Prenatal and adolescent exposure to metals/metalloids and telomere dynamics at 14 years: Evidence from the Chitwan birth cohort [0.03%]
一项关于出生队列中孕期和青少年时期接触金属/类金属与14岁时端粒动力学的证据研究
Kyi Mar Wai,Rajendra Prasad Parajuli,Masahiro Umezaki
Kyi Mar Wai
Telomeres are repetitive non-coding DNA sequences at chromosome ends that progressively shorten with each cell division, serving as markers of cellular aging. Recent studies have suggested that prenatal and postnatal exposure to metals/meta...
Cytotoxic, genotoxic, and apoptotic effects of manganese nitrate on RAW264.7 macrophages via reactive oxygen species accumulation and mitochondrial injury [0.03%]
硝酸锰通过活性氧积累和线粒体损伤途径对RAW264.7巨噬细胞的细胞毒性、遗传毒性和诱导凋亡作用
Ping-Kun Tsai,Sheng-Wen Wu,Yen-Ju Lee et al.
Ping-Kun Tsai et al.
Background: Manganese (Mn) is an essential trace element involved in multiple physiological processes. However, excessive Mn exposure is well known to induce neurotoxicity and has been extensively studied in neuronal and ...
Exposure to copper induces oxidative stress and apoptosis in human MEG-01 cells [0.03%]
铜暴露诱导人类MEG-01细胞氧化应激和凋亡
Zhanqin Huang,Yuxuan Huang,Hongxing Chen et al.
Zhanqin Huang et al.
Background: Wilson disease (WD), caused by ATP7B mutations, leads to pathological copper accumulation. Although thrombocytopenia is often reported in patients with WD, the underlying mechanisms are complex and remain unel...
Divulging the hidden risks of trace and heavy elements in sports nutritional supplements; a comprehensive study targeted with health risk evaluation [0.03%]
揭秘运动营养补剂中痕量和微量元素的隐性风险——以健康风险评估为目标的全面研究
Adel Ehab Ibrahim,Samy G Alamir,Mohamed Al-Omairi et al.
Adel Ehab Ibrahim et al.
Background: The sports dietary supplements market is growing globally, with a typical 36-85% of athletes consuming these products. Various types of products are being marketed under different classes. However, as nutritio...
Synthesis, structural characterization, computational studies, and anticancer evaluation of novel rufloxacin Schiff base metal complexes with involvement of Mcl-1 modulation in breast cancer cells [0.03%]
新型罗氟司他的希夫碱金属配合物的合成、结构表征、计算研究及抗肿瘤评价及其在乳腺癌细胞中对Mcl-1的调控作用
Sherif M Abd El-Hamid,Mohammed S El-Gedamy,Abdelazim M A Abdelgawwad et al.
Sherif M Abd El-Hamid et al.
Background and objective: Breast cancer remains a leading cause of cancer-related mortality among women worldwide, emphasizing the urgent need for the development of novel and effective metal-based chemotherapeutics. This...
Sodium pentaborate pentahydrate ameliorates inflammaging-like phenotypes by modulating redox status in a D-galactose-induced accelerated aging rat model [0.03%]
通过调节氧化还原稳态改善D-半乳糖诱导的衰老大鼠模型中与炎症相关的衰老表型：五水偏硼酸钠的作用
Serdar Bora Bayraktaroglu,Pakize Neslihan Tasli,Burcu Can et al.
Serdar Bora Bayraktaroglu et al.
Boron is a bioactive trace element that influences cellular signaling by forming ester complexes with ribose-containing molecules, such as NAD and S-adenosylmethionine. Age associated chronic low-grade inflammation ('inflammaging') and oxid...
The metallic trinity: Understanding the roles and interplay of copper, zinc, and iron in pulmonary fibrosis - A comprehensive review [0.03%]
金属三元体：铜、锌和铁在肺纤维化中的作用及相互作用——全面综述
Chloe Shah,Zhe Lv,Ye Cui
Chloe Shah
Pulmonary fibrosis (PF) is a group of debilitating chronic lung diseases characterized by progressive scarring of the lung parenchyma. Despite advances in understanding its multifactorial pathogenesis, these insights have yet to translate i...
Associations between polycyclic aromatic hydrocarbon exposure, zinc status, and abnormal lipid profiles in the U.S. population [0.03%]
美国人口中多环芳烃暴露、锌状态和血脂异常之间的关系
Humairat H Rahman,Walker Toohey,Stuart H Munson-McGee
Humairat H Rahman
Background: Abnormal lipid profiles, including changes in triglycerides, cholesterol, and phospholipids, are key concerns in healthcare due to their involvement in essential physiological processes and cellular membrane s...
Titanium ion inhibits osteogenic ability of osteoblasts by up-regulating osteoblast Agt gene via macrophages [0.03%]
钛离子通过巨噬细胞促进成骨细胞AGT基因表达抑制成骨能力
Mao Shan Wang,Hai Feng Zhou,Huan Li et al.
Mao Shan Wang et al.
The pathological mechanism of poor osseointegration of implants caused by aseptic loosening of implants is unclear. This study investigated the changes in implant osseointegration induced by titanium ions and explored the relationship betwe...
Sodium perborate tetrahydrate triggers mitochondrial dysfunction in Leishmania infantum parasites and enhances antileishmanial activity in macrophages [0.03%]
过硼酸钠四水合物可诱导利什曼原虫线粒体功能障碍并增强巨噬细胞的抗利什曼活性
Zeynep Islek,Hazal Uraz,Hatice Ilke Ozeken et al.
Zeynep Islek et al.
Sodium Perborate Tetrahydrate (SPT) is a potent semimetal element possessing intrinsic antimicrobial activities against various microorganisms including protozoan parasites. The crucial role of boron in antimicrobial therapy is associated w...