Inhibition of miR-1-3p alleviates intrauterine adhesion in rats by promoting autophagy and suppressing pyroptosis in endometrial epithelial cells through targeting Sirt3 [0.03%]
抑制miR-1-3p通过靶向Sirt3促进自噬和抑制焦亡来缓解大鼠子宫粘连
Xuelan Yan,Lei Nian,Lingjing Zhu et al.
Xuelan Yan et al.
Background and purpose: Intrauterine adhesion (IUA) is a prevalent gynecological disorder that causes infertility and recurrent miscarriage; however, effective treatments remain limited. This study aimed to elucidate the ...
Differential parental exposure to polystyrene microplastics from weaning period to maturity: Immune homeostasis dysregulation in F1 offspring [0.03%]
从断奶期到成熟期不同剂量微塑料（聚苯乙烯）颗粒暴露的性别差异：F1代免疫稳态失调
Lili Cui,Shuangshuang Yang,Yuyan Ding et al.
Lili Cui et al.
The effects of long-term parental microplastic exposure on offspring immunity remain unclear. This study investigated how different parental exposure patterns affect immune status in F1 offspring. Parental rats were divided into four groups...
Integrative multi-omics analysis identifies AIF1 as an immune-associated factor linked to monocyte-centered inflammatory networks in Alzheimer's disease [0.03%]
整合多组学分析发现AIF1是与阿尔茨海默病单核细胞中心炎症网络相关的免疫相关因素
Qian Li,Mingjian Li,Xi Huang et al.
Qian Li et al.
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder in which immune dysregulation has emerged as an important component of disease pathogenesis; however, the contribution of circulating proteins and their cellular contex...
Research progress on the diagnostic value of ANCA in autoimmune diseases of patients with refractory rhinosinusitis [0.03%]
抗中性粒细胞胞浆抗体在难治性鼻窦炎自身免疫性疾病诊断价值的研究进展
Qian Li,Hang Li,Haiyuan Zhao
Qian Li
Anti-neutrophil cytoplasmic antibody (ANCA) is an important serological marker for autoimmune diseases, particularly ANCA-associated vasculitis (AAV). AAV frequently presents with refractory rhinosinusitis as an initial manifestation, yet A...
Discovery of a prognostic two-lncRNA panel correlated with immune-associated transcripts for forecasting overall survival in pancreatic cancer [0.03%]
用于预测胰腺癌总体生存率的与免疫相关转录本相关的预后两长链非编码RNA面板的发现
Hajar Eftekhari,Arash Safarzadeh,Emad Babakhanzadeh et al.
Hajar Eftekhari et al.
Background: Pancreatic cancer is among the most lethal cancers because of late diagnosis and inadequate therapeutic preferences. The tumor microenvironment and immune response have critical roles in disease progression an...
Changes of systemic immune cells subtypes in colorectal carcinoma patients [0.03%]
结直肠癌患者的系统性免疫细胞亚型变化
Khin Aye Thin,Andrew Cross,Phonthep Angsuwatcharakon et al.
Khin Aye Thin et al.
Background: Colorectal cancer (CRC) can induce stresses on the immune system that can affect both the numbers and function of immune cells. Changes in immune cell functions can also occur during ageing and these may affec...
The T cell receptor associated transmembrane adaptor 1 regulates the threshold for activation of naïve human CD4+ T cells [0.03%]
T细胞受体相关跨膜衔接分子1调节 naive人CD4+T细胞的活化阈值
Xiaolei Wang,Yuxia Zhang,Esther Bandala-Sanchez et al.
Xiaolei Wang et al.
T cell fate is partly determined by T cell receptor (TCR) affinity for its cognate peptide ligand. During thymic selection, CD4+ T cells with higher affinity for self-antigens are more likely to be deleted or become FOXP3+ natural T regulat...
Neutrophil-to-HDL-C ratio and systemic inflammation response index are associated with the risk of abdominal aortic aneurysm [0.03%]
中性粒细胞-HDL胆固醇比率和全身炎症反应指数与腹主动脉瘤风险相关
Junqi Peng,Dengwei Cao,Yun Wu et al.
Junqi Peng et al.
Abdominal aortic aneurysm (AAA) is characterized by an inflammatory response that plays a crucial role in its pathogenesis. This study aimed to investigate the association between novel circulating inflammatory biomarkers and AAA. A total o...
Integrating Bulk and Single-Cell RNA Sequencing to Identify Prognostic Genes Associated with Adaptive Immunity and the Tumor Microenvironment in Cholangiocarcinoma for Risk Model Construction [0.03%]
整合大队列和单细胞RNA测序鉴定与胆管癌适应性免疫及肿瘤微环境相关预后基因构建风险模型
Wang Jie,Zhou Jixiang,Bao Yang et al.
Wang Jie et al.
Background: Cholangiocarcinoma (CCA) has a complex tumor microenvironment (TME) and poor immunotherapy response. Understanding how the adaptive immune response (AIR) affects the TME and prognosis is critical. ...
Exogenous recombinant complement proteins C3a and C5a regulate osteogenic differentiation of P-PDLSCs: a process associated with the Wnt/beta-catenin axis [0.03%]
外源性补体蛋白C3a和C5a通过Wnt/β-catenin信号轴调节P-PDLSC成骨分化：一项相关过程的研究
Lingyan Peng,Yong Zhang,Xiaohui Yin et al.
Lingyan Peng et al.
Objective: Concentrated growth factor (CGF) is rich in growth factors and complement proteins like C3a and C5a, showing promise for enhancing tissue regeneration. This study explores the regulatory effects of recombinant ...