Serum PD-L1 and CTLA-4 levels as biomarkers of acute rejection and renal dysfunction in kidney transplant recipients [0.03%]
肾移植受者中血清PD-L1和CTLA-4水平作为急性排异反应和肾功能损害的生物标记物研究
Angelica Canossi,Fabio Vistoli,Pierluigi Sebastiani et al.
Angelica Canossi et al.
Purpose: Acute rejection in kidney transplantation is a critical barrier to long-term graft survival and the PD-1/PD-L1 and CTLA-4 molecules are crucial for the tolerance of alloreactive T cells against tubular epithelial...
Identification of allogeneic and xenogeneic neural stem cells' immunogenicity in the brain and strategies to alleviate transplantation rejection [0.03%]
鉴定脑内同种和异种神经干细胞的免疫原性及缓解移植排斥的策略
Xiangyu Ma,Ho Jin Lee,Dong Oh Kim et al.
Xiangyu Ma et al.
Neural stem cells (NSCs) are a promising therapy for central nervous system (CNS) disorders, yet post-transplant immune rejection critically compromises their survival and efficacy. In this study, we demonstrated the neuroinflammatory respo...
Immunosuppression minimization and withdrawal in liver transplantation: The "holy grail"? [0.03%]
肝移植中的免疫抑制减量和撤药——“圣杯”吗？
V U Lakshmi,Mohammed Riyas,Dinesh Balakrishnan et al.
V U Lakshmi et al.
Liver transplantation typically necessitates the use of life long immunosuppressive drugs, to suppress the immune system and minimize the risk of rejection. Prolonged use of immunosuppressive drugs can, however, lead to various side effects...
Early post-lung transplant cell-free DNA levels are associated with baseline lung allograft function [0.03%]
移植后早期细胞游离DNA水平与基线肺移植物功能有关
Zajacova Andrea,Alkhouri Majd,Ferrao Goncalo et al.
Zajacova Andrea et al.
Background: Baseline lung allograft dysfunction (BLAD) is defined as the failure to achieve normal pulmonary function-specifically, forced expiratory volume in 1 s (FEV₁) and forced vital capacity (FVC) values of ≥80 %-...
Recombinant human thrombopoietin reduces the risk of acute graft-versus-host-disease and its mechanism [0.03%]
重组人血小板生成素可降低急性移植物抗宿主病风险及其机制研究
Hairong Fei,Xiaodan Liu,Xiaolin Ma et al.
Hairong Fei et al.
Objective: Acute graft-versus-host disease (aGVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study aimed to evaluate the effect of recombinant human thrombopoietin (...
Rapamycin-modified CD169low/-tolDC promotes skin graft survival in mice via IL-10+Breg [0.03%]
雷帕霉素修饰的CD169低表达/阴性tolDC通过IL-10+Breg促进小鼠皮肤移植存活
Xi Lu,Yu-di Han,Xiao-Ran Zu et al.
Xi Lu et al.
Skin allografts are prone to rejection because of their high immunogenicity. By achieving immune tolerance, the long-term survival of skin allografts can be extended without the need for immunosuppressants or with only short-term low-dose d...
Successful use of cemiplimab in a high immunologic risk kidney transplant recipient with metastatic squamous cell carcinoma [0.03%]
塞米利玛布成功用于一名高免疫风险的移植物受者并发转移性鳞状细胞癌患者的治疗
Elena-Bianca Barbir,Abdullah Jalal,Joseph Grande et al.
Elena-Bianca Barbir et al.
The widespread use of immunotherapy in the management of cancers has led to improved overall survival and progression free survival. Due to increased risk of allograft rejection, organ transplant recipients are often excluded in clinical tr...
Survey of prevalence of BKV and JCV infections in pediatric heart transplant recipients [0.03%]
儿童心脏移植受者中BKV和JCV感染流行率的调查研究
Fatemeh Gabeleh,Mohammad Mahdavi,Mohammad Hadi Karbalaie Niya et al.
Fatemeh Gabeleh et al.
Background: The Administration of anti-rejection medications in solid organ recipients may increase the risk of acquiring multiple infections. This study aimed to diagnose and monitor BKV and JCV viral infections in pedia...
Successful treatment of very severe aplastic anemia with double unrelated umbilical cord blood transplantation in a donor-specific antigen positive adult patient: A case report and review [0.03%]
人脐血移植治疗严重难治性再生障碍性贫血1例及文献复习
Meng Lu,Jia-Yan Leng,Chen-Yun Xu et al.
Meng Lu et al.
To overcome the cell-dose barrier of cord blood, double unrelated umbilical cord blood transplantation (UCBT) has become increasingly common in adults with severe aplastic anemia (SAA). Pre-existing donor-specific anti-HLA antibodies (DSAs)...
Plasma-circulating miR-638, miR-6511b-5p, miR-3613-5p, miR-455-3p, miR-5787, and miR-548a-3p as noninvasive biomarkers of immune reconstitution post-allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients [0.03%]
allo-HSCT后急性髓系白血病患者免疫重建的无创标志物：miR-638、miR-6511b-5p、miR-3613-5p、miR-455-3p、miR-5787和miR-548a-3p
Marzieh Izadifard,Mohammad Ahmadvand,Bahram Chahardouli et al.
Marzieh Izadifard et al.
Introduction: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a viable treatment option for acute myeloid leukemia (AML), though it carries risks including delayed immune reconstitution and hematopoietic...