Local energetic frustration: Protein evolution, conformational dynamics and design in the age of AI [0.03%]
局部能量挫折：在人工智能时代下的蛋白质演化、构象动力学及设计
Franco L Simonetti,Eli J Draizen,Rocío Espada et al.
Franco L Simonetti et al.
Proteins operate under competing demands imposed by stability, dynamics, and function, all of which are shaped by evolution. Local energetic frustration provides a quantitative framework to describe how these competing requirements are dist...
Next-generation brain proteomics: Integrating single-cell, spatial, and multi-omics for clinical biomarker discovery [0.03%]
下一代脑蛋白质组学：整合单细胞、空间和多组学技术以发现临床生物标志物
Arup Acharjee,Nitika Rai,Akash Patel et al.
Arup Acharjee et al.
The mammalian brain's functional complexity arises from the sophisticated architecture of neurons and glia. This network is essentially defined by its dynamic proteome, which reveals the functional execution underlying neural computation an...
tRNA methyltransferase (TRDMT1/DNMT2) participates in network of RNA modification in the Moss Physcomitrium patens [0.03%]
双链植物苔类(Polyphyscomitrium patens)中的tRNA甲基转移酶(TRDMT1 / DNMT2)参与RNA修饰网络
Yashika Kanojia,Darshika Singh,Nikita Wadhwa et al.
Yashika Kanojia et al.
Crosstalk among tRNA modification proteins have been implicated in important functional roles in biology. We previously reported that Physcomitrium tRNA (cytosine38-C5)-methyltransferase, TRDMT1/DNMT2 catalyses C38, C48 and C49 methylation ...
Mechanistic insights into the inhibition of α-synuclein aggregation by sugar-based nanoparticles [0.03%]
糖基纳米颗粒抑制α-突触核蛋白聚集的机制研究
Danish Alam,Tanzeel Khan,Iqra Sadiq et al.
Danish Alam et al.
The pathological accumulation of α-synuclein (α-syn) into amyloid fibrils is a key hallmark of Parkinson's disease and related synucleinopathies. Inhibiting the early stages of α-syn aggregation remains a major therapeutic challenge. In ...
Biochemical characterization and assay development for adenylosuccinate synthetase Rv0357c from Mycobacterium tuberculosis [0.03%]
结核分枝杆菌腺苷琥珀酸合成酶Rv0357c的生化表征及活性检测方法开发
Vigyasa Singh,Ran Zhang,Ke Chen et al.
Vigyasa Singh et al.
The global rise of drug-resistant Mycobacterium tuberculosis (Mtb) underscores an urgent need for antitubercular agents with novel targets and mechanisms of action. Among these, the de novo purine biosynthesis pathway is essential for Mtb g...
Activity-guided identification, cloning, heterologous expression, and characterization of a highly thermostable mitochondrial superoxide dismutase from Lantana camara [0.03%]
基于活性的鉴定、克隆、异源表达和表征来自于Lantana camara的高度耐热型线粒体超氧化物歧化酶
Himanshu,Mahima Chauhan,Mahesh Kulharia et al.
Himanshu et al.
Manganese superoxide dismutase (MnSOD), localized in the mitochondrial matrix, is considered pivotal enzyme in the mitochondrial powerhouse. This is primarily due to its central role in the scavenging of excess superoxide anions (O2-) produ...
In silico structural characterization of the geranyl pyrophosphate synthase (GPPS) large subunit from Catharanthus roseus [0.03%]
长春花Geranyl Pyrophosphate合酶(GPPS)大亚基的结构特征研究
Karunesh Yadav,Km Akanksha Gupta,Dinesh A Nagegowda et al.
Karunesh Yadav et al.
Catharanthus roseus, a medicinal plant known for its anti-cancer monoterpene indole alkaloids vinblastine and vincristine, possesses two distinct types of geranyl pyrophosphate synthases (GPPS). A homomeric GPPS synthesizes geranyl pyrophos...
Subhadwip Dey,Pooja Agarwal,Sachin Kumar
Subhadwip Dey
Arginylation is a well-known, evolutionarily conserved, and recognizable post-translational modification (PTM). In this modification, an arginine residue is enzymatically attached to the target residue, such as aspartic acid (D), glutamic a...
Atomistic mapping of the Sclerostin-LRP6 binding interface using molecular dynamics simulation and essential dynamics [0.03%]
基于分子动力学模拟和本质动力学的Sclerostin-LRP6结合位点原子映射研究
Mohammad Babelian,Yalda Azghandi,Faramarz Mehrnejad et al.
Mohammad Babelian et al.
This study investigates the molecular mechanism by which Sclerostin (SOST), a secreted cystine-knot protein with a structured core and functionally relevant highly flexible or intrinsically disordered regions (IDRs), inhibits the LRP6 co-re...
Plant uricase are evolutionarily conserved but functionally divergent: A case study of Oryza coarctata uricase [0.03%]
植物尿酸酶的进化是保守的功能分化：粟米草尿酸酶为例的研究
Nitasana Rajkumari,Soni Chowrasia,Yuvaraj Iyyappan et al.
Nitasana Rajkumari et al.
Allantoin plays a major role in nitrogen mobilization as well as abiotic stress tolerance in plants, and uricase enzyme is the key rate-limiting enzyme for the biosynthesis of allantoin in peroxisomes. However, the molecular mechanisms unde...