Circulating succinate changes during acute cold exposure are not related with brown adipose tissue in humans [0.03%]
急性冷暴露下人体循环草酰乙酸的变化与棕色脂肪组织无关
Francisco J Osuna-Prieto,Borja Martinez-Tellez,Guillermo Sánchez-Delgado et al.
Francisco J Osuna-Prieto et al.
Brown adipose tissue (BAT) activity in humans is linked to better glucose metabolism and cardiometabolic health. In mice, cold exposure increases circulating succinate and enhances BAT thermogenesis, but whether similar succinate responses ...
Randomized Controlled Trial
Journal of physiology and biochemistry. 2026 Aug 1;82(1):76. DOI:10.1007/s13105-026-01212-z 2026
Dieckol suppresses lipid accumulation and promotes thermogenic markers in 3T3-L1 adipocytes via ERK/p38 MAPK signaling [0.03%]
狄克醇通过ERK/p38MAPK信号抑制3T3-L1脂肪细胞中的脂质积累并促进生热标志物的表达
Indyaswan T Suryaningtyas,Won-Kyo Jung,Jae-Young Je
Indyaswan T Suryaningtyas
Thermogenic programming of adipocytes represents a promising strategy to enhance energy expenditure; however, most pharmacological browning agents activate PPARγ, which simultaneously promotes lipid accumulation and adipocyte hypertrophy. ...
Garoa Santocildes,Karenia Lorenzo,José Magalhães et al.
Garoa Santocildes et al.
Acute exposure to high-altitude hypobaric hypoxia (HH) disrupts physiological homeostasis. While gastrointestinal and neurological disturbances are its main manifestations, muscle function is also affected. However, its short-term effects o...
Redox-regulated cell death in gastric cancer: Molecular insights and therapeutic opportunities [0.03%]
胃癌中的氧化还原调节细胞死亡：分子见解和治疗机会
He Qi,Chenbin Cao,Wenyan Li et al.
He Qi et al.
Oxidative stress, resulting from the disruption of redox homeostasis, is increasingly recognized as a central driver of gastric cancer pathogenesis and a critical determinant of cell fate. An imbalance between reactive oxygen species (ROS) ...
Stabilization of HSP70 by deubiquitinase OTUB1 attenuates sleep deprivation-induced cognitive impairment in mice [0.03%]
去泛素化酶OTUB1稳定HSP70以减轻睡眠剥夺引起的认知障碍
Changsheng Su,Guoshao Zhu,Zhenming Kang et al.
Changsheng Su et al.
This study aims to investigate the role of the deubiquitinase OTUB1 in regulating sleep deprivation-induced cognitive impairment in mice and to elucidate the underlying molecular pathways. A mouse model of sleep deprivation was established,...
Acute mitochondrial dysfunction impairs neuromuscular transmission and contractility in mouse diaphragm: the protective potential of 25-hydroxycholesterol [0.03%]
急性线粒体功能障碍损害小鼠膈肌的神经肌肉传递和收缩能力：25-羟基胆固醇的保护潜力
Eva A Kapliukhina,Nikita S Fedorov,Andrei N Tsentsevitsky et al.
Eva A Kapliukhina et al.
Mitochondrial impairment, accompanied by excessive reactive oxygen species (ROS) production, is a key contributor to muscle atrophy and neuromuscular disorders, leading to locomotor and respiratory failure. Antimycin A (AA), an inhibitor of...
Targeting canonical TGFβ/SMAD3 and ERK1/2 signaling in human valve interstitial cells to modulate immune-fibrotic responses in rheumatic heart disease [0.03%]
针对风湿性心脏病瓣膜间质细胞的TGFβ / SMAD3和ERK1 / 2信号传导以调节免疫纤维反应
Charan Sai Ramireddi,Mohit K Rai,Anjali Singh et al.
Charan Sai Ramireddi et al.
Rheumatic heart disease (RHD) is a chronic sequel of acute rheumatic fever characterized by sustained inflammation, fibrosis, and valve degeneration; however, the underlying processes remain unclear. To identify dysregulated molecular pathw...
Aryl hydrocarbon receptor deficiency leads to sex- and age-dependent colonic dysmotility in mice [0.03%]
芳香烃受体缺乏导致小鼠性别和年龄依赖性的结肠运动功能障碍
Alicia Valls,David Verdú,Sol Guerra-Ojeda et al.
Alicia Valls et al.
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in xenobiotic sensing and multiple physiological functions, including intestinal homeostasis. Aging is associated with reduced colonic motility and cons...
Amir Ajoolabady,Altaf A Abdulkhaliq,Johra Khan et al.
Amir Ajoolabady et al.
Pyroptosis is a lytic form of cell death that is highly regulated and executed by certain members of the Gasdermin protein family. The lytic process occurs because the N-terminal domains of gasdermins possess pore-forming capabilities, ther...
Effectiveness of dietary modifications in reversing damage induced by high-fat diet in rats [0.03%]
饮食干预逆转高脂膳食诱导大鼠肠道损伤的效果研究
Manuel Jiménez-García,Maria Magdalena Quetglas-Llabrés,Susana Esteban-Valdés et al.
Manuel Jiménez-García et al.
Excessive dietary fat intake is a major health concern, contributing to the increasing prevalence of Metabolic Dysfunction Associated with Fatty Liver Disease (MAFLD) worldwide; different prevalence between sexes has been postulated but it ...