A scalable stem cell-derived erythroid cell system for the encapsulation and delivery of therapeutic enzymes: An in vitro proof-of-concept study [0.03%]
一种可扩展的干细胞系源性红细胞系统用于治疗酶的封装和递送：一项概念验证的体外研究
Xiaobei Cheng,Biao Zhang,Yameng Ling et al.
Xiaobei Cheng et al.
Red blood cell (RBC)-based therapeutic enzyme delivery systems require cell sources that can support future standardized large-scale production, with the prerequisite that engineering modifications preserve the cells' inherent biocompatibil...
Type 2 diabetes mellitus limits the glucose-responsive β-like functionality but not pancreatic lineage commitment of induced human adipose-derived stem cells [0.03%]
2型糖尿病限制了诱导的人类脂肪源性干细胞的葡萄糖反应性β样功能但不影响其胰腺谱系决定命运
Nada A Mohamed,Amir M H Salem,Alaa Mohammed El-Erian et al.
Nada A Mohamed et al.
Background: Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases, whose prevalence is increasing worldwide. There is a great demand for an effective cure that attains a normal glucose level. The diff...
Tunneling nanotube-mediated intercellular spread of SARS-CoV-2 variants in epithelial cells reveals a host-targeted antiviral vulnerability [0.03%]
上皮细胞中的SARS-CoV-2变异株胞间传播揭示了针对宿主的抗病毒弱点
Gurleen Kaur,Ritika Khatri,Varun Kumar et al.
Gurleen Kaur et al.
We demonstrate that SARS-CoV-2 exploits tunneling nanotubes (TNTs) as actin-based conduits for intercellular transmission in epithelial cells. TNT formation was markedly enhanced in the Delta variant compared with the ancestral Wuhan-Hu-1 a...
Protein S-palmitoylation in osteoarticular cell signalling and metabolic adaptation [0.03%]
骨关节细胞信号传导和代谢适应中的蛋白质S-棕榈酰化作用
Xinqi Huang,Xinpeng Wei,Yun Tao et al.
Xinqi Huang et al.
Protein S-palmitoylation is a reversible lipid post-translational modification that dynamically controls protein localization, trafficking, receptor microdomain organization, autophagy and metabolic signalling. In osteoarticular tissues, th...
Qi Huang granules attenuate sodium iodate-induced retinal injury and inflammation via regulation of mitochondrial dynamics homeostasis [0.03%]
齐黄丸通过调节线粒体动力学稳态抑制碘酸钠诱导的视网膜损伤和炎症反应
Jifang Wang,Zhiqiang Wu,Lulu Fang et al.
Jifang Wang et al.
Qi Huang Granules (QHG), a traditional Chinese medicine (TCM) formulation, have been applied clinically for over two decades to treat dry age-related macular degeneration (AMD) and associated fundus lesions. Although its retinoprotective ef...
Recent advances in the role of mechanical signal transduction in hypertension [0.03%]
高血压领域机械信号转导的最新进展
Peili Yang,Yingqiang Zhao,Meijuan Lu et al.
Peili Yang et al.
Hypertension is a major risk factor for cardiovascular disease and alters the mechanical microenvironment of the vascular wall and target organs. Key mechanical disturbances include disturbed shear stress, excessive circumferential stretch,...
Corrigendum to "Differential activation of NF-kB signaling is associated with platinum and taxane resistance in MyD88 deficient epithelial ovarian cancer cells" [Int. J. Biochem. Cell Biol. 61 (2015) 90-102] [0.03%]
“NF-κB信号与铂和紫杉烷类耐药的相关性在MyD88缺陷卵巢癌细胞中被激活”的勘误页[国际生物化学与细胞生物学杂志。 2015，第61期（2015年）：90-102页]
Snehal M Gaikwad,Bhushan Thakur,Asmita Sakpal et al.
Snehal M Gaikwad et al.
CXCR4 targeting by TPCA‑1 attenuates neuroinflammation in intracerebral hemorrhage through inhibiting NF‑κB and AP‑1 activation [0.03%]
TPCA-1通过抑制NF-κB和AP-1的活化来减轻颅内出血后的神经炎症的作用及机制研究 CXCR4靶向治疗的新策略
Na Wang,Li Cao,Shi-Fang Bei et al.
Na Wang et al.
Intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI) is a critical contributor to poor neurological outcomes. In this study, we aimed to identify potential small‑molecule therapeutic agents and systematically validate their ...
Timosaponin A1 exerts antitumor effect against osteosarcoma by targeting JAK2/STAT3 signaling pathway [0.03%]
黄精皂苷A1通过靶向JAK2/STAT3信号途径发挥抗骨肉瘤作用
Jia Shi,Yixuan Xu,Tongtong Liu et al.
Jia Shi et al.
Novel therapeutic agents are urgently needed since osteosarcoma is a highly aggressive bone tumor primarily affecting children and adolescents that remains poorly responsive to conventional chemotherapy. Persistent aberrant activation of ST...
Circulating miRNA in metabolic syndrome and cancer: Machinery, diagnostics, and therapeutics [0.03%]
循环miRNA在代谢综合征和癌症中的作用：机制、诊断和治疗
Anh-Phi Phan,Rishi Kumar Jaiswal,Kim-Hung Huynh et al.
Anh-Phi Phan et al.
MicroRNAs (miRNAs) are key post-transcriptional regulators that play critical roles in cellular homeostasis and disease progression. Increasing evidence indicates their involvement in cancer-associated metabolic reprogramming, in which tumo...