MetIoR: A meta predictor to predict intrinsic disorder in RNA binding proteins [0.03%]
基于元路径的蛋白质内在无序区预测方法MetIoR
Swarnadip Mitra,Ranjit Prasad Bahadur
Swarnadip Mitra
Intrinsic disorder in proteins is ubiquitous in nature across various proteomes. The association of intrinsically disordered proteins (IDP) with a large variety of biomolecules is essential in many cellular functions. Moreover, IDPs are inv...
Robert S Phillips,Xuan Tran,Brooke Mangano
Robert S Phillips
Salmonella enterica serover typhimurium expresses an ornithine racemase (OrnR), located in a small operon containing amino acid transporter homologues and D-ornithine/d-lysine decarboxylase. This OrnR is part of a clade that has high identi...
Comparative proteomic profiling of advanced, injectable, and titanium-prepared platelet rich fibrins (PRF): Insights into functional divergence and clinical potential [0.03%]
高级注射型和钛制备型富血小板纤维蛋白（PRF）的比较蛋白质组学分析：功能分化和临床应用的新见解
Sri Vidhya Marimuthu,Tamizhini Loganathan,Muthukumar Santhanakrishnan et al.
Sri Vidhya Marimuthu et al.
Platelet-rich fibrin (PRF) has emerged as a pivotal autologous biomaterial in regenerative medicine, yet comparative proteomic insights into its diverse formulations advanced PRF (A-PRF), injectable PRF (I-PRF), and titanium-prepared PRF (T...
Nitrated products formed on α-synuclein are preferentially incorporated into oligomers but excluded from fibrils: A mechanism for accumulation of neurotoxic species [0.03%]
α-突触核蛋白硝化产物优先掺入寡聚体但被排除出原纤维：毒性物种累积的机制
Daniel E Otzen,Luke F Gamon,Per Hägglund et al.
Daniel E Otzen et al.
Post-translational modifications (PTMs) such as nitration of Tyr (Y) residues and di-tyrosine (DT) formation are known to impact the aggregation behavior of α-synuclein (α-syn), a protein closely linked to Parkinson's disease. Using tetra...
Identification of new protein-coding potential in Leishmania braziliensis using a proteogenomics approach [0.03%]
采用蛋白质组学方法鉴定新蛋白质编码潜能的利什曼原虫菌株 braziliensis
Aditi Shenoy,Soumi Chowdhury,Shubhankar Pawar et al.
Aditi Shenoy et al.
American tegumentary leishmaniasis (ATL) is primarily caused by Leishmania (Viannia) species such as Leishmania braziliensis, Leishmania panamensis, and Leishmania guyanensis, which show complex genomic organisation and stage-specific adapt...
LncRNA CERS6 - AS1 mediates the IGF2BP1/LIN28B axis to promote proliferation, migration and invasion in ovarian cancer [0.03%]
长链非编码RNA CERS6-AS1介导IGF2BP1/LIN28B轴促进卵巢癌细胞的增殖、迁移和侵袭
Jia Hang,Huiwen Sun,Chengzhen Gao et al.
Jia Hang et al.
Ovarian cancer remains a significant clinical challenge for women's health, making it imperative to elucidate its underlying molecular mechanisms. LncRNA CERS6-AS1 and LIN28B-binding proteins play a vital role in the development of ovarian ...
Flexibility in acidophilic thioredoxins: Insights from Asp43 substitutions in E. coli thioredoxin [0.03%]
酸嗜性硫氧还蛋白的灵活性——来自大肠杆菌硫氧还蛋白天冬氨酸43位点取代的启示
Oanh Mai Ho,Mohammed Shazaly A Elhassan,Khang Nguyen et al.
Oanh Mai Ho et al.
Thioredoxins (Trxs) are small, highly conserved oxidoreductases characterized by a redox-active CXXC motif. While the structural adaptation of modern Trxs such as Escherichia coli Trx (EcTrx) has been described, the mechanisms underlying Tr...
Molecular insights into diosgenin's role in preventing protein aggregation in neurodegenerative diseases [0.03%]
从分子角度探讨地奥辛防治神经退行性疾病蛋白聚集的作用机制
Nagma Parveen,Faizan Abul Qais,Mohammad Faheem
Nagma Parveen
Neurodegenerative disorders (ND) such as Parkinson's and Alzheimer's progressively impair the nervous system, leading to cognitive deterioration and motor dysfunction. A primary factor in these diseases is the accumulation of misfolded prot...
Integrated computational and biological assays to identify and validate L. donovani homoserine dehydrogenase inhibitors [0.03%]
计算与生物综合检测方法鉴定和验证莱姆病同型半胱氨酸脱氢酶抑制剂
Shalu Verma,Shaswat Sengar,Abdul Basit Khan et al.
Shalu Verma et al.
The Neglected Tropical Disease (NTD) Leishmaniasis continues to pose a serious global health burden affecting millions globally. Visceral leishmaniasis, one of three clinical forms, can be fatal, if left untreated. Current treatment regimen...
Enhancement of the nucleotide incorporation activity of the terminal deoxynucleotidyl transferase by N-terminal truncation and DNA-binding protein modulation [0.03%]
通过N端截断和DNA结合蛋白调节增强末端脱氧核苷酸转移酶的核苷酸掺入活性
Antos B Sachanka,Stafaniya S Douhaya,Veronika V Shchur et al.
Antos B Sachanka et al.
Terminal deoxynucleotidyl transferase (TdT) is a unique DNA polymerase that catalyzes the template-independent addition of nucleotides to the 3' terminus of single-stranded DNA. Its distinctive catalytic properties have been exploited in ap...