Methionine gamma lyase: Structure-activity relationships and therapeutic applications [0.03%]
甲硫氨酸γ裂解酶：结构活性关系和治疗应用
Samanta Raboni,Serena Faggiano,Stefano Bettati et al.
Samanta Raboni et al.
Methionine gamma lyase (MGL) is a bacterial and plant enzyme that catalyzes the conversion of methionine in methanthiol, 2-oxobutanoate and ammonia. The enzyme belongs to fold type I of the pyridoxal 5'-dependent family. The catalytic mecha...
PDZome-wide and structural characterization of the PDZ-binding motif of VANGL2 [0.03%]
VANGL2的PDZ结合基序的广泛和结构特征分析
Marta Montserrat-Gomez,Gergo Gogl,Kendall Carrasco et al.
Marta Montserrat-Gomez et al.
VANGL2 is a core component of the non-canonical Wnt/Planar Cell Polarity signaling pathway that uses its highly conserved carboxy-terminal type 1 PDZ-binding motif (PBM) to bind a variety of PDZ proteins. In this study, we characterize and ...
Propagation of conformational instability in FK506-binding protein FKBP12 [0.03%]
FK506结合蛋白FKBP12中构象不稳定性传播机制研究
David M LeMaster,Qamar Bashir,Griselda Hernández
David M LeMaster
FKBP12 is the archetype of the FK506 binding domains that define the family of FKBP proteins which participate in the regulation of various distinct physiological signaling processes. As the drugs FK506 and rapamycin inhibit many of these F...
BthTX-I, a phospholipase A2-like toxin, is inhibited by the plant cinnamic acid derivative: chlorogenic acid [0.03%]
BthTX-I，一种磷脂酶A2样毒素，被植物香豆酸衍生物：绿原酸抑制
Fábio Florença Cardoso,Guilherme Henrique Marchi Salvador,Walter Luís Garrido Cavalcante et al.
Fábio Florença Cardoso et al.
Snakebite is a significant health concern in tropical and subtropical regions, particularly in Africa, Asia, and Latin America, resulting in more than 2.7 million envenomations and an estimated one hundred thousand fatalities annually. The ...
Classification of binding property of amyloid β to lipid membranes: Membranomic research using quartz crystal microbalance combined with the immobilization of lipid planar membranes [0.03%]
淀粉样β与脂质膜结合性质的分类：使用石英晶体微天平结合固定脂质平面膜的膜组学研究
Toshinori Shimanouchi,Miki Iwamura,Yasuhiro Sano et al.
Toshinori Shimanouchi et al.
A biomembrane-related fibrillogenesis of Amyloid β from Alzheimer' disease (Aβ) is closely related to its accumulation behavior. A binding property of Aβ peptides from Alzheimer' disease to lipid membranes was then classified by a quartz...
FunPredCATH: An ensemble method for predicting protein function using CATH [0.03%]
FunPredCATH：一种使用CATH预测蛋白质功能的集成方法
Joseph Bonello,Christine Orengo
Joseph Bonello
Motivation: The growth of unannotated proteins in UniProt increases at a very high rate every year due to more efficient sequencing methods. However, the experimental annotation of proteins is a lengthy and expensive proc...
Kinetic characterization of the N-terminal domain of Malonyl-CoA reductase [0.03%]
丙二酰辅酶A还原酶N端结构域的动力学特征分析
Mirela Tkalcic Cavuzic,Grover L Waldrop
Mirela Tkalcic Cavuzic
Climate change is driving a search for environmentally safe methods to produce chemicals used in ordinary life. One such molecule is 3-hydroxypropionic acid, which is a platform industrial chemical used as a precursor for a variety of other...
Structural basis of nuclear transport for NEIL DNA glycosylases mediated by importin-alpha [0.03%]
NEIL DNA碱基切除修复酶的核输入受体为进口蛋白-α：结构基础研究
Ivan R Moraes,Hamine C de Oliveira,Marcos R M Fontes
Ivan R Moraes
NEIL glycosylases, including NEIL1, NEIL2, and NEIL3, play a crucial role in the base excision DNA repair pathway (BER). The classical importin pathway mediated by importin α/β and cargo proteins containing nuclear localization sequences ...
Crystal structure and interconversion of monomers and domain-swapped dimers of the walnut tree phytocystatin [0.03%]
核桃植物胱抑素单体与交换域二聚体的晶体结构及相互转换关系研究
Gisele Alvarenga Simpson,Isabela Fernandes Rezende,Alencar da Silva Peixoto et al.
Gisele Alvarenga Simpson et al.
Biotechnological applications of phytocystatins have garnered significant interest due to their potential applications in crop protection and improve crop resistance to abiotic stress factors. Cof1 and Wal1 are phytocystatins derived from C...
Paradoxical effects on ice nucleation are intrinsic to a small winter flounder antifreeze protein [0.03%]
微小的冬拟鱼防冻蛋白对冰核化产生悖论效应是一个内在属性
Xing Jian Chang,Dane C Sands,Kathryn Vanya Ewart
Xing Jian Chang
Antifreeze proteins (AFPs) bind to ice in solutions, resulting in non-colligative freezing point depression; however, their effects on ice nucleation are not well understood. The predominant plasma AFP of winter flounder (Pseudopleuronectes...