Copper regulates the expression of immune genes in microglial cells in vitro [0.03%]
铜通过体外实验调节小胶质细胞的免疫基因表达
Laura Craciun,Sandra E Muroy,Kaoru Saijo
Laura Craciun
Copper, a transition metal, plays crucial roles in various physiological functions, including those of the nervous and immune systems. Dysregulation of copper homeostasis is linked to several diseases, such as neurodegenerative diseases. Si...
Measuring mRNA expression level of viral genes, IRF3/7 and TLR7/8 during BK polyomavirus infection in kidney transplant recipients [0.03%]
肾移植受者中BK多瘤病毒感染期间病毒基因、IRF3/7和TLR7/8的mRNA表达水平测定
Amin Zahmatkesh,Ramin Yaghobi,Ilnaz Sahragard et al.
Amin Zahmatkesh et al.
Background: Human BK polyomavirus (BKV) infection is a dangerous pathogenic factor in kidney transplant recipients (KTRs) due to the use of immunosuppressive drugs, which can cause damage to the transplanted kidneys after...
The expression of OX40 in CD4+ T cells and its association with hepatic fibrosis injury [0.03%]
CD4+T细胞OX40的表达及其与肝纤维化损伤的关系研究
YaLing Xu,WenNa Li,Yuan Li et al.
YaLing Xu et al.
Purpose: OX40 is a typical member of the co-stimulatory molecule family. The signals generated by its binding to OX40L have a synergistic effect, regulating T cell proliferation, differentiation, and influencing cytokine ...
Higher levels of urinary extracellular vesicles and immune mediators are related to acute infection severity during the post-COVID period [0.03%]
尿液胞外囊泡和免疫介导物的高水平与COVID后急性感染严重程度有关
Evelyn Maciel de Oliveira,Camila Carvalho,Natalia Fonseca do Rosário et al.
Evelyn Maciel de Oliveira et al.
Introduction: We investigated circulating and urinary inflammatory mediators and extracellular vesicles (EVs) in association with clinical and laboratory findings during the post-COVID-19 (coronavirus disease 2019) period...
NLRX1 as a novel therapeutic target: TRAF6-dependent inhibition of acute rejection in rat liver transplantation [0.03%]
NLRX1作为新治疗靶点的潜在作用：在大鼠肝移植中依赖TRAF6抑制急排反应
Zilun Lei,Tong Mou,Hao Chai et al.
Zilun Lei et al.
Recent research has underscored NLRX1's role in modulating hepatic immune responses. However, its function in Kupffer cells (KCs) during acute rejection (AR) post-liver transplantation is not well elucidated, and the mechanisms driving hepa...
Absence of complement terminal pathway activity in C6-deficient mice prolongs survival in a mouse model of severe malarial infection [0.03%]
溶血终末补体途径在小鼠重度疟疾感染模型中的致病作用
Tomoaki Kamiya,Yuki Miyasaka,Hangsoo Kim et al.
Tomoaki Kamiya et al.
Background: Malaria is an important and serious parasite-induced disease associated with severe anemia and multiple organ failure (MOF) that can be lethal in humans. We explored the contribution of the terminal pathway of...
The Role of WNT5A-mediated proteomic and phosphoproteomic regulatory networks in rheumatoid arthritis [0.03%]
WNT5A介导的蛋白质组和磷酸化蛋白质组调控网络在类风湿关节炎中的作用
Ping Jiang,Daxi Ma,Youji Jia et al.
Ping Jiang et al.
Objective: This study aims to investigate the role of the WNT5A signaling pathway in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) and uncover the impact of WNT5A on cellular function and signal transductio...
The anti-tumor and immunomodulatory effect of α-tocopherol on tumor microenvironment in an in vitro model of colon cancer [0.03%]
α-维生素E对体外结肠癌肿瘤微环境的抗肿瘤和免疫调节作用
Tahereh Azari,Fatemeh Sadeghi,Kosar Malekpour et al.
Tahereh Azari et al.
Background: Colorectal cancer (CRC) requires effective preventive measures due to its high prevalence, mortality rate, and impact on patients' lives. Therefore, this study aimed to assess the immunomodulatory effects of ...
Role of IL33/HIF1α/VEGF in intermittent hypoxia-induced lung injury [0.03%]
间断性缺氧致肺损伤的IL33/HIF1α/VEGF轴作用机制研究
Yan Zhang,Wen-Yan Yu,Zhi-Xing Ma et al.
Yan Zhang et al.
Objective: To investigate the role of IL33/HIF1α/VEGF in lung tissue injury caused by intermittent hypoxia (IH) model in mice, and to reveal its possible mechanisms. ...
Predictive value of NKG2A+ NK cell population in diagnosing severe COVID-19 patients [0.03%]
NKG2A+NK细胞群预测严重新冠肺炎患者的价值研究
Chunqiu Yang,Rui Qian,Mengtao Gong et al.
Chunqiu Yang et al.
Objectives: To evaluate the predictive value of NKG2A+ natural killer (NK) cells in identifying patients at risk of developing severe COVID-19 and assess the therapeutic potential of NKG2A blockade in restoring NK cell an...