Computing pathogenicity of mutations in human cytochrome P450 superfamily [0.03%]
计算人类细胞色素P450超家族突变致病性的方法
Somnath Mondal,Pranchal Shrivastava,Rukmankesh Mehra
Somnath Mondal
Cytochrome P450 (CYPs) are crucial heme-containing enzymes that metabolize drugs and endogenous compounds. In humans, 57 CYP isoforms have been identified, with over 200 mutations linked to severe disorders. Our comprehensive computational ...
Parishin C modulates the amyloid transformation of alpha-synuclein protein by apparently interacting with the NAC domain [0.03%]
parishin C通过与NAC结构域相互作用来调节α-突触核蛋白的淀粉样转化
Almas Akhtar,Payal Singh,Nikita Admane et al.
Almas Akhtar et al.
Parkinson's disease (PD) is a neurodegenerative disorder marked by the gradual deterioration of dopaminergic neurons in the brain and the presence of Lewy bodies (LB) within the remaining affected neurons, comprised of α-synuclein protein ...
Biophysical analysis of SECIS binding protein 2 (SBP2) from Naegleria gruberi [0.03%]
纳格利雅原虫SECIS结合蛋白2(SBP2)的生物物理分析
Jéssica Fernandes Scortecci,Adriano de Freitas Fernandes,Vitor Hugo Balasco Serrão et al.
Jéssica Fernandes Scortecci et al.
The Selenocysteine (Sec - U) biosynthesis pathway is present in eukaryotes and prokaryotes, in which its incorporation is directed by the stop codon UGA and the structural mRNA element named Sec Insertion Sequence (SECIS) that contain an es...
Structural, functional relevance of DNAJBs in protein aggregation and associated neurodegenerative diseases [0.03%]
DNAJ家族成员在蛋白质聚集及其相关神经退行性疾病中的结构和功能作用
Siraj Fatima,Priyanka Pandey,Sandeep K Sharma et al.
Siraj Fatima et al.
DNAJ proteins, also known as HSP40s, are co-chaperones that regulate the multifunctionality of HSP70s in maintaining cellular protein homeostasis. The heterogeneous family of DNAJ co-chaperones is classified into three classes (A, B and C),...
Role of electrostatics in cold adaptation: A comparative study of eury- and stenopsychrophilic triose phosphate isomerase [0.03%]
静电作用在冷适应中的作用：全耐寒性和窄耐寒性甘油磷酸激酶的比较研究
Jan S Nowak,Sune Olesen,Pengfei Tian et al.
Jan S Nowak et al.
Psychrophilic (cold-active) organisms have developed enzymes that facilitate sufficient metabolic activity at low temperatures to sustain life. This occurs through molecular adaptations that tend to increase protein flexibility at the expen...
Exploring human carboxylesterases 1 and 2 selectivity of two families of substrates at an atomistic level [0.03%]
从原子水平上探讨人类羧酸酯酶1和2两类底物的选择性
Sergio R Ribone,Dario A Estrin,Mario A Quevedo
Sergio R Ribone
Human carboxylesterases (CES) are enzymes that play an important role in the metabolism and biotransformation of diverse substances. The two more relevant isoforms, CES1A1 and CES2A1, catalyze the hydrolysis of numerous approved drugs and p...
TMB Stab-pred: Predicting the stability of transmembrane β-barrel proteins using their sequence and structural signatures [0.03%]
基于序列和结构特征预测跨膜β barrels蛋白的稳定性
P Ramakrishna Reddy,A Kulandaisamy,M Michael Gromiha
P Ramakrishna Reddy
Understanding the folding and stability of transmembrane β-barrel proteins (TMBs) provides insights into their structural integrity, functional mechanisms, and implications for disease states. In this work, we have characterized the import...
Green tea polyphenol EGCG acts differentially on end-stage amyloid polymorphs of α-synuclein formed in different polyol osmolytes [0.03%]
绿色茶叶多酚EGCG对在不同多元醇渗透剂中形成的α-突触核蛋白终末期淀粉样聚集体的作用存在差异
Santosh Devi,Dushyant K Garg,Rajiv Bhat
Santosh Devi
Synucleinopathies are heterogenous group of disorders characterized by α-synuclein amyloid aggregates in the nervous system. Different synucleinopathy clinical subtypes are encoded by structurally diverse α-synuclein amyloid polymorphs re...
Crystal structure of thymidine kinase from the multi-drug resistant col strain of Staphylococcus aureus [0.03%]
多重耐药的社区 acquired MRSA菌株的脱氧胸苷激酶的晶体结构
Anam Ashraf,Ravi Kant Pal,Md Imtaiyaz Hassan
Anam Ashraf
Thymidine kinase (TK) is a key enzyme in the salvage pathway of thymidine that produces thymidine monophosphate. TK enzyme activity is tightly coupled to the cell cycle, exhibiting marked fluctuations in expression and activity. We report t...
Synovial fluid glycoproteome profiling in knee osteoarthritis: Molecular insights into type 2 diabetes-associated biomarkers and therapeutic targets [0.03%]
膝骨关节炎的滑液糖蛋白组分析：2型糖尿病相关生物标志物和治疗靶点的分子机制研究
Monidipa Konar,Bhavneet Kaur,Uttam Chand Saini et al.
Monidipa Konar et al.
Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) share common risk factors like age, obesity and hypertension. Currently, 52 % of diabetic patients suffer from arthritis. Diabetes facilitates osteoarthritis by altering lipid metaboli...