Efficient synthesis of 15α-hydroxysteroid derivatives by Fusarium redolens [0.03%]
赭红曲霉高效合成15α-羟基类固醇衍生物
Tong Sun,Yu Wang,Xi Chen et al.
Tong Sun et al.
Microbial hydroxylation of steroids at specific positions offers a sustainable and selective strategy for the synthesis of pharmacologically valuable derivatives. Through microorganism screening, the strain Fusarium redolens exhibited the h...
Synthesis and biological evaluation of new ergosterol pyridine derivatives as potential anticancer agents [0.03%]
一类新的麦角固醇并吡啶衍生物的合成及其体外抗肿瘤活性研究
Jian-Jia Liang,Xian-Fei Chen,Xiu-Ji Liu et al.
Jian-Jia Liang et al.
A series of novel ergosterol pyridine derivatives were synthesized via a three-component reaction and their antiproliferative activity was preliminarily evaluated against two human cancer cell lines. Structure-activity relationship (SAR) st...
Exploration of steroidal alkaloids: Integrating pharmacognosy, chemoinformatics and artificial intelligence for application diversification [0.03%]
甾体生物碱的探索研究：融合生药学、化学信息学及人工智能实现药物应用多样化
Swati Patil,Mandar Mulik,Chetana Eknure et al.
Swati Patil et al.
Steroidal alkaloids are a structurally diverse class of nitrogen-containing natural products with strong pharmacological potential, including anticancer, anti-inflammatory, and neuroprotective activities. Despite their therapeutic potential...
Synthesis of steroids fused with a pyridine at C11-C12 to accommodate the active site ceiling of cytochrome P450 8B1 [0.03%]
在C11-C12位置与吡啶环融合的固醇类化合物的合成及其与细胞色素P450 8B1活性中心顶板的对接研究
Tu M Ho,Elyse K Frydendall,Jiaying Zhou et al.
Tu M Ho et al.
The inhibition of cytochrome P450 8B1 (CYP8B1), the oxysterol 12α-hydroxylase enzyme, is a therapeutic strategy to treat obesity, non-alcoholic fatty liver disease, and diabetes. While nitrogenous heterocycles coordinating the heme are com...
Concise synthesis of 7-dehydrocholesterol and 25-hydroxy-7-dehydrocholesterol [0.03%]
7-脱氢胆固醇和25-羟基金属醇的简洁合成法
Yan-Xin Yue,De-Jie Zhang,Jia-Jie Xu et al.
Yan-Xin Yue et al.
7-Dehydrocholesterol (7-DHC) and its hydroxylated product, 25-hydroxy-7-dehydrocholesterol (25-OH-7-DHC), exhibit diverse biological activities and serve as key precursors in the industrial synthesis of vitamin D3 (VD3) and 25-hydroxyvitami...
Conessine, a steroidal alkaloid from Holarrhena antidysenterica: Ethnomedical roots, pharmacological insights, and formulation strategies for modern drug development [0.03%]
来自防痢马钱的甾类生物碱康赛辛：民族医药根基，药理学见解及现代药物开发策略
Ghaida Mustafa,Shaza Ibrahim Musa,Priyanka Shinde et al.
Ghaida Mustafa et al.
Holarrhena antidysenterica preparations have been used traditionally since ancient times for the treatment of gastrointestinal disorders, parasitic infections, and inflammatory conditions. Conessine is the main steroidal alkaloid of Holarrh...
Testosterone-TGF-β crosstalk modulates cell migration in human glioblastoma-derived cell lines [0.03%]
睾酮-TGF-β信号交叉对话可调节人胶质母细胞瘤系的细胞迁移
Omar Rafael Alemán,Juan Carlos Quintero,Laura Noemi Hernández-Lúa et al.
Omar Rafael Alemán et al.
Glioblastoma (GB) is the most aggressive brain tumor due to its extensive cellular migration. Although testosterone (T) and transforming growth factor-β (TGF-β) can regulate GB cell migration, the interaction between them in migration reg...
Evaluation of serum Afamin and oxidative stress biomarkers in polycystic ovarian syndrome overweight women [0.03%]
评估Afamin及氧化应激生物标志物在多囊卵巢综合征肥胖女性中的表达水平
Sara Sardar Hamad,Sardar Nouri Ahmed
Sara Sardar Hamad
Afamin is a human vitamin E-binding glycoprotein that plays an essential role in protection against oxidative damage and disease. This study was conducted at Shahid Doctor Khalid Hospital in the Koya-Erbil Governorate. A total of 120 women,...
Raman spectroscopy-based metabolic fingerprinting of seminal plasma reveals distinct profiles among fertile men [0.03%]
基于拉曼光谱的代谢指纹技术揭示了健康生育男性精浆间的不同特征
Kambiz Gilany,Naser Jafarzadeh,Elham Hosseini et al.
Kambiz Gilany et al.
Traditional semen analysis provides valuable insights into male fertility but fails to capture the full biochemical complexity underlying sperm function. This study explored metabolic variability among fertile men using Raman spectroscopy t...
Veratrum-derived steroidal alkaloids: from scaffold to pharmacological leads [0.03%]
VERATRUM来源的生物碱：从天然产物到药物先导化合物
Burçin Özüpek,Sultan Pekacar,Ömer Furkan Güverti et al.
Burçin Özüpek et al.
Veratrum species (Melanthiaceae) have a long history of medical usage throughout Europe, Asia, and North America. However, they are well-known for their toxicity. Their pharmacological significance stems from a number of steroidal alkaloids...