Hepatic interleukin-6 production is maintained during endotoxin tolerance and facilitates lipid accumulation
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Gut-derived bacterial endotoxins, such as lipopolysaccharide (LPS), contribute to the pathogenesis of steatosis and steatohepatitis by activating Kupffer cells, the resident liver macrophages. Exposure of macrophages to low doses of LPS causes hyporesponsivene... ...
