Standardized bovine colostrum derivative impedes development of type 1 diabetes in rodents [0.03%]
标准化的牛初乳制剂可阻碍啮齿动物1型糖尿病的发展
Ivana Nikolic,Ivana Stojanovic,Milica Vujicic et al.
Ivana Nikolic et al.
Bovine colostrum is a rich source of nutrients and immunologically active components that play a role in conveying passive immunity to the offspring, protection and maturation of new-born's gastrointestinal tract. Colostrum has exerted posi...
mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function [0.03%]
雷帕霉素通过抑制mTORC1加剧肥胖小鼠的脂肪组织炎症并解离巨噬细胞表型与功能的关系
Vivian A Paschoal,Mariane T Amano,Thiago Belchior et al.
Vivian A Paschoal et al.
Genetic- and diet-induced obesity and insulin resistance are associated with an increase in mechanistic target of rapamycin complex (mTORC) 1 activity in adipose tissue. We investigated herein the effects of pharmacological mTORC1 inhibitio...
The pertussis hypothesis: Bordetella pertussis colonization in the pathogenesis of Alzheimer's disease [0.03%]
百日咳病原体假说：百日咳博德特氏菌在阿尔茨海默病发病机制中的定植作用
Keith Rubin,Steven Glazer
Keith Rubin
While a number of endogenous risk factors including age and genetics are established for Alzheimer's disease (AD), identification of acquired, potentially preventable or treatable causes, remains limited. In this paper, we review three epid...
Regulation of Siglec-8-induced intracellular reactive oxygen species production and eosinophil cell death by Src family kinases [0.03%]
Src家族激酶调节Siglec-8诱导的内源性活性氧产生及嗜酸性粒细胞死亡
Gen Kano,Bruce S Bochner,Nives Zimmermann
Gen Kano
Rationale: Siglec-8 is a surface receptor predominantly expressed on human eosinophils where its ligation induces reactive oxygen species (ROS) formation and cell death. Since Siglec-8 has intracellular tyrosine-based mot...
Jelka Gabrilovac,Barbara Čupić,Emilija Zapletal et al.
Jelka Gabrilovac et al.
Background: Dipeptidyl peptidase 9 (DPP9) is a relatively new member of the DPPIV family of prolyl dipeptidases which is ubiquitously expressed. Its role in regulation of immune responses and proliferation of epithelial c...
The T>A (rs11646213) gene polymorphism of cadherin-13 (CDH13) gene is associated with decreased risk of developing hypertension in Mexican population [0.03%]
墨西哥人群中的Cadherin-13(CDH13)基因中T>A（rs11646213）多态性与降低高血压发病风险有关
Gilberto Vargas-Alarcon,Nancy Martinez-Rodriguez,Rafael Velazquez-Cruz et al.
Gilberto Vargas-Alarcon et al.
Hypertension is a major public health problem affecting about 30% of the adult population and is associated with an increased risk of developing metabolic and cardiovascular disease. Recent reports have shown that the T-cadherin receptor ch...
IFN-γ-producing Th1-like regulatory T cells may limit acute cellular renal allograft rejection: Paradoxical post-transplantation effects of IFN-γ [0.03%]
产生IFN-γ的Treg细胞可能限制急性同种异体肾移植排斥反应：IFN-γ对移植后的矛盾效应
Xiaoguang Xu,Haiyan Huang,Qiang Wang et al.
Xiaoguang Xu et al.
Purpose: IFN-γ is a protypical proinflammatory cytokine that plays a central role in inflammation and acute graft rejection. Accumulating evidence indicates that IFN-γ can exert previously unexpected immunoregulatory ac...
Role of invariant NKT cells in lipopolysaccharide-induced lethal shock during encephalomyocarditis virus infection [0.03%]
乳多糖诱导致死性休克小鼠脑心肌炎病毒感染中不变自然杀伤T细胞的作用研究
Tatsuya Ando,Hiroyasu Ito,Hirofumi Ohtaki et al.
Tatsuya Ando et al.
Viral infections can give rise to secondary bacterial infections. In the present study, we examined the role of invariant natural killer T (iNKT) cells in lipopolysaccharide (LPS)-induced lethal shock during encephalomyocarditis virus (EMCV...
Epigenetic regulation of pro-inflammatory cytokine genes in lipopolysaccharide -stimulated peripheral blood mononuclear cells from broilers [0.03%]
脂多糖刺激下broiler鸡外周血单个核细胞中促炎性细胞因子基因的表观遗传学调控
Jing Shen,Shengru Wu,Wei Guo et al.
Jing Shen et al.
Inflammatory response which can be mediated by inflammatory genes, can be induced by pathogenic microorganisms, be associated with enteric diseases and the loss of growth performance in broilers. The understanding of epigenetic regulation o...
c-Rel is dispensable for the differentiation and functional maturation of M cells in the follicle-associated epithelium [0.03%]
C-Rel对滤泡相关上皮中M细胞的分化和功能成熟是可有可无的
Anuj Sehgal,Atsushi Kobayashi,David S Donaldson et al.
Anuj Sehgal et al.
M cells reside within the follicle-associated epithelium (FAE) overlying the gut-associated lymphoid tissues. These unique phagocytic epithelial cells enable the mucosal immune system to sample antigens within the lumen of the intestine. Th...