Identification of new protein-coding potential in Leishmania braziliensis using a proteogenomics approach [0.03%]
采用蛋白质组学方法鉴定新蛋白质编码潜能的利什曼原虫菌株 braziliensis
Aditi Shenoy,Soumi Chowdhury,Shubhankar Pawar et al.
Aditi Shenoy et al.
American tegumentary leishmaniasis (ATL) is primarily caused by Leishmania (Viannia) species such as Leishmania braziliensis, Leishmania panamensis, and Leishmania guyanensis, which show complex genomic organisation and stage-specific adapt...
LncRNA CERS6 - AS1 mediates the IGF2BP1/LIN28B axis to promote proliferation, migration and invasion in ovarian cancer [0.03%]
长链非编码RNA CERS6-AS1介导IGF2BP1/LIN28B轴促进卵巢癌细胞的增殖、迁移和侵袭
Jia Hang,Huiwen Sun,Chengzhen Gao et al.
Jia Hang et al.
Ovarian cancer remains a significant clinical challenge for women's health, making it imperative to elucidate its underlying molecular mechanisms. LncRNA CERS6-AS1 and LIN28B-binding proteins play a vital role in the development of ovarian ...
Flexibility in acidophilic thioredoxins: Insights from Asp43 substitutions in E. coli thioredoxin [0.03%]
酸嗜性硫氧还蛋白的灵活性——来自大肠杆菌硫氧还蛋白天冬氨酸43位点取代的启示
Oanh Mai Ho,Mohammed Shazaly A Elhassan,Khang Nguyen et al.
Oanh Mai Ho et al.
Thioredoxins (Trxs) are small, highly conserved oxidoreductases characterized by a redox-active CXXC motif. While the structural adaptation of modern Trxs such as Escherichia coli Trx (EcTrx) has been described, the mechanisms underlying Tr...
Molecular insights into diosgenin's role in preventing protein aggregation in neurodegenerative diseases [0.03%]
从分子角度探讨地奥辛防治神经退行性疾病蛋白聚集的作用机制
Nagma Parveen,Faizan Abul Qais,Mohammad Faheem
Nagma Parveen
Neurodegenerative disorders (ND) such as Parkinson's and Alzheimer's progressively impair the nervous system, leading to cognitive deterioration and motor dysfunction. A primary factor in these diseases is the accumulation of misfolded prot...
Integrated computational and biological assays to identify and validate L. donovani homoserine dehydrogenase inhibitors [0.03%]
计算与生物综合检测方法鉴定和验证莱姆病同型半胱氨酸脱氢酶抑制剂
Shalu Verma,Shaswat Sengar,Abdul Basit Khan et al.
Shalu Verma et al.
The Neglected Tropical Disease (NTD) Leishmaniasis continues to pose a serious global health burden affecting millions globally. Visceral leishmaniasis, one of three clinical forms, can be fatal, if left untreated. Current treatment regimen...
Enhancement of the nucleotide incorporation activity of the terminal deoxynucleotidyl transferase by N-terminal truncation and DNA-binding protein modulation [0.03%]
通过N端截断和DNA结合蛋白调节增强末端脱氧核苷酸转移酶的核苷酸掺入活性
Antos B Sachanka,Stafaniya S Douhaya,Veronika V Shchur et al.
Antos B Sachanka et al.
Terminal deoxynucleotidyl transferase (TdT) is a unique DNA polymerase that catalyzes the template-independent addition of nucleotides to the 3' terminus of single-stranded DNA. Its distinctive catalytic properties have been exploited in ap...
Integrative multi-omics machine learning reveals novel driver genes associations in lung adenocarcinoma [0.03%]
整合多组学机器学习发现肺癌腺癌新的驱动基因关联
Fei Yuan,FeiMing Huang,Xiaoyu Cao et al.
Fei Yuan et al.
Lung adenocarcinoma remains a major challenge in cancer research due to its complex molecular underpinnings. In this study, we developed an integrated machine learning framework to identify novel driver genes associated with lung adenocarci...
Novel interactions between FOXP2 and PAX6: Implications for neural development and autism spectrum disorders [0.03%]
FOXP2与PAX6之间的新互作对神经发育和自闭症的影响
Jessica Brothwell,Olamide Jeje,Dineo Mashamaiete et al.
Jessica Brothwell et al.
FOXP2 and PAX6 are transcription factors essential for neural development, with mutations in both linked to autism spectrum disorders (ASDs). Their DNA-binding domains include a forkhead domain (FHD) for FOXP2 and a paired domain (PD) plus ...
Jaimini Patoliya,Khushali Thaker,Jahanvi Bajapai et al.
Jaimini Patoliya et al.
Xanthomonas oryzae pv. oryzae (Xoo), the causative agent of bacterial blight in rice, secretes a suite of effectors via the Type III Secretion System (T3SS), among which harpin proteins like Hpa1 are key modulators of plant immunity. Unlike...
Drug-biomolecular interaction: Spectroscopic and computational insights into esomeprazole binding with human serum albumin [0.03%]
埃索美拉唑与人血清白蛋白相互作用的光谱及计算研究
Anna Tanuja Safala Bodapati,Ragaiahgari Srinivas Reddy,Kandikonda Lavanya et al.
Anna Tanuja Safala Bodapati et al.
Cellular process relies on specific binding of drug molecules with desired biological receptors. Biomolecular receptors and drugs exhibit their biological functions upon their interactions. Understanding the binding parameters and energetic...