosphorylated AMPK to mediate mitophagy in MCF-7 cells [0.03%]
MFN2通过与磷酸化AMPK相互作用介导MCF-7细胞的线粒体自噬
Shixian Zhai,Zihong Huang,Chunchun An et al.
Shixian Zhai et al.
Mitofusin 2 (MFN2) has been reported to play an important role in mitophagy, but how MFN2 mediates mitophagy remains incompletely understood. Here, we establish that MFN2 upregulation is a key driver of mitophagy in MCF-7 cells. MFN2 overex...
CircTHBS1 aggravates peritoneal fibrosis by sponging miR-18a-5p and interacting with CTGF [0.03%]
Circular RNA Circthbs1通过海绵吸附miR-18a-5p及与CTGF互作加重腹膜纤维化
Yanhong Guo,Silu Zhao,Xuewen Zhang et al.
Yanhong Guo et al.
Background: Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis (PD). Previous studies have demonstrated that circular RNAs (circRNAs) play an important role in organ fibrosis. However, whether ...
Comparison of disruption methods to optimize the evaluation of mitochondrial enzymatic activities in human fibroblasts [0.03%]
比较不同的破碎方法以优化人成纤维细胞线粒体酶活性的评估
María Alejandra Sánchez-Muñoz,Adriana Castillo-Villanueva,Marcia Rosario Pérez-Dosal et al.
María Alejandra Sánchez-Muñoz et al.
Mitochondriopathies often lead to chronic degenerative pathology. Muscle biopsy is considered the gold standard for diagnosis; however, its invasiveness restricts the amount of tissue obtained, and issue that is limiting for prospective, lo...
Fetal Muscle Stem Cell-Derived Exosomes Improve Dexamethasone-Induced Muscle Atrophy at the Single Muscle Fiber Level [0.03%]
胎肌干细胞来源的外泌体改善地塞米松引起的单个肌肉纤维萎缩
Qing-Xin Wei,Nasar Khan,Xi-Jun Yin
Qing-Xin Wei
This study investigated the therapeutic potential of exosomes derived from fetal muscle stem cells (FMSC-Exos) in mitigating dexamethasone (DEX)-induced muscle atrophy in a mouse model. Kunming (KM) mice were utilized to visualize muscle at...
Xiaoyou Decoction suppresses cervical precancerous lesions through the activation of cellular autophagy and the upregulation of p53 expression [0.03%]
消郁汤通过激活细胞自噬和上调p53表达抑制宫颈癌前病变
Yang Li,Jingjing Zhao,Mubai Li et al.
Yang Li et al.
Background: Persistent high-risk human papilloma virus (HR-HPV) infection is a key factor in the progression of cervical lesions to cervical cancer. This study explores the molecular mechanisms through which the tradition...
Integrative single-cell transcriptomic and experimental analyses unveil Qihuang granule's protection against retinal photodamage via PI3K/AKT/mTOR-mediated autophagy [0.03%]
整合单细胞转录组和实验分析揭示七煌颗粒通过PI3K/AKT/mTOR介导的自噬保护视网膜光损伤
Zhao Zhang,Xiaoqian Shan,Fengming Liang et al.
Zhao Zhang et al.
Light-induced retinal damage is a significant contributor to age-related macular degeneration (AMD). Qihuang granule (QHG), a traditional Chinese herbal formulation, has been clinically employed in the treatment of retinal diseases, includi...
Proton activated chloride channel and its regulation of insulin secretion in β cells [0.03%]
质子激活的氯通道及其对β细胞胰岛素分泌的调节作用
Yi Wu,Fang Wang,Fang-Lin Peng
Yi Wu
Type II diabetes is a prevalent chronic disease worldwide, yet no curative treatment currently exists. Compromised insulin release is one of the hallmarks of type II diabetes, to restore insulin release is one standard to screen candidates ...
Paxillin mediates lung epithelial injury by activating NLRP3 inflammasomes in an acute respiratory distress syndrome mouse model [0.03%]
急呼吸窘迫综合征小鼠模型中，Paxillin通过激活NLRP3炎性小体介导肺上皮损伤
Honglin Feng,Xinyi Cao,Yong You et al.
Honglin Feng et al.
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a clinical syndrome characterized by diffuse lung inflammation and edema, with diffuse alveolar damage as the hallmark pathology. Paxillin plays a crucial role in the sig...
Linoleic acid promotes osteogenic differentiation of bone marrow mesenchymal stem cells and ameliorates ovariectomy (OVX)-induced osteoporosis in mice through the PI3K/AKT pathway [0.03%]
油酸通过PI3K/Akt途径促进骨髓间充质干细胞成骨分化并改善卵巢切除术(OVX)诱导的小鼠骨质疏松症
Hao Liao,Xiangping Luo,Liqin Jiang
Hao Liao
Bone mineral density (BMD) reduction is heavily involved in osteoporosis. Bone marrow mesenchymal stem cells (BMSCs) are promising candidates in the implantation treatment of bone loss-related diseases. Traditional Chinese herbs and their a...
Melatonin alleviates endoplasmic reticulum stress and its mediated inflammation in adipocytes via the PER1/ATF6 signal [0.03%]
褪黑素通过PER1/ATF6信号缓解内质网应激及其介导的脂肪细胞炎症反应
Li-Ping Dang,Rui Lv,Yun-Fei Zuo et al.
Li-Ping Dang et al.
Obesity is a major global health challenge closely associated with various metabolic diseases. A deeper understanding of the mechanisms underlying obesity, particularly the complex relationships between lipid metabolism, inflammation, and e...