Type I and III Interferons in Asthma and Respiratory Infections: New Insights for Potential Treatments [0.03%]
哮喘和呼吸道感染中的I型和III型干扰素：潜在治疗的最新见解
Zahra Jafari,Zahra Ahankoub Nazhdi,Melika EmamAlizadeh et al.
Zahra Jafari et al.
Asthma is a chronic lower respiratory system disease with high global prevalence and mortality rates. It is characterized by several clinical symptoms, including coughing, wheezing, dyspnea, and breathing difficulties. Despite extensive res...
Ipragliflozin Exerts Anti-Fibrotic Effects via a Novel Multi-Pathway Mechanism: Targeting TLR4/NF-κB /TGF-β1 Cascade [0.03%]
伊帕格列净通过新型多通路机制产生抗纤维化作用：靶向TLR4/NF-κB/TGF-β1级联通路
Mahdi H Alsugoor,Naif ALSuhaymi,Passant E Moustafa et al.
Mahdi H Alsugoor et al.
Hepatic fibrogenesis represents a significant and escalating global health challenge with few effective treatments. This research explored the anti-fibrotic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitor Ipragliflozin (IP...
Dysregulated epoxy fatty acid metabolism as a driver of pathophysiology: Biosynthesis, metabolism, and therapeutic implications [0.03%]
失调的环氧脂肪酸代谢在病理生理中的驱动作用：生物合成、代谢和治疗意义
G Akash,Vignesh Sakthivel,M Chandhru et al.
G Akash et al.
Epoxy fatty acids (EpFAs) are lipid mediators with dual physiological roles. They promote protective vascular and inflammatory responses when enzymatically balanced yet may drive pathological dysfunction when metabolic regulation is disrupt...
Unraveling the role of non-coding RNAs in Parkinson's disease: Molecular mechanisms and therapeutic insights [0.03%]
非编码RNA在帕金森病中的作用机制及治疗启示：解谜与洞见
Patrick Tang,Ziluo Jing,Zhengliang Tong et al.
Patrick Tang et al.
Parkinson disease (PD) is a progressive neurodegenerative disorder characterized by the selective loss of dopaminergic neurons in the substantia nigra pars compacta and pathological accumulation of α-synuclein in Lewy bodies. In this proce...
Dihydroorotate dehydrogenase: A multifunctional target in cancer, infectious diseases, and immune disorders [0.03%]
二氢乳清酸脱氢酶：癌症、传染病和免疫障碍疾病多种作用靶点
Xiaoying Guan,Jinchun Li,Xiaoli Guan et al.
Xiaoying Guan et al.
Pyrimidine is required for the biosynthesis of DNA, RNA, glycoproteins, and phospholipids. Dihydroorotate dehydrogenase (DHODH) is a crucial flavin-dependent enzyme in mitochondria involved in the de novo pyrimidine synthesis and has been c...
Time-resolved proteomics reveals five modules of stress granule disassembly and identifies SYNCRIP as a late-phase clearance factor [0.03%]
时间分辨蛋白质组学揭示了应激颗粒解离的五个模块，并鉴定出SYNCRIP为晚期清除因子
Suguru Fujita,Miyu Murata,Hyun-Woo Rhee et al.
Suguru Fujita et al.
Stress granules (SGs) are membraneless ribonucleoprotein condensates that form under stress and dissolve during recovery. While assembly mechanisms are well characterized, the temporal organization of disassembly remains incompletely unders...
Effectiveness and mechanism of different molecular weight hyaluronic acid in repairing intestinal barrier function [0.03%]
不同分子量透明质酸修复肠屏障功能的有效性及机制研究
Meng-Xin Sun,Dan Liu,Zi-Han Jiang et al.
Meng-Xin Sun et al.
Post-intensive care syndrome (PICS) presents significant clinical challenges due to impaired intestinal barrier function. This study investigated the molecular weight-dependent therapeutic efficacy of Hyaluronic Acid (HA) in a murine PICS m...
Targeting miR-133-3p via mesenchymal stem cells-derived exosomes as a novel cell-free therapy for testosterone-induced benign prostatic hyperplasia [0.03%]
靶向睾酮诱导的良性前列腺增生的新型细胞自由治疗：间充质干细胞衍生的外泌体抑制miR-133-3p
Ibrahim M Elazab,Nahla E El-Ashmawy,Ola A El-Feky et al.
Ibrahim M Elazab et al.
Benign prostatic hyperplasia (BPH), the leading cause of lower urinary tract symptoms (LUTS), is commonly treated with conventional therapies that often have undesirable side effects. Safer alternatives such as bone marrow mesenchymal stem ...
Single-cell transcriptomic analysis unveils dysregulated macrophage-podocyte crosstalk in membranous nephropathy [0.03%]
单细胞转录组分析揭示系膜性肾病中巨噬细胞-足细胞串话失调
Yinghui Zhang,Siyue Huang,Xueting Li et al.
Yinghui Zhang et al.
Background: Membranous nephropathy (MN) is an antibody-mediated glomerular disease, but the cellular networks driving injury remain poorly defined. Method...
Targeted degradation of Drosophila FOG homolog U-shaped mimics macrophage transdifferentiation in S2 cells [0.03%]
靶向降解果蝇FOG同源蛋白U-shaped模拟S2细胞中的巨噬细胞重编程
Deborah Trummel,Wiebke Milani,Jonathan Lenz et al.
Deborah Trummel et al.
The highly plastic cellular component of the Drosophila immune system consists of three main blood cell types - plasmatocytes, crystal cells and lamellocytes - that together allow effective responses to various insults. Infection with paras...