Systematic identification of species-specific allosteric sites in bacterial glycolytic enzymes: Hexokinase, phosphoglucose isomerase, phosphoglycerate kinase, and enolase [0.03%]
细菌糖酵解酶种属特异性别构位点的系统鉴定：己糖激酶、葡萄糖-6-磷酸异构酶、 2-磷酸甘油酸激酶和烯醇酶
Defne Alnigenis,Florihana Brina,Ilknur Kocal et al.
Defne Alnigenis et al.
In this study, we developed and applied an integrative computational workflow for the systematic identification and prioritization of candidate allosteric pockets across all four glycolytic enzymes: three from Staphylococcus aureus-phosphog...
Subcellular proteomic analysis of the DDR2 interactome in a neuronal cell model exposed to Aβ42 [0.03%]
Aβ42暴露下神经元细胞模型中DDR2蛋白组相互作用网络的亚细胞定位分析
Russa Das,Debashis Mukhopadhyay
Russa Das
Receptor tyrosine kinases (RTKs) are increasingly understood to signal beyond the plasma membrane. However, the role of Discoidin domain receptor 2 (DDR2), which is activated by collagen, in neurodegeneration remains poorly understood. This...
Exploring the proteomic landscape of THP-1 monocytes through two-challenge LPS induction [0.03%]
LPS诱导THP-1单核细胞系蛋白质组景观的探索研究
Cassandra Cianciarulo,Ilona Turek,Siti Saleha Binte Mohamed Yakob Adil et al.
Cassandra Cianciarulo et al.
Proteome remodelling is central to the regulation of innate immune activation, yet the temporal organisation of protein networks engaged during repeated lipopolysaccharide (LPS) stimulation remains incompletely defined. In the present study...
Local energetic frustration: Protein evolution, conformational dynamics and design in the age of AI [0.03%]
局部能量挫折：在人工智能时代下的蛋白质演化、构象动力学及设计
Franco L Simonetti,Eli J Draizen,Rocío Espada et al.
Franco L Simonetti et al.
Proteins operate under competing demands imposed by stability, dynamics, and function, all of which are shaped by evolution. Local energetic frustration provides a quantitative framework to describe how these competing requirements are dist...
Next-generation brain proteomics: Integrating single-cell, spatial, and multi-omics for clinical biomarker discovery [0.03%]
下一代脑蛋白质组学：整合单细胞、空间和多组学技术以发现临床生物标志物
Arup Acharjee,Nitika Rai,Akash Patel et al.
Arup Acharjee et al.
The mammalian brain's functional complexity arises from the sophisticated architecture of neurons and glia. This network is essentially defined by its dynamic proteome, which reveals the functional execution underlying neural computation an...
tRNA methyltransferase (TRDMT1/DNMT2) participates in network of RNA modification in the Moss Physcomitrium patens [0.03%]
双链植物苔类(Polyphyscomitrium patens)中的tRNA甲基转移酶(TRDMT1 / DNMT2)参与RNA修饰网络
Yashika Kanojia,Darshika Singh,Nikita Wadhwa et al.
Yashika Kanojia et al.
Crosstalk among tRNA modification proteins have been implicated in important functional roles in biology. We previously reported that Physcomitrium tRNA (cytosine38-C5)-methyltransferase, TRDMT1/DNMT2 catalyses C38, C48 and C49 methylation ...
Mechanistic insights into the inhibition of α-synuclein aggregation by sugar-based nanoparticles [0.03%]
糖基纳米颗粒抑制α-突触核蛋白聚集的机制研究
Danish Alam,Tanzeel Khan,Iqra Sadiq et al.
Danish Alam et al.
The pathological accumulation of α-synuclein (α-syn) into amyloid fibrils is a key hallmark of Parkinson's disease and related synucleinopathies. Inhibiting the early stages of α-syn aggregation remains a major therapeutic challenge. In ...
Biochemical characterization and assay development for adenylosuccinate synthetase Rv0357c from Mycobacterium tuberculosis [0.03%]
结核分枝杆菌腺苷琥珀酸合成酶Rv0357c的生化表征及活性检测方法开发
Vigyasa Singh,Ran Zhang,Ke Chen et al.
Vigyasa Singh et al.
The global rise of drug-resistant Mycobacterium tuberculosis (Mtb) underscores an urgent need for antitubercular agents with novel targets and mechanisms of action. Among these, the de novo purine biosynthesis pathway is essential for Mtb g...
Activity-guided identification, cloning, heterologous expression, and characterization of a highly thermostable mitochondrial superoxide dismutase from Lantana camara [0.03%]
基于活性的鉴定、克隆、异源表达和表征来自于Lantana camara的高度耐热型线粒体超氧化物歧化酶
Himanshu,Mahima Chauhan,Mahesh Kulharia et al.
Himanshu et al.
Manganese superoxide dismutase (MnSOD), localized in the mitochondrial matrix, is considered pivotal enzyme in the mitochondrial powerhouse. This is primarily due to its central role in the scavenging of excess superoxide anions (O2-) produ...
In silico structural characterization of the geranyl pyrophosphate synthase (GPPS) large subunit from Catharanthus roseus [0.03%]
长春花Geranyl Pyrophosphate合酶(GPPS)大亚基的结构特征研究
Karunesh Yadav,Km Akanksha Gupta,Dinesh A Nagegowda et al.
Karunesh Yadav et al.
Catharanthus roseus, a medicinal plant known for its anti-cancer monoterpene indole alkaloids vinblastine and vincristine, possesses two distinct types of geranyl pyrophosphate synthases (GPPS). A homomeric GPPS synthesizes geranyl pyrophos...