Donepezil enhances the testicular protective effect of metformin in diabetic rats by modulating steroidogenic signaling and Bax/Bcl-2/Caspase-3 pathway [0.03%]
多奈哌齐通过调节类固醇生成信号和Bax/Bcl-2/Caspase-3通路增强二甲双胍在糖尿病大鼠睾丸保护中的作用
Roland Eghoghosoa Akhigbe,Joseph Chimezie,Ajibola Ayomide Odeyemi et al.
Roland Eghoghosoa Akhigbe et al.
Background: Type 2 diabetes mellitus (T2DM) induces testicular damage through xanthine oxidase (XO)/uric acid (UA)/caspase-3-driven oxidative stress and apoptosis. Although metformin is effective in managing diabetes, com...
The protective effects of luteolin and oleuropein against dexamethasone-induced hyperlipidemia [0.03%]
黄茋配剂中主要成分异黄酮和橄榄素对糖皮质激素所致高脂血症的保护作用研究
Lourin Nasr Aziz,Mohamed Omar Mahmoud,Ibrahim Taha Ibrahim
Lourin Nasr Aziz
Background: Dexamethasone-induced hyperlipidemia is a well-documented metabolic complication associated with prolonged glucocorticoid therapy. The present study aims to investigate the potential protective effects of the ...
Identification of multiple cardiotonic steroids in faecal material of untreated humans and rat strains [0.03%]
人和大鼠粪便中多种糖皮质激素的鉴定
Zelie F Masso,Hannah Bint Ebrahim Mullah,Anza Thiba et al.
Zelie F Masso et al.
Endogenous cardiotonic steroid (CTS) concentrations are raised in cardiovascular diseases. CTSs undergo gastro-hepatobiliary recirculation, with the gut being an important route of elimination, yet the presence of CTSs in faecal material is...
l-arginine mitigates endocrine and spermatogenesis disruptions in cisplatin-exposed male Wistar rats by modulating iNOS/NO/NF-kB and Nrf2/HO-1 signaling [0.03%]
L-精氨酸通过调节iNOS/NO/NF-κB和Nrf2/HO-1信号通路缓解顺铂暴露的成年大鼠的内分泌干扰及生精障碍
O O Obembe,G A Oyeniyi,P J Ashonibare et al.
O O Obembe et al.
Background: Even though cisplatin is highly effective, its toxicity to non-target organs, such as testicular toxicity, remains a concern. Studies have shown that cisplatin induces testicular toxicity by activating an oxid...
Novel heterosteroids induce anabolic effects in human skeletal muscle cells: An integrated analysis of anabolic and catabolic signaling pathways [0.03%]
新型杂甾体诱导人体骨骼肌细胞的同化效应：整合分析同化和异化信号通路
Linda Fabiola Pérez-Pérez,Gabriel Guerrero-Luna,Adrián Mendoza-Montalvo et al.
Linda Fabiola Pérez-Pérez et al.
The aim of this study was to investigate the anabolic potential of novel heterosteroids in human skeletal muscle cells. A library of new heterosteroids was synthesized by selectively modifying the A and B rings of steroidal sapogenins (dios...
The effects of tamoxifen and its metabolites on circulating estrogen metabolites among pre- and postmenopausal women [0.03%]
他莫昔芬及其代谢产物对绝经前和绝经后妇女血液循环雌激素代谢产物的影响
Rajrupa Ghosh,Ruth M Pfeiffer,Cody Ramin et al.
Rajrupa Ghosh et al.
Purpose: Circulating estrogen metabolites of the 2-, 4- or 16-hydroxyestrone (OH) pathways may be differentially associated with breast cancer risk due to varying estrogenic and genotoxic activity. However, little is know...
Endoplasmic reticulum stress and steroidogenic dysfunction in Leydig cells: Molecular mechanisms of UPR-mediated testosterone regulation [0.03%]
内质网应激和类固醇生成障碍在曲细精管细胞中：UPR介导的睾酮调节的分子机制
Luc J Martin
Luc J Martin
This review aims to synthesize current evidence on how endoplasmic reticulum (ER) stress affects steroidogenic function in Leydig cells. It explores the mechanisms by which ER stress activates the unfolded protein response (UPR) and autopha...
The impact of reproductive steroids on autosomal dominant polycystic kidney disease progression in women [0.03%]
生殖激素对常染色体显性多囊肾病女性患者的影响
Noor Saeed Hasan,Warren Thomas
Noor Saeed Hasan
Autosomal dominant polycystic kidney disease (ADPKD) is a disease characterized by the growth of fluid filled cysts in the kidney. ADPKD arises due to a heritable mutation in the polycystic kidney disease 1 gene (PKD1) and polycystic kidney...
An unexpected oxidative E/F ring opening in the side chain of steroid sapogenins produced by silica gel supported jones reagent [0.03%]
固相支撑的琼斯试剂诱导甾体皂苷元侧链氧化 Unexpected的E/F环断裂反应研究
Juan E Hernández-Martínez,Karen M Ruíz-Pérez,Jacqueline Sanchez-Flores et al.
Juan E Hernández-Martínez et al.
In contrast with previous results in which the spiroketal side chain of steroid sapogenin has proven to be unreactive to Jones reagent, treatment these sapogenins with silica gel-supported Jones reagent triggered the oxidative opening of th...
LC-MS/MS quantitation of the primary reduced metabolites of progesterone in serum during the third trimester of human pregnancy reveals a potential role for 20β-hydroxyprogesterone and 5β-dihydroprogesterone in functional progesterone withdrawal [0.03%]
液相色谱-串联质谱法测定人妊娠第三孕期血清中孕酮主要还原代谢产物的含量，提示20β-羟基黄体酮和5β-双氢孕酮在孕酮功能撤退中的潜在作用
Edward Hinchliffe,Alexander Heazell
Edward Hinchliffe
Progesterone (P4) is an essential steroid hormone synthesised by the placenta required for the maintenance of pregnancy. In humans, the metabolism of P4 has been implicated in functional P4 withdrawal prior to parturition. We have developed...