Shu Zhong,Jingjing Tong
Shu Zhong
Immunotherapy is a promising and long-lasting tumor treatment method, but it is challenged by the complex metabolism of tumors. To optimize immunotherapy, it is essential to further investigate the key proteins that regulate tumor metabolis...
Illuminating ligand-induced dynamics in nuclear receptors through MD simulations [0.03%]
通过分子动力学模拟揭示配体诱导的核受体动态行为
Tracy Yu,Nishanti Sudhakar,C Denise Okafor
Tracy Yu
Nuclear receptors (NRs) regulate gene expression in critical physiological processes, with their functionality finely tuned by ligand-induced conformational changes. While NRs may sometimes undergo significant conformational motions in resp...
Alexander Gillis,Scott Berry
Alexander Gillis
RNA polymerase II (Pol II) is the multi-protein complex responsible for transcribing all protein-coding messenger RNA (mRNA). Most research on gene regulation is focused on the mechanisms controlling which genes are transcribed when, or on ...
Transcriptional landscape of long non-coding RNAs (lncRNAs) and its implication in viral diseases [0.03%]
长非编码RNA（lncRNA）的转录图谱及其在病毒感染中的作用
Ankita Rai,Tannu Bhagchandani,Ravi Tandon
Ankita Rai
Long non-coding RNAs (lncRNAs) are RNA transcripts of size >200 bp that do not translate into proteins. Emerging data revealed that viral infection results in systemic changes in the host at transcriptional level. These include alterations ...
MicroRNA-mediated regulation of nonsense-mediated mRNA decay factors: Insights into microRNA prediction tools and profiling techniques [0.03%]
微小RNA介导的无义介导的mRNA衰败因子调控：关于微小RNA预测工具和分析技术的启示
Priyanka Yadav,Raja Tamilselvan,Harita Mani et al.
Priyanka Yadav et al.
Nonsense-mediated mRNA decay (NMD) stands out as a prominent RNA surveillance mechanism within eukaryotes, meticulously overseeing both RNA abundance and integrity by eliminating aberrant transcripts. These defective transcripts are discern...
Histone H3K4ac, as a marker of active transcription start sites and enhancers, plays roles in histone eviction and RNA transcription [0.03%]
组蛋白H3K4乙酰化作为一种转录起始位点和增强子的标志在组蛋白去除和RNA转录中发挥作用
Jin Kang,Yujin Kang,AeRi Kim
Jin Kang
The lysine 4 of histone H3 (H3K4) can be methylated or acetylated into four states: H3K4me1, H3K4me2, H3K4me3, or H3K4ac. Unlike H3K4 methylation, the genome-wide distribution and functional roles of H3K4ac remain unclear. To understand the...
LncRNA-mediated orchestrations of alternative splicing in the landscape of breast cancer [0.03%]
长链非编码RNA介导的乳腺癌可变剪接调控景观中的协调作用
Samarth Kansara,Prajwali Sawant,Taranjeet Kaur et al.
Samarth Kansara et al.
Alternative splicing (AS) is a fundamental post-transcriptional process in eukaryotes, enabling a single gene to generate diverse mRNA transcripts, thereby enhancing protein variability. This process involves the excision of introns and the...
An epitope-tagged Swd2 reveals the different requirements of Swd2 concentration in H3K4 methylation and viability [0.03%]
具表位标记的Swd2揭示了H3K4甲基化和存活所需的不同浓度的Swd2
Junsoo Oh,Seho Kim,SangMyung Kim et al.
Junsoo Oh et al.
Swd2/Cps35 is a common component of the COMPASS H3K4 methyltransferase and CPF transcription termination complex in Saccharomyces cerevisiae. The deletion of SWD2 is lethal, which results from transcription termination defects in snoRNA gen...
Histone H2B ubiquitylation: Connections to transcription and effects on chromatin structure [0.03%]
组蛋白H2B泛素化：与转录的联系及其对染色质结构的影响
Tasniem Fetian,Aakash Grover,Karen M Arndt
Tasniem Fetian
Nucleosomes are major determinants of eukaryotic genome organization and regulation. Many studies, incorporating a diversity of experimental approaches, have been focused on identifying and discerning the contributions of histone post-trans...
José E Pérez-Ortín,María J García-Marcelo,Irene Delgado-Román et al.
José E Pérez-Ortín et al.
Cells vary in volume throughout their life cycle and in many other circumstances, while their genome remains identical. Hence, the RNA production factory must adapt to changing needs, while maintaining the same production lines. This parado...