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Tunneling nanotube-mediated intercellular spread of SARS-CoV-2 variants in epithelial cells reveals a host-targeted antiviral vulnerability

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We demonstrate that SARS-CoV-2 exploits tunneling nanotubes (TNTs) as actin-based conduits for intercellular transmission in epithelial cells. TNT formation was markedly enhanced in the Delta variant compared with the ancestral Wuhan-Hu-1 and Omicron strains, ... ...