Cristel V Camacho,Chenqian Liu,W Lee Kraus
Cristel V Camacho
ADP-ribosylation (ADPRylation) is a post-translational modification best known for its roles in DNA damage responses and cytoplasmic signaling, but it also serves important functions in epigenome regulation. In the nucleus, ADPRylation modu...
Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas [0.03%]
生长抑素受体4(SSTR4)在皮肤和头颈部鳞状细胞癌中的肿瘤抑制作用
Ali Taqvi,Tuan Khang Huynh,Adway Kadam et al.
Ali Taqvi et al.
The mutational landscape of head & neck and cutaneous squamous cell carcinomas (HNSCC, cSCC) has major gene alterations involving PIK3CA, NOTCH1, and TP53 among others that contribute to tumorigenesis. In this study, we focused on somatosta...
RETRACTION: LncRNA AATBC Regulates Pinin to Promote Metastasis in Nasopharyngeal Carcinoma [0.03%]
撤稿：长链非编码RNA AATBC通过调节Pinin促进鼻咽癌转移
T. Tang, L. Yang, Y. Cao, M. Wang, S. Zhang, Z. Gong, F. Xiong, Y. He, Y. Zhou, Q. Liao, B. Xiang, M. Zhou, C. Guo, X. Li, Y. Li, W. Xiong, G. Li, and Z. Zeng, "LncRNA AATBC Regulates Pinin to Promote Metastasis in Nasopharyngeal Carcinoma,...
Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer [0.03%]
唾液腺癌转移的异质性和克隆演化的一项尸检研究
Gerben Lassche,Niels J van Ruitenbeek,Charlotte Adang et al.
Gerben Lassche et al.
Genetic tumour heterogeneity, driven by clonal evolution, contributes to therapy resistance in many cancers. Most salivary gland cancers, including adenoid cystic carcinoma (AdCC) and myoepithelial carcinoma (MECA), lack effective systemic ...
Cancer cell-intrinsic type 1 interferon: production, signaling, and outcomes within sex-biased, female malignancies [0.03%]
癌症细胞固有的I型干扰素：在性别偏向的女性恶性肿瘤中的产生、信号传导和结果
Ashlyn Conant,Nora Badiner,Sharon Asariah et al.
Ashlyn Conant et al.
Type 1 interferons (IFN-1), such as IFN-α and IFN-β, are the most well-studied interferon class due to their abundant expression, widespread signaling, and potent immunomodulatory functions. Although the role of these cytokines in mediati...
Rohit Thalla,Jyoti Lamichhane,Cameron Lewis et al.
Rohit Thalla et al.
Myelodysplastic syndromes (MDS) are a heterogeneous group of pre-leukemic diseases marked by ineffective bone marrow (BM) hematopoiesis, peripheral cytopenia, morphologic dysplasia, and an increased risk of leukemic transformation. Increase...
Eva Crespo-García,Manel Esteller
Eva Crespo-García
Cancer develops inside organized tissue environments wherein cellular behavior is heavily influenced by local interactions and spatially restricted regulatory programs. While bulk and single-cell sequencing technologies have fundamentally r...
Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease [0.03%]
家犬恶病质和癌症的循环微小核糖核酸标志物作为人类疾病的比较医学模型
Soon-Seok Park,Kyongman An,Gyeonghwa Kim et al.
Soon-Seok Park et al.
Cachexia, a severe muscle-wasting syndrome, lacks objective biomarkers for early detection. This study aimed to identify circulating microRNA signatures for cachexia and cancer in senior dogs, a comparative oncology model for human disease....
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer [0.03%]
表观遗传药物联合雌激素治疗增强ER阳性乳腺癌疗效
Anneka L Johnson Thomas,Barbara Karakyriakou,Patricia C Muskus et al.
Anneka L Johnson Thomas et al.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine-resistant estrogen receptor (ER)-positive breast cancer, but its mechanism of action and strategies to increase efficacy remain unclear. Estrogen therapy can indu...