The role of the N-terminal p.R56Q mutation in modulating oligomerization and chaperone activity of human αB-crystallin in relation to cardiomyopathy
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αB-crystallin (αB-Cry), a critical small heat shock protein, is crucial for cellular proteostasis, especially in the heart and lens. αB-Cry mutations can disrupt its chaperone activity, leading to pathological conditions such as myopathy, cardiomyopathy, an... ...
