The influence of the route of drug administration on the metabolic profile of trenbolone in doping control urine samples [0.03%]
给药途径对尿样中 trenbolone代谢物分布的影响研究
Sophia Krombholz,Thomas Piper,Andreas Lagojda et al.
Sophia Krombholz et al.
Advances in analytical techniques have markedly improved the detection of anabolic-androgenic steroids (AAS) in doping controls. This represents a major success for anti-doping efforts, but at the same times raises concerns about inadverten...
Cortisol-to-cortisone and testosterone-to-androstenedione concentration ratios in nails: Their determination methods based on LC/MS/MS and differences from the serum concentration ratios in the literature [0.03%]
基于液质联用的指甲皮质酮-四氢皮质酮及睾丸素-雄烯二酮浓度比值检测及其与血清浓度比值的差异性分析
Himena Ishikawa,Sakurako Tanaka,Kenjiro Shibata et al.
Himena Ishikawa et al.
A fingernail clipping is expected to be a specimen suited for the detection of the medium-to-long term abnormal production of steroids. There are reports demonstrating that the concentration ratios of cortisol (F) to cortisone (E) and testo...
α-Silyl substituted vinyl carbanions in the synthesis of brassinolide and castasterone [0.03%]
全合成油菜素甾醇和castasterone中的α-亚烷基乙烯基碳负离子中间体
Maryia V Barysevich,Volha V Kazlova,Natalia M Chaschina et al.
Maryia V Barysevich et al.
A concise synthesis of brassinolide and castasterone has been accomplished herein. The strategy relies on the addition of α-silyl substituted vinyl carbanions to steroidal C-22 aldehydes with pre-formed functionalities in the cyclic part. ...
Microbial catalyzed derivatization of canrenone with Glomerella fusarioides, and Cunninghamella blakesleana, and evaluation of aromatase inhibitory activity of the resulting metabolites [0.03%]
丛赤壳菌和拟青毛霉催化卡伦酮的衍生化及所获衍生物的芳香酶抑制活性评价
Ambreen Aziz,Atia-Tul-Wahab,Ghulam Farooq et al.
Ambreen Aziz et al.
The purpose of this study was to identify potential aromatase inhibitors, which might play a role in preventing breast cancer. For this fungal-catalyzed microbial transformation of anti-mineralocorticoid, canrenone (1), was catalyzed by Glo...
Soy isoflavone Daidzein resembling the vertebrate steroid structure exhibits neuroprotection via mitochondrial biogenesis in rotenone induced Parkinson's disease in preclinical model [0.03%]
大豆异黄酮.daidzein.通过线粒体生物合成在罗毒素诱导的帕金森病临床前模型中表现出神经保护作用
Vaibhavi Peshattiwar,Suraj Muke,Aakruti Kaikini et al.
Vaibhavi Peshattiwar et al.
Parkinson's disease (PD) ranks as the second most prevalent neurodegenerative disorder but is still devoid of neuroprotective treatment. Although approaches with disease modifying ability along with symptomatic relief has become an utmost n...
Potential of betulinic acid in the Antiformation and eradication of bacterial biofilms and pharmacokinetic and toxicological analysis [0.03%]
白桦脂酸抗菌生物膜及根除潜能和药代动力学及毒性分析
Camila Aparecida Pereira da Silva,Nara Juliana Santos Araújo,Maria do Socorro Costa et al.
Camila Aparecida Pereira da Silva et al.
Bacterial biofilms are complex, organized structures that adhere to surfaces, protected by a self-produced extracellular matrix. This conformation makes it difficult to eradicate infections with conventional treatments. In view of this, nat...
Exploring the relationship between endogenous steroids and nausea and vomiting in pregnancy: A longitudinal prospective study [0.03%]
妊娠期间内源性类固醇与恶心呕吐关系的前瞻性研究
Jana Benešová,Martin Hill,Daniela Dlouhá et al.
Jana Benešová et al.
Nausea and vomiting in pregnancy (NVP) affect approximately 70 % of women worldwide. It is thought to have an adaptive function in the first trimester, when it protects the mother and the fetus against potential dangers from the diet. Proxi...
Nutrient manipulation regulates growth and steroidal alkaloid production in plant cultures of Solanum viarum Dunal [0.03%]
营养调控对Solanum viarumDunal植物培养生长及甾类生物碱积累的影响
Archana Prasad,Preeti Patel,Abhishek Niranjan et al.
Archana Prasad et al.
Solanum viarum is a valuable medicinal plant native to India and widely distributed throughout Asia. It serves as a commercially viable raw source for the steroidal drug industry, being the richest natural source of an important steroidal a...
Beta-Ecdysone protects osteocytes from excess glucocorticoids via Akt1-mediated regulation of Connexin43 [0.03%]
β-ecdysone通过Akt1介导的Connexin43调节保护骨细胞免受糖皮质激素过多损伤
Anna Xie,Libo Wang,Yu Zhang et al.
Anna Xie et al.
Glucocorticoid-induced osteoporosis (GIOP) is a leading cause of secondary osteoporosis (OP). β-Ecdysone (βEcd), a naturally occurring estrogen analog, was evaluated for its ability to mitigate the effects of glucocorticoids (GCs) on oste...
Kobochromone A, a polyphenol in Carex kobomugi, suppresses androgen signaling induced by 11-oxygenated androgens and enhances the efficacy of AKT inhibitors in triple-negative breast cancer cells [0.03%]
尖叶苔草中的聚酚类化合物Kobochromone A可通过抑制11-氧雄激素诱导的雄激素信号通路增强AKT抑制剂在三阴性乳腺癌细胞中的疗效
Masatoshi Tanio,Yuri Miyamoto,Tomofumi Saka et al.
Masatoshi Tanio et al.
Breast cancer is the most common cancer in women, with triple-negative breast cancer (TNBC) accounting for approximately 20% of cases. TNBC lacks estrogen receptors (ER), progesterone receptors (PR), and epidermal growth factor receptor 2 (...