Interpreting the effects of DNA polymerase variants at the structural level [0.03%]
从结构角度解读DNA聚合酶变异体的作用机制
Matteo Arnaudi,Karolina Krzesińska,Ludovica Beltrame et al.
Matteo Arnaudi et al.
Genetic variants in the DNA polymerase enzymes POLE and POLD1 can affect protein function by altering stability, catalysis, DNA binding, and interactions with other biomolecules. Understanding the structural basis of these variants is impor...
ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma-cfDNA of advanced breast cancer patients: A feasibility proof-of-concept study [0.03%]
循环肿瘤细胞(CTC)及其配对血浆游离DNA(ctDNA)中雌激素受体α基因甲基化和突变状态检测的可行性概念验证研究
Dimitra Stergiopoulou,Athina Markou,Eleonora Nicolo et al.
Dimitra Stergiopoulou et al.
Endocrine resistance is a complex phenomenon, including alterations of the ESR1 gene. The aim of this study was to simultaneously analyze ESR1 promoter methylation and ESR1 hotspot mutations in circulating tumor cells (CTCs) and paired plas...
Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma [0.03%]
发育程序驱动肺腺癌的细胞可塑性、疾病进展和治疗抵抗
Kamila J Bienkowska,Stephany Gallardo,Nur S Zainal et al.
Kamila J Bienkowska et al.
Cellular plasticity is central to non-small cell lung cancer (NSCLC) disease progression and linked to aberrant regulation of developmental programmes. Here, we investigated the contribution of two developmental programmes, alveogenesis (AL...
A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose-driven glioblastoma [0.03%]
一种新型喹唑酮胰岛素受体抑制剂及其与EGFR抑制剂在葡萄糖驱动的胶质母细胞瘤中的协同作用
Patryk Rurka,Wioleta Cieślik,Wojciech Płaziński et al.
Patryk Rurka et al.
Aberrant signaling through insulin-like growth factor 1 receptor (IGF1R) and epidermal growth factor receptor (EGFR) drives glioblastoma (GBM) progression and therapy resistance. Herein, we describe the synthesis and biological evaluation o...
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization [0.03%]
致癌基因DMTF1β通过ULK1稳定调节自噬促进癌细胞运动性
Jun Xu,Nicolas J Niklaus,Anna M Schläfli et al.
Jun Xu et al.
The cyclin D binding Myb-like Transcription Factor 1 (DMTF1) is a haploinsufficient tumor suppressor in various tumors. Alternative splicing generates a dominant negative, truncated version of full-length DMTF1α, named DMTF1β. DMTF1β has...
Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr-mutated lung cancer [0.03%]
干扰素基因刺激剂增强Osimertinib治疗EGFR突变型肺癌的抗肿瘤免疫作用
Jun Nishimura,Tadahiro Kuribayashi,Johannes Brägelmann et al.
Jun Nishimura et al.
Epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancers (NSCLCs) lack effective immunotherapy due to a noninflamed tumor microenvironment (TME). We previously reported that EGFR tyrosine-kinase-inhibitor (TKI) induced CD8...
Correction to "Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors" [0.03%]
关于“米非司酮增加mRNA翻译速率、触发未折叠蛋白反应、增加自噬流量并与蛋白酶体或溶酶体抑制剂联合杀伤卵巢癌细胞”的勘误注释
Published Erratum
Molecular oncology. 2026 May 19. DOI:10.1002/1878-0261.70270 2026
Heterozygous loss-of-function alleles associate the conserved 3'-5' exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5-fluorouracil [0.03%]
异基因功能丧失型等位基因将保守的3'-5'外核糖核酸酶EXOSC10与抗癌药物5-氟尿嘧啶高敏感性相关联
Radhika Sain,Yann Le Page,Frédéric Percevault et al.
Radhika Sain et al.
The 3'-5' exoribonuclease EXOSC10 degrades aberrant mRNAs and noncoding RNAs in cooperation with the nuclear RNA exosome. EXOSC10's localization and stability are regulated by sumoylation and proteasomal degradation in response to stress, a...
USP29-regulated noncanonical stabilization of the hypoxia-inducible factor-α in aggressive prostate cancer [0.03%]
USP29介导的低氧诱导因子非经典稳定化在前列腺癌进展中的作用
Amelie S Schober,Leire Moreno-Cugnon,Laura Martínez-Pérez et al.
Amelie S Schober et al.
Oxygen availability is frequently compromised in solid tumours, making intratumoural hypoxia a common feature of cancer. In prostate cancer (PCa), hypoxia is strongly associated with aggressive disease and poor prognosis. Hypoxia-inducible ...
Loss of IGF-1R impairs DNA-PKcs recruitment to chromatin leading to defective end-joining [0.03%]
IGF-1R丢失导致DNA-PKcs不能招募到染色质中从而造成末端连接缺陷
Matthew O Ellis,Jack V Mills,Wojciech Niedzwiedz et al.
Matthew O Ellis et al.
The insulin-like growth factor (IGF) axis regulates cancer cell proliferation, growth, invasion, and therapy resistance. Elevated expression of the type 1 IGF receptor (IGF-1R) is linked to radioresistance and biochemical recurrence in pros...