The impact of reproductive steroids on autosomal dominant polycystic kidney disease progression in women [0.03%]
生殖激素对常染色体显性多囊肾病女性患者的影响
Noor Saeed Hasan,Warren Thomas
Noor Saeed Hasan
Autosomal dominant polycystic kidney disease (ADPKD) is a disease characterized by the growth of fluid filled cysts in the kidney. ADPKD arises due to a heritable mutation in the polycystic kidney disease 1 gene (PKD1) and polycystic kidney...
An unexpected oxidative E/F ring opening in the side chain of steroid sapogenins produced by silica gel supported jones reagent [0.03%]
固相支撑的琼斯试剂诱导甾体皂苷元侧链氧化 Unexpected的E/F环断裂反应研究
Juan E Hernández-Martínez,Karen M Ruíz-Pérez,Jacqueline Sanchez-Flores et al.
Juan E Hernández-Martínez et al.
In contrast with previous results in which the spiroketal side chain of steroid sapogenin has proven to be unreactive to Jones reagent, treatment these sapogenins with silica gel-supported Jones reagent triggered the oxidative opening of th...
LC-MS/MS quantitation of the primary reduced metabolites of progesterone in serum during the third trimester of human pregnancy reveals a potential role for 20β-hydroxyprogesterone and 5β-dihydroprogesterone in functional progesterone withdrawal [0.03%]
液相色谱-串联质谱法测定人妊娠第三孕期血清中孕酮主要还原代谢产物的含量，提示20β-羟基黄体酮和5β-双氢孕酮在孕酮功能撤退中的潜在作用
Edward Hinchliffe,Alexander Heazell
Edward Hinchliffe
Progesterone (P4) is an essential steroid hormone synthesised by the placenta required for the maintenance of pregnancy. In humans, the metabolism of P4 has been implicated in functional P4 withdrawal prior to parturition. We have developed...
Semi-synthetic sapogenin derivatives inhibit inflammation-induced tumorigenic signaling alterations in prostate carcinogenesis [0.03%]
半合成皂苷衍生物可抑制前列腺癌发生过程中炎症诱导的肿瘤生成信号改变
Bilge Debelec-Butuner,Mert Burak Ozturk,Ozgur Tag et al.
Bilge Debelec-Butuner et al.
Prostatic inflammation plays a pivotal role in prostate cancer development and progression via altering key cellular mechanisms, including proliferation, metastasis, and angiogenesis. Therefore, the use of anti-inflammatory drugs could prov...
Antifungal ergostane-type steroids from endophytic fungus Xylaria sp. VDL4 [0.03%]
来源于内生菌Xylaria sp. VDL4的抗真菌 Ergostane型固醇类化合物
Jiao Yao,Lin-Hong Lu,Sheng-Yun Wei et al.
Jiao Yao et al.
Three ergostane-type steroids, including one rare C-29 methylated xylarstane A (1) and one C22,23-epoxied xylarstane B (2), along with one reported compound 3, were isolated from the endophytic fungus Xylaria sp. VDL4 harbored within the me...
Exposure-response of serum biomarkers to vamorolone, a dissociative corticosteroidal anti-inflammatory drug, in 4- to [0.03%]
分离型皮质类固醇抗炎药vamorolone的血清生物标志物暴露-反应关系（4至
Swati Mummidivarpu,Utkarsh J Dang,Michael Ziemba et al.
Swati Mummidivarpu et al.
Objectives: Corticosteroid agonists of the glucocorticoid receptor are a mainstay of therapeutics for pro-inflammatory conditions. Vamorolone is a novel partial agonist that is differentiated from the other members of the...
Discovery of dihydrobetulinic acid as a potent small molecule CD73 inhibitor [0.03%]
白桦脂酸发现成强大的小分子CD73抑制剂
Hongling Wang,Yanming Zhang,Chunyang Lou et al.
Hongling Wang et al.
Betulinic acid (BA) is a pentacyclic triterpene compound with various biological activities. Herein, we designed and synthesized a series of dihydrobetulinic acid (DHBA) and its derivatives for the discovery of potent ecto-5'-nucleotidase (...
In vitro metabolic profiling of 6-chloro-testosterone and 6-ene-testosterone by liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-time of flight (GC-TOF) mass spectrometry [0.03%]
液相色谱-质谱及气相色谱飞行时间质谱分析6-氯睾酮和6-亚甲基睾酮的体外代谢产物
Dayamin Martínez Brito,Carlotta Stacchini,Cristiana Colamonici et al.
Dayamin Martínez Brito et al.
Among the phase-I reactions of 6-chloro-testosterone (6-CT), the reductive and oxidative dehalogenation, as well as the dehydrogenation, have been described here. One of the metabolic products could be the 6-ene-testosterone (6-ene-T). The ...
Protective effect of vitamin D on high-fat-diet-induced metabolic dysfunction-associated steatotic liver disease in mice [0.03%]
维生素D通过调节肠道菌群对高脂饮食诱导的代谢紊乱相关脂肪性肝病小鼠模型的保护作用研究
Amal A Mohamed,Wael Hafez,Saied Faky et al.
Amal A Mohamed et al.
Background: Genetics, inflammation, and nutrition contribute to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). Aim:...
Dehydroepiandrosterone impact on smooth muscle contractile activity by a nongenomic action [0.03%]
脱氢表雄酮通过非基因组作用影响平滑肌收缩活性
Mercedes Perusquía
Mercedes Perusquía
Dehydroepiandrosterone (DHEA) is the most abundant steroid hormone in primates; however, its levels decline with age in both men and women. Numerous studies have documented diverse biological activities of DHEA. This article reviews the cur...