Quorum sensing regulated neutrophil extracellular traps (NETs) dysregulation in chronic obstructive pulmonary disease (COPD): Host-pathogen interplay in Pseudomonas aeruginosa infection [0.03%]
铜绿假单胞菌感染中慢性阻塞性肺疾病患者条件致病菌与宿主 neutrophil extracellular traps 形成失调的相互作用机制研究
Honagodu Ravichandra Dhanyashree,Rajesh P Shastry
Honagodu Ravichandra Dhanyashree
Chronic Obstructive Pulmonary Disease (COPD) is not a single condition but a spectrum of diseases, which is characterised by airway limitation, mucus hypersecretion, and is further complicated by persistent bacterial infection leading to ex...
Serum-assisted metabolic priming enables robust structural maturation of hiPSC-cardiomyocytes in 2D and 3D systems [0.03%]
血清辅助代谢活化可促进二维和三维系统中hiPSC-CM的结构成熟
Xuan-Hung Nguyen,Manh Khanh Dinh,Minh-Anh Thi Dang et al.
Xuan-Hung Nguyen et al.
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are crucial for modeling cardiovascular disease and drug development, yet their immature phenotype remains a significant challenge. Cardiomyocyte maturation is an energy...
Mesenchymal Stem Cells and Their Exosomes from Umbilical Cord and Adipose Tissue in the Prevention of Postoperative Intra-abdominal Adhesions: A Rat Model Study [0.03%]
来自脐带和脂肪组织的间充质干细胞及其外泌体在预防术后腹腔内粘连中的作用：大鼠模型研究
Ali Akdemir,Arif Onur Atay,Levent Akman et al.
Ali Akdemir et al.
Objective: To compare anti-adhesive effects of umbilical cord- and adipose tissue-derived mesenchymal stem cells (MSCs) and their exosomes in a rat model of postoperative intra-abdominal adhesion, and to explore whether r...
Targeting programmed cell death pathways in diabetic foot ulcers: Mechanisms and therapeutic strategies [0.03%]
靶向糖尿病足溃疡的程序性细胞死亡途径：机制与治疗策略
Chuandong Liang,Pandeng Hao,Zheng Gong
Chuandong Liang
Diabetic foot ulcers (DFU) represent a severe chronic complication of diabetes with increasing global prevalence. Approximately 75% of lower limb amputations are attributable to diabetic foot disease, and the 5-year mortality rate following...
Ligustilide alleviates sepsis-associated acute kidney injury by activating Nrf2/HO-1 and PI3K/Akt signaling pathways [0.03%]
腹腔注射细柱鼠尾草乙素通过激活Nrf2/HO-1和PI3K/Akt信号通路缓解内毒素血症致急性肾损伤
Min Huang,Bo Xu,Hang Qi et al.
Min Huang et al.
Objective: Sepsis-associated acute kidney injury (AKI) is a life-threatening complication among hospitalized and critically ill patients, markedly by a swift decline in renal function. This study aimed to investigate the ...
"EPAC1: Molecular architecture, physiological regulation, and therapeutic implications in diseases" [0.03%]
"EPAC1：分子结构、生理调节及其在疾病治疗中的意义"
Adiba Mussarrat,Anjali Kumari,Manodeep Chakraborty et al.
Adiba Mussarrat et al.
Exchange Protein Directly Activated by cAMP 1 (EPAC1) is an intracellular effector of the small GTPases Rap1 and Rap2, functioning independently of protein kinase A in the cAMP signalling pathway. The structural analysis shows that EPAC1 ha...
Autophagy-mediated regulation of hepatic differentiation of human adipose tissue-derived mesenchymal stem cells [0.03%]
自噬介导的人体脂肪组织间充质干细胞向肝细胞分化的作用及机制研究
Reyhaneh Niayesh-Mehr,Abbas Piryaei,Ali Manafi et al.
Reyhaneh Niayesh-Mehr et al.
The regulation of mesenchymal stem cell (MSC) differentiation is a complex process influenced by multiple factors, among which autophagy has emerged as a key determinant of stem cell fate. Here, we investigated its role in MSC differentiati...
Beyond hemoglobin polymerization: Mitochondrial pathobiology and therapeutic frontiers in sickle cell disease [0.03%]
超越血红蛋白聚合并殖:镰状细胞病中的线粒体病理生理学和治疗前景
Rikesh K Dubey,Apoorva Narain
Rikesh K Dubey
Sickle cell disease (SCD) is a global health issue that affects millions of individuals and is caused by a mutation in the β-globin gene (HBB), leading to the formation of sickle-shaped erythrocytes. Traditionally, the primary focus in SCD...
Ferroptosis and cuproptosis in gastric cancer: Mechanisms, roles, and potential Interplay [0.03%]
胃癌中铁死亡和铜死亡的机制、作用及潜在相互作用
Jiawei Fu,Yijing Ren,Yuping Feng et al.
Jiawei Fu et al.
Gastric cancer (GC), a prevalent and lethal malignancy globally, remains a severe health concern because of its high incidence and fatality. Notably, ferroptosis and cuproptosis, both novel kinds of controlled cell death, were discovered to...
Downregulation of Pannexin-1 attenuates sepsis-induced acute lung injury via activation of the cAMP/PKA pathway [0.03%]
下调泛连接蛋白-1通过活化cAMP/PKA信号通路缓解内毒素致急性肺损伤作用及机制研究
Xiangming Liao,Hongmei Zhang
Xiangming Liao
Sepsis-induced acute lung injury (ALI) is a severe complication with limited treatment options. Pannexin-1 (PANX1), a membrane channel involved in inflammatory signaling, has been implicated in various diseases, but its role in ALI remains ...