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Flexibility in acidophilic thioredoxins: Insights from Asp43 substitutions in E. coli thioredoxin

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Thioredoxins (Trxs) are small, highly conserved oxidoreductases characterized by a redox-active CXXC motif. While the structural adaptation of modern Trxs such as Escherichia coli Trx (EcTrx) has been described, the mechanisms underlying Trx adaptation to acid... ...