Accurate prediction of cytomegalovirus disease through optimized viral load cut-offs in intermediate-risk kidney transplant recipients [0.03%]
通过优化病毒载量临界值准确预测中危肾移植受者的巨细胞病毒感染病症
Tauana Freitas Casagrande,Heloisa Cristina Caldas,Pedro Henrique Fogaça Jordão et al.
Tauana Freitas Casagrande et al.
Background: Cytomegalovirus (CMV) infection remains a major complication in kidney transplant recipients (KTRs), particularly among donor-negative/recipient-positive (D-/R+) individuals, who are at intermediate risk for v...
CD34+/CD3+ cells ratio in the peripheral blood stem cells product and graft-versus-host disease: Is there still room for improvement? [0.03%]
外周血干细胞制品中CD34+/CD3+细胞比值与移植物抗宿主病的关系：还有没有提升的空间？
Ewa Bembnista,Paula Matuszak,Anna Łojko-Dankowska et al.
Ewa Bembnista et al.
Allogeneic hematopoietic stem cell (allo-HSC) transplantation (allo-HSCT) is a therapy of choice for patients requiring total bone marrow replacement. One of the critical issues is optimizing the number of allo-HSCs for successful outcomes,...
Recovery of CMV immunity after allogeneic haematopoietic stem cell transplant - Insight from an in-depth analysis of a small cohort of patients with clinical correlation [0.03%]
同种异体造血干细胞移植后CMV免疫的恢复——一项包含临床相关性的患者小样本的深入分析所获得的启示
Yeh-Ching Linn,Kirubavathy Sundar Raj
Yeh-Ching Linn
Background: We conducted an evaluation of the IFN-g ELISpot assay with the primary objective of exploring its clinical use after allogeneic haematopoietic stem cell transplant (allo-HSCT). Here we analysed its correlation...
Inhibition of USAG-1 improved delayed graft function in renal transplantation [0.03%]
USAG-1抑制改善了肾移植的延迟移植物功能
Yongsheng Luo,Hongxuan Ma,Jiajia Sun et al.
Yongsheng Luo et al.
Delayed graft function (DGF) is a critical complication following kidney transplantation. This study aimed to identify novel biomarkers and therapeutic targets for DGF. Transcriptomic data from the Gene Expression Omnibus (GEO) database wer...
TLR3 stimulation rejuvenates aged mesenchymal stem cells and restores immunosuppressive function in graft-versus-host disease [0.03%]
TLR3刺激可使衰老的间充质干细胞恢复年轻并能在移植物抗宿主病中恢复免疫抑制功能
Linlin Jin,Ziqi Hu,Yuxin Huang et al.
Linlin Jin et al.
Graft-versus-host disease (GVHD) remains a major complication of allogeneic hematopoietic stem cell transplantation, particularly in patients who are refractory to corticosteroids. Mesenchymal stem cells (MSCs) possess immunosuppressive pro...
Impact of everolimus-based immunosuppression on transplant rejection or death in lung transplant recipients using the United States Food and Drug Administration adverse event reporting system [0.03%]
一项基于美国食品药品管理局不良事件报告系统评估依维莫司免疫抑制在肺移植受者中排斥反应或死亡影响的研究
Toru Ogura,Chihiro Shiraishi,Aiko Urawa
Toru Ogura
Background: The off-label use of everolimus in lung transplant recipients (LTRs) has increased; however, its safety profile across different immunosuppressive regimens remains insufficiently characterized. This study expl...
Rituximab-based antibody mediated rejection therapy modestly reduces Xenoreactive antibodies: Implications for pig-to-human xenotransplantation [0.03%]
利妥昔单抗为基础的抗体介导排斥反应治疗可适度降低异种抗体：对猪-人异种移植的启示
Szu-Tsen Yeh,Nicole A Marshall,Brent P Lehman et al.
Szu-Tsen Yeh et al.
Background: Anti-pig antibodies, including those targeting porcine glycans and swine leukocyte antigens, present a significant challenge to pig-to-human xenotransplantation. Current strategies for managing these antibodie...
Clinical characteristics, risk factors, and treatment outcomes of tuberculosis in recipients of solid organ or hematopoietic stem cell transplantation [0.03%]
器官移植和造血干细胞移植受者结核病的临床特征、危险因素及治疗结局
Fuyan Shu,Ping Yuan,Guohui Zhu et al.
Fuyan Shu et al.
Background: Tuberculosis (TB) is one of the most severe complications following organ and tissue transplantation. Early detection and prompt initiation of anti-TB therapy are therefore essential to reduce mortality among ...
Impact of induction agent selection on rejection, allograft function, and survival in kidney transplant recipients [0.03%]
诱导药物选择对肾移植受者的排斥反应、移植物功能和生存的影响
Mohamad Saria Aldarwish,Wassim Toomah,Amro Idilbi et al.
Mohamad Saria Aldarwish et al.
Background: Kidney allograft rejection, driven by the recipient's immune response to non-self-HLA, remains a key barrier to kidney allograft survival. Induction therapy seeks to suppress early alloimmunity and reduce reje...
mRNA vaccine for human cytomegalovirus in immunocompromised hosts: An immunoinformatics approach [0.03%]
免疫受损宿主的人巨细胞病毒mRNA疫苗的免疫信息学方法研究
Muhammad Zeeshan Ahmed,Sana Dilbar,Syeda Masooma Zahra Bukhari et al.
Muhammad Zeeshan Ahmed et al.
Human cytomegalovirus (HCMV) poses a significant threat to immunocompromised individuals, including transplant recipients, neonates, and patients with immunosuppression. Despite extensive research, no effective vaccine exists-especially one...