Shifting global drug discovery landscape and the critical role of startups in strengthening national capabilities [0.03%]
shifting global drug discovery landscape and the critical role of startups in strengthening national capabilities
Ryo Okuyama
Ryo Okuyama
This study examines the relationship between startup growth and national drug discovery capability. Analysis of the countries of origin of compounds in US Phase 3 trials compared to those of FDA-approved drugs revealed growth in Asia, parti...
Computational approaches enhance the design of molecular glue degraders for undruggable proteins [0.03%]
计算方法增强分子胶降解剂的设计以应对难以成药的蛋白质问题
Sirishantha G M A Deshani,Gunarathna R D S Madushani,Karunaratne Veranja et al.
Sirishantha G M A Deshani et al.
Most proteins remain 'undruggable' by traditional approaches, which are unable to engage targets because of a lack of well-defined binding pockets, causing a bottleneck in drug discovery. Molecular glue degraders (MGDs) have emerged as a pr...
The role of seaweed-derived natural components in obesity: A systematic review [0.03%]
海藻衍生天然成分在肥胖作用中的系统性综述
Jiao Tan,K K Asanka Sanjeewa,Ginnae Ahn et al.
Jiao Tan et al.
Obesity results from an imbalance between energy intake and expenditure, with over-processed foods and sedentary lifestyles being key contributors to the growing global obesity epidemic. This condition has numerous complications like hypert...
Target product profile: An essential tool to deliver differentiated, patient-centered, and reimbursable medical products to treat substance use disorders [0.03%]
目标产品档案：递送差异化、以患者为中心且可报销的医疗产品的关键工具，用于治疗物质使用障碍
Tam Nguyen,Elena Koustova
Tam Nguyen
Target product profiles (TPPs) guide medical product development by defining desired characteristics to address specific diseases or needs. By specifying safety, efficacy, usability, access, and differentiation, TPPs help to prioritize reso...
Gui Yao,Leming Shi,Yuanting Zheng
Gui Yao
The global oncology drug pipeline is characterized by a tension between the diversification of novel targets and a persistent concentration on a few validated ones. Our analysis of 5127 drugs against 1603 targets categorizes entities as 'pr...
Linear triazenes: Versatile scaffolds for chemical biology and drug design [0.03%]
线性三氮烯：化学生物学和药物设计中的多功能支架
Ahammed Ameen Thottasseri,Anju Agnes Tom,Deepthi Ramesh et al.
Ahammed Ameen Thottasseri et al.
Analyzing the advances in and emergence of novel triazenes is pivotal in medicinal chemistry. Triazenes exhibit biological activity through alkylation, redox processes, or interactions with biomolecules, producing synergistic effects enabli...
Charles H Jones
Charles H Jones
Yenisetti Rajendra Prasad,Sandeep,Prakash Y Khandave et al.
Yenisetti Rajendra Prasad et al.
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections and hospitalizations among vulnerable populations, such as children, older adults, and individuals with weakened immune systems, often causing season...
Use of new approach methodologies (NAMs) in epilepsy research and seizure risk assessment [0.03%]
新方法在癫痫研究和发作风险评估中的应用
Ruth A Roberts,Mamta Behl,Helena T Hogberg et al.
Ruth A Roberts et al.
Seizures are the hallmark of treatment-resistant epilepsy and are also a frequent adverse event in drug safety testing. Here we present a critical evaluation of new approach methodologies (NAMs) in epilepsy research and seizure liability. S...
Biotechnology-based therapies for mitigation of pulmonary fibrosis: an update [0.03%]
基于生物技术的肺纤维化缓解疗法最新研究进展
Satvik Sangai,Dhrumi Patel,Sarika Wairkar
Satvik Sangai
Pulmonary fibrosis (PF) is a chronic interstitial lung disease that causes inflammation and scarring around the lung alveoli. This scarring is called fibrosis and leads to breathing difficulties in patients. The treatment for PF is currentl...