Understanding Huntington protein aggregation in cell mimicking environments [0.03%]
类细胞模拟环境中的亨廷顿蛋白聚集的初步研究
Apurva Mishra,Pramit K Chowdhury
Apurva Mishra
Protein aggregation plays a crucial role in various neurodegenerative diseases, including Huntington's disease. Understanding the factors influencing aggregation kinetics is essential for deciphering disease mechanisms. This research paper ...
Lin Qi,Mark Isalan
Lin Qi
De novo proteins represent a challenging frontier at the intersection of evolutionary biology and synthetic biology. Broadly, the term encompasses two distinct categories: naturally evolved de novo proteins, which arise from previously non-...
Characterization of fatty acid biosynthesis in microalga Scenedesmus - from the perspective of biofuel production [0.03%]
从生物燃料生产角度表征微藻Scenedesmus中脂肪酸的合成特征
Harshit Kumar Sharma,Ma Belén Velázquez,Noelia Marchetti et al.
Harshit Kumar Sharma et al.
Scenedesmus quadricauda, a freshwater microalga, has gained attention for its high lipid accumulation potential. However, information on fatty acid (FA) biosynthesis pathways in Scenedesmus species remains limited. Biomass (1.010 gL-1) and ...
Solution-based studies on the contact between the complement receptor 3 ligand-binding domain and simvastatin [0.03%]
基于溶液的研究：补体受体3配体结合域与辛伐他汀的相互作用
Morten Hulbæk Fog,Violaine Hubert,Corinne Sanglar et al.
Morten Hulbæk Fog et al.
Simvastatin is a primary cholesterol-lowering medication, but it has also been reported to possess anti-inflammatory properties. Notably, the CD18 integrins are targets for simvastatin antagonism of ligand binding, which may affect leukocyt...
Evolution in neuropsychiatric cis-regulatory enhancers through human-specific neuronal mutations within transcription factor binding sites [0.03%]
通过人类特异性神经元突变在转录因子结合位点中进行顺式调控增强子的神经精神演化
Rabail Zehra Raza,Saad Raza,Sumayyah Naveed et al.
Rabail Zehra Raza et al.
cis-Regulatory elements (CREs) in multicellular genomes play a significant role in precise regulation of the genes. Increasing evidence has shown that alterations in CREs have had a drastic effect on the human brain evolution, neuronal cell...
The role of the N-terminal p.R56Q mutation in modulating oligomerization and chaperone activity of human αB-crystallin in relation to cardiomyopathy [0.03%]
N末端p. R56Q突变在人αB-晶状体寡聚化和分子伴侣活性及相关心肌病中的作用
Leila Rezaei Somee,Mansi Upadhyay,Rahul Shobhawat et al.
Leila Rezaei Somee et al.
αB-crystallin (αB-Cry), a critical small heat shock protein, is crucial for cellular proteostasis, especially in the heart and lens. αB-Cry mutations can disrupt its chaperone activity, leading to pathological conditions such as myopathy...
Corrigendum to 'Glycoproteomic characterization of Neuropilin-1 reveals critical glycosylation sites for SARS-CoV-2 entry' [Biochimica et Biophysica Acta (BBA) - proteins and proteomics 1873 (5) (2025) 141089] [0.03%]
“关于‘神经纤毛蛋白-1的糖蛋白质组学表征揭示了SARS-CoV-2进入的关键糖基化位点’[生物化学与生物物理学报（BBA）-蛋白质与蛋白质组学1873（5）（2025）141089]的勘误表
Tuhin Das,Shuhong Luo,Panning Wang et al.
Tuhin Das et al.
Self-association of Apolipoprotein A-I studied with multiple-association models: A pyrene multiparametric analysis [0.03%]
基于多参数模型的载脂蛋白A-I自缔合的倍加烯研究
Wilson A Tárraga,Lisandro J Falomir-Lockhart,Horacio A Garda et al.
Wilson A Tárraga et al.
Apolipoprotein A-I (apoA-I) is the main protein of high-density lipoprotein particles, conferring anti-atherogenic properties through reverse cholesterol transport. In its lipid-free state, apoA-I self-associates, a process implicated in no...
Structural insights of the complex formed by KRAS G12V and a novel TIG3 peptide [0.03%]
KRAS G12V 和新型TIG3肽复合物的结构洞察
Min Seon Ha,Chang Woo Han,Mi Suk Jeong et al.
Min Seon Ha et al.
Pancreatic cancer remains a severe malignancy with a dismal 5-year survival rate, and most pancreatic cancer patients harbor KRAS mutations, which are critical targets for anti-cancer drug development. However, the structural characteristic...
Role of N-terminal of metacaspase of Candida albicans in calcium binding [0.03%]
钙离子结合对白色念珠菌半胱天冬酶N端的作用研究
Taiz Dos Reis Santos,Mariana Nascimento Romero Trujilho,João Pedro Martins Silva Costa et al.
Taiz Dos Reis Santos et al.
Metacaspases are members of the CD clan and share structural similarities with mammalian caspases but possess unique features. This study delves into the Candida albicans metacaspase CaMCA-Ia, a type I metacaspase. CaMCA-Ia demonstrates Ca2...