Hepatic interleukin-6 production is maintained during endotoxin tolerance and facilitates lipid accumulation [0.03%]
内毒素耐受期间肝细胞仍能产生白细胞介素6并促进脂质积累
Anna Dembek,Stephan Laggai,Sonja M Kessler et al.
Anna Dembek et al.
Gut-derived bacterial endotoxins, such as lipopolysaccharide (LPS), contribute to the pathogenesis of steatosis and steatohepatitis by activating Kupffer cells, the resident liver macrophages. Exposure of macrophages to low doses of LPS cau...
Treponema pallidum flagellins elicit proinflammatory cytokines from human monocytes via TLR5 signaling pathway [0.03%]
梅毒密螺旋体鞭毛蛋白通过TLR5信号途径诱导单核细胞产生促炎症细胞因子
Man Xu,Yafeng Xie,Chuanhao Jiang et al.
Man Xu et al.
The tissue damage caused by syphilis infection may be associated with inflammation. However, the virulence factors of Treponema pallidum are still unclear, nor are the molecular mechanisms for leading to the productions of proinflammatory c...
NLRC5 polymorphism is associated with susceptibility to chronic periodontitis [0.03%]
NLRC5多态性与慢性牙周炎易感性的关联研究
Luisa Zupin,Chiara Ottavia Navarra,Antonietta Robino et al.
Luisa Zupin et al.
Periodontitis is a chronic oral pathology caused by impaired immune response against oral bacteria resulting in tissue inflammation and damage. Among the members of innate immune response, the first line of defence against pathogens, inflam...
Anomalies in the dominant sarcoidosis paradigm justify its displacement [0.03%]
主流肉芽肿性血管炎诊断范式的异端及其替代理论的合理性
Jerome M Reich
Jerome M Reich
The prevailing paradigm defines sarcoidosis as a disease of unknown etiology characterized by a systemic noncaseating epithelioid granulomatous response (SGR). This formulation fails to account for the elusiveness of the etiological agent, ...
Pertussis toxin targets the innate immunity through DAP12, FcRγ, and MyD88 adaptor proteins [0.03%]
百日咳毒素通过DAP12、FcRγ和MyD88衔接蛋白作用于先天免疫系统
Vongsavanh Phongsisay,Ei&#x;ichi Iizasa,Hiromitsu Hara et al.
Vongsavanh Phongsisay et al.
Activation of the innate immunity by adjuvants, such as pertussis toxin (PTX), in the presence of autoreactive lymphocytes and antigen mimicry is sufficient to trigger autoimmunity. Toll-like, C-type lectin, and immunglobulin-like receptors...
Inflammatory early events associated to the role of P2X7 receptor in acute murine toxoplasmosis [0.03%]
P2X7受体在急性小鼠弓形虫病早期炎症事件中的作用相关性研究
Gladys Corrêa,Carolina de Almeida Lindenberg,Aline Cristina de Abreu Moreira-Souza et al.
Gladys Corrêa et al.
Activation of the purinergic P2X7 receptor by extracellular ATP (eATP) potentiates proinflammatory responses during infections by intracellular pathogens. Extracellular ATP triggers an antimicrobial response in macrophages infected with Tox...
Short term memory of Caenorhabditis elegans against bacterial pathogens involves CREB transcription factor [0.03%]
秀丽隐杆线虫对细菌病原体的短期记忆涉及CREB转录因子
Udayakumar Prithika,Ramaraj Vikneswari,Krishnaswamy Balamurugan
Udayakumar Prithika
One of the key issues pertaining to the control of memory is to respond to a consistently changing environment or microbial niche present in it. Human cyclic AMP response element binding protein (CREB) transcription factor which plays a cru...
The effects of increased heme oxygenase-1 on the lymphoproliferative response in dogs with visceral leishmaniasis [0.03%]
增加的血红素氧合酶-1对利什曼病犬淋巴增生反应的影响
Breno Fernando Martins de Almeida,Kathlenn Liezbeth Oliveira Silva,Vanessa Marim Chiku et al.
Breno Fernando Martins de Almeida et al.
Canine visceral leishmaniasis (CVL) is known to affect the cellular immunity of infected dogs, through impairing lymphoproliferation and microbicidal mechanisms. This study examined heme oxygenase-1 (HO-1) and its metabolites, oxidative str...
A specific immune tolerance toward offspring cells is to exist after the mother lymphocyte infusion [0.03%]
关于母体淋巴细胞输注后子代特异性免疫耐受存在的研究
Haizhou Xing,Shiqin Liu,Xue Chen et al.
Haizhou Xing et al.
Purpose: To examine immune tolerance between maternal lymphocytes and offspring tissue after a donor lymphocyte infusion. Methods: Mous...
Oral squamous cell carcinoma suppressed antitumor immunity through induction of PD-L1 expression on tumor-associated macrophages [0.03%]
口腔鳞状细胞癌通过诱导肿瘤相关巨噬细胞PD-L1表达来抑制抗肿瘤免疫反应
Canhua Jiang,Fulai Yuan,Jie Wang et al.
Canhua Jiang et al.
Oral squamous cell carcinoma (OSCC) is the most common solid tumor in the oral cavity. Development and progression of OSCC is associated with the elevated presence of inhibitory M2 type tumor-associated macrophages (TAMs). However, the unde...