Evolution in neuropsychiatric cis-regulatory enhancers through human-specific neuronal mutations within transcription factor binding sites [0.03%]
通过人类特异性神经元突变在转录因子结合位点中进行顺式调控增强子的神经精神演化
Rabail Zehra Raza,Saad Raza,Sumayyah Naveed et al.
Rabail Zehra Raza et al.
cis-Regulatory elements (CREs) in multicellular genomes play a significant role in precise regulation of the genes. Increasing evidence has shown that alterations in CREs have had a drastic effect on the human brain evolution, neuronal cell...
The role of the N-terminal p.R56Q mutation in modulating oligomerization and chaperone activity of human αB-crystallin in relation to cardiomyopathy [0.03%]
N末端p. R56Q突变在人αB-晶状体寡聚化和分子伴侣活性及相关心肌病中的作用
Leila Rezaei Somee,Mansi Upadhyay,Rahul Shobhawat et al.
Leila Rezaei Somee et al.
αB-crystallin (αB-Cry), a critical small heat shock protein, is crucial for cellular proteostasis, especially in the heart and lens. αB-Cry mutations can disrupt its chaperone activity, leading to pathological conditions such as myopathy...
Corrigendum to 'Glycoproteomic characterization of Neuropilin-1 reveals critical glycosylation sites for SARS-CoV-2 entry' [Biochimica et Biophysica Acta (BBA) - proteins and proteomics 1873 (5) (2025) 141089] [0.03%]
“关于‘神经纤毛蛋白-1的糖蛋白质组学表征揭示了SARS-CoV-2进入的关键糖基化位点’[生物化学与生物物理学报（BBA）-蛋白质与蛋白质组学1873（5）（2025）141089]的勘误表
Tuhin Das,Shuhong Luo,Panning Wang et al.
Tuhin Das et al.
Self-association of Apolipoprotein A-I studied with multiple-association models: A pyrene multiparametric analysis [0.03%]
基于多参数模型的载脂蛋白A-I自缔合的倍加烯研究
Wilson A Tárraga,Lisandro J Falomir-Lockhart,Horacio A Garda et al.
Wilson A Tárraga et al.
Apolipoprotein A-I (apoA-I) is the main protein of high-density lipoprotein particles, conferring anti-atherogenic properties through reverse cholesterol transport. In its lipid-free state, apoA-I self-associates, a process implicated in no...
Structural insights of the complex formed by KRAS G12V and a novel TIG3 peptide [0.03%]
KRAS G12V 和新型TIG3肽复合物的结构洞察
Min Seon Ha,Chang Woo Han,Mi Suk Jeong et al.
Min Seon Ha et al.
Pancreatic cancer remains a severe malignancy with a dismal 5-year survival rate, and most pancreatic cancer patients harbor KRAS mutations, which are critical targets for anti-cancer drug development. However, the structural characteristic...
Role of N-terminal of metacaspase of Candida albicans in calcium binding [0.03%]
钙离子结合对白色念珠菌半胱天冬酶N端的作用研究
Taiz Dos Reis Santos,Mariana Nascimento Romero Trujilho,João Pedro Martins Silva Costa et al.
Taiz Dos Reis Santos et al.
Metacaspases are members of the CD clan and share structural similarities with mammalian caspases but possess unique features. This study delves into the Candida albicans metacaspase CaMCA-Ia, a type I metacaspase. CaMCA-Ia demonstrates Ca2...
Glycoproteomic characterization of Neuropilin-1 reveals critical glycosylation sites for SARS-CoV-2 entry [0.03%]
神经纤毛蛋白-1的糖蛋白组学表征揭示了SARS-CoV-2进入的关键糖基化位点
Tuhin Das,Shuhong Luo,Panning Wang et al.
Tuhin Das et al.
The binding of the SARS-CoV-2 spike (S) glycoprotein to human host receptors, including ACE2, NRP1, and AXL, is essential for viral entry. Glycosylation of both the spike protein and its host receptors can significantly influence these inte...
Modulation of thermomechanical-induced albumin aggregation by extracts of Centella asiatica [0.03%]
羟基喜树碱脂质体的制备及其药代动力学研究
Laipubam Gayatri Sharma,Sanjana SenthilKumar,Latha Rangan et al.
Laipubam Gayatri Sharma et al.
In this study, Centella asiatica extracts obtained through sequential extraction in ethyl acetate (CEE), methanol (CME), and water (CWE) were explored for the inhibition of thermal and thermomechanical-induced aggregation of albumin. Th-T f...
Biochemical and kinetic properties of quinone oxidoreductase from Leishmania orientalis, a member of medium-chain dehydrogenase/reductase superfamily [0.03%]
沙粒菌东方利什曼原虫苯醌氧化还原酶的生化和动力学性质——中链脱氢酶/还原酶超家族成员
Panu Pimviriyakul,Sumita Harungsee,Theerapat Tangsupatawat et al.
Panu Pimviriyakul et al.
Soluble quinone oxidoreductase (QOR) is an attractive target for treating leishmaniasis. In this study, a QOR from Leishmania orientalis PCM2 (LoQOR) was identified as a member of nonZn2+ medium-chain dehydrogenase/reductase (MDR) superfami...
Human mitochondrial pyrophosphatase hPPA2: In vitro and in silico study of the factors affecting its function [0.03%]
人类线粒体焦磷酸酶hPPA2：影响其功能的因素的体内和体外研究
Svetlana Kurilova,Nataliya Vorobyeva,Ekaterina Bezpalaya et al.
Svetlana Kurilova et al.
Biallelic mutations in a nuclear gene PPA2 in human encoding mitochondrial inorganic pyrophosphatase hPPA2 cause mitochondrial disfunctions leading to severe cardiac pathology. This protein catalyzes a Mg2+-dependent hydrolysis of pyrophosp...