NMN alleviates oxidative stress damage in alopecia areata by activating SIRT7 and promoting glutamine metabolism [0.03%]
NMN通过激活SIRT7和促进谷氨酰胺代谢来缓解斑秃氧化应激损伤
Tianyu Cao,Lan Jiang,Lin Liu et al.
Tianyu Cao et al.
Alopecia areata (AA) is an autoimmune disorder characterized by oxidative stress-induced dysfunction of hair follicle stem cells (HFSCs). Nicotinamide mononucleotide (NMN), a precursor of NAD+, exhibits antioxidant properties, but its role ...
Exercise as an epigenetic modifier of cancer-associated inflammation: Unraveling the DNA methylation, histone modification, and non-coding RNA circuitry [0.03%]
运动通过表观遗传学调节癌症相关炎症：揭示DNA甲基化、组蛋白修饰和非编码RNA的调控电路
Wenhui Tan,Bing Wang,Xiumei Tian et al.
Wenhui Tan et al.
Chronic inflammation is a hallmark of cancer, driving initiation, progression, and metastasis through sustained pro-inflammatory signaling and immune microenvironment remodeling. Physical exercise reduces systemic low-grade inflammation and...
microRNA-203a-3p sensitizes cisplatin through disruption of RAN-dependent RRM2 nuclear localization and mitochondrial stress readouts [0.03%]
microRNA-203a-3p通过破坏RAN依赖的RRM2核定位和线粒体压力读数对顺铂产生敏感化效应
Priyajit Biswal,Sruti Biswal,Bipasha Behura et al.
Priyajit Biswal et al.
The efficacy of chemotherapeutic drugs is often limited by cancer cells' adaptive pro-survival mechanisms that attenuate treatment response. Here, we observed marked downregulation of miR-203a-3p in OSCC cells upon exposure to cisplatin, wh...
METTL3 mediates Ang-II-induced cardiac hypertrophy by regulating KLF5 expression in an m6A-dependent manner [0.03%]
METTL3通过m6A依赖的方式介导Ang-II诱导的心脏肥大并调节KLF5表达
Chao Cai,Yan Jiang,Yiyan Wang et al.
Chao Cai et al.
Background: Cardiac hypertrophy is a pivotal pathological process leading to heart failure, driven by chronic stress, pressure overload, and neurohormonal stimulation, such as Angiotensin II (Ang II). Although METTL3-medi...
The vitamin rheostat: A unified model of epigenetic feedback in vitamin homeostasis [0.03%]
维生素除霸仪：维生素稳态表观遗传反馈的统一模型
Ruslan Kubant,G Harvey Anderson,Mykhailo Korda
Ruslan Kubant
Recent evidence implicates epigenetic mechanisms in vitamin metabolism, yet most studies remain focused on individual vitamins. In this mini-review, we extend beyond single-vitamin paradigms to propose the Vitamin Rheostat: a unifying model...
Short-lived versus long-lived lncRNAs: RNA stability as a determinant of regulatory function [0.03%]
短寿命与长寿命的lncRNA：RNA稳定性作为一种调控功能决定因素
Hidenori Tani
Hidenori Tani
Long non-coding RNAs (lncRNAs) are classified by sequence, genomic context, and subcellular localization, yet RNA stability remains an underexplored axis of functional classification. Genome-wide profiling by BRIC-seq identified hundreds of...
Circular RNAs in animals: Biogenesis, function and cell fate control [0.03%]
动物中的环形RNA：生物发生、功能与细胞命运决定
Rita Mohammad,Yelena Parfyonova,Iurii Stafeev
Rita Mohammad
In recent years, circular RNAs (circRNAs), a class of RNA molecules characterized by a covalently closed circular structure, have emerged as a complex family of eukaryotic transcripts with distinctive biological features. Beyond their unusu...
Small RNA-mediated regulation of stress tolerance in Deinococcus radiodurans [0.03%]
苏云金芽孢杆菌中小RNA对辐射耐受性的调控作用研究
Shiv Narayan Rai,Krishan Kumar
Shiv Narayan Rai
Deinococcus radiodurans exhibits exceptional resilience to extreme stressors like ionizing radiation, oxidative damage, and desiccation. This extraordinary resistance stems from a sophisticated regulatory network that enables survival in en...
Proteomic analysis reveals distinct gene regulatory functions of the paralogs MAGOH and MAGOHB in cell proliferation [0.03%]
蛋白质组分析揭示同源异形基因MAGOHB在细胞增殖中的独特基因调控功能
Ayushi Rehman,Raja Tamilselvan,Priyanka Yadav et al.
Ayushi Rehman et al.
The MAGOH and MAGOHB paralogs are core components of the Exon Junction Complex (EJC). Previous studies have established that their simultaneous depletion is lethal, underscoring their essentiality. However, their potential redundancy and in...
Nuclear export block of tyrosine-phosphorylated STAT1 facilitates rapid responsiveness to interferon-γ stimuli at the expense of signal strength [0.03%]
酪氨酸磷酸化STAT1的核输出抑制促进干扰素-γ刺激的快速反应，但以信号强度为代价
Thomas Meyer,Florian Lamprecht,Andreas Begitt et al.
Thomas Meyer et al.
Interferon-induced STAT1 (signal transducer and activator of transcription 1) signal transduction constitutes a dynamic network of concurrent activation and inactivation steps that directly transmits extracellular information from the plasm...