Exploring human carboxylesterases 1 and 2 selectivity of two families of substrates at an atomistic level
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Human carboxylesterases (CES) are enzymes that play an important role in the metabolism and biotransformation of diverse substances. The two more relevant isoforms, CES1A1 and CES2A1, catalyze the hydrolysis of numerous approved drugs and prodrugs. The elucida... ...
