Integrated single-cell and bulk RNA-seq analysis identifies BCAA metabolism-related prognostic signatures in head and neck squamous cell carcinoma [0.03%]
整合单细胞和批量RNA测序分析识别头颈鳞状细胞癌中与BCAA代谢相关的预后标志物
Dandan Lu,Yongjun Liang,Tao Mo et al.
Dandan Lu et al.
Background: Impaired metabolism of branched-chain amino acids (BCAAs) has been linked to cancer progression; however, the specific mechanisms underlying BCAA metabolism in head and neck squamous cell carcinoma (HNSCC) rem...
Comprehensive bioinformatic and experimental approaches to analyze miR-200a, miR-1, and miR-548-3p expression and their targeted oxidative stress and glucose metabolic related hub genes in rheumatoid arthritis [0.03%]
全面的生物信息学和实验方法分析类风湿关节炎中miR-200a、miR-1 和 miR-548-3p 的表达及其靶向氧化应激和糖酵解代谢相关关键基因
B Alzahrani,B Rauff,M R Chaudhry et al.
B Alzahrani et al.
Rheumatoid arthritis is a chronic autoimmune disorder characterized by persistent synovial inflammation, oxidative stress, and metabolic reprogramming. Emerging evidence highlights miRNAs as key post-transcriptional regulators linking these...
High serum uric acid is linked with diabetic kidney disease progression: Evidence from Mendelian randomization analysis and animal study [0.03%]
高血尿酸与糖尿病肾脏病进展相关：基于孟德尔随机化分析和动物实验的证据
Xiaoxian Li,Yujie Peng,Wei Zhang et al.
Xiaoxian Li et al.
Background: Diabetic kidney disease (DKD) is a serious condition associated with diabetes, and the role of uric acid (UA) in its development remains debated. ...
The alterations of blood immune subpopulations, cytokines, and metabolites in anti-acetylcholine receptor antibody-positive myasthenia gravis: a real-world, observational, high-throughput study [0.03%]
抗乙酰胆碱受体抗体阳性重症肌无力患者血液免疫亚群、细胞因子及代谢物变化的高通量真实世界观察研究
Huanyu Meng,Xiaoyu Chen,Zhuoying Zhu et al.
Huanyu Meng et al.
Comprehensive profiling of peripheral blood may reveal candidate markers and therapeutic targets for anti-AChR antibody positive myasthenia gravis (MG) patients. We enrolled 37 anti-AChR antibody positive MG patients and 37 healthy controls...
Highlighting the changes of the Lymphocyte-to-Monocyte ratio in B-cell non-Hodgkin Lymphoma with the treatment and its association with the FLT3/FLT3LG system [0.03%]
B细胞非霍奇金淋巴瘤治疗过程中淋巴细胞与单核细胞比值的动态变化及其与FLT3/FLT3LG系统的关系分析
C K Nandasena,P W D C C Jayathilake,H A S G Dharmarathne et al.
C K Nandasena et al.
Background: B-cell Non-Hodgkin Lymphoma (B-NHL) is a group of lymphoid malignancies characterized by dysregulation of lymphocytes and monocytes. CD135/FLT3 (FMS-like tyrosine kinase 3) and its ligand (FLT3LG) play crucial...
Identification and structural characterization of soluble dectin-1 with β-glucan-binding activity in THP-1 cell culture supernatant [0.03%]
人单核细胞白血病细胞株THP-1培养上清中可溶性dectin-1的鉴定及结构分析
Naoki Arima,Rui Tada,Ken-Ichi Ishibashi et al.
Naoki Arima et al.
Dectin-1, a major receptor in antifungal immunity, functions as membrane-bound Dectin-1 (mDectin-1). However, the biological functions of its soluble form, sDectin-1, remain poorly understood. In this study, we established a THP-1 cell line...
Association of anti-DFS70 positivity with disease activity in systemic lupus erythematosus, Sjögren's syndrome, and systemic sclerosis: a cross sectional study [0.03%]
抗DFS70阳性与系统性红斑狼疮、舍格伦综合征和系统性硬化症疾病活动度的关系：一项横断面研究
Esra Dilsat Imrak,Alev Cetin Duran
Esra Dilsat Imrak
Objective: Anti-DFS70 antibodies have been proposed as a potential marker of lower disease activity in systemic autoimmune diseases, but evidence remains conflicting. This study aimed to investigate the association betwee...
A novel mitochondrial-related signature to decode tumor immunity and predict survival in chromophobe renal cell carcinoma [0.03%]
一种新的线粒体相关特征解码透明细胞肾细胞癌的肿瘤免疫并预测预后
Shuting Huang,Congcong Dai,Xia Li et al.
Shuting Huang et al.
Chromophobe renal cell carcinoma (chRCC) comprises about 5%-10% of all renal cancer cases, some of which are aggressive and metastatic. Mitochondria are significantly activated in chRCC, however, a risk model based on mitochondrial-related ...
Low-abundance plasma proteomics reveals NET-associated molecular signatures in rheumatoid arthritis [0.03%]
基于血浆蛋白质组揭示风湿关节炎中NETs相关分子特征
Feng Zhu,Wei Zhang,Xuejia Zheng et al.
Feng Zhu et al.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation and multi-organ involvement, yet its molecular mechanisms remain incompletely understood. While plasma proteomic...
ARID1A mutation is associated with an immunosuppressive microenvironment and poor prognosis in hepatocellular carcinoma: An integrated bioinformatics analysis [0.03%]
ARID1A突变与肝细胞癌免疫抑制型微环境及不良预后相关：综合生物信息学分析
Manxian Huang,Xiaobing Wan,Hong Chen et al.
Manxian Huang et al.
Background: Identifying recurrent genetic mutations is crucial for advancing the understanding and treatment of hepatocellular carcinoma (HCC). The chromatin regulator ARID1A is frequently mutated in cancers, but its inte...