Circular RNAs in animals: Biogenesis, function and cell fate control [0.03%]
动物中的环形RNA：生物发生、功能与细胞命运决定
Rita Mohammad,Yelena Parfyonova,Iurii Stafeev
Rita Mohammad
In recent years, circular RNAs (circRNAs), a class of RNA molecules characterized by a covalently closed circular structure, have emerged as a complex family of eukaryotic transcripts with distinctive biological features. Beyond their unusu...
Small RNA-mediated regulation of stress tolerance in Deinococcus radiodurans [0.03%]
苏云金芽孢杆菌中小RNA对辐射耐受性的调控作用研究
Shiv Narayan Rai,Krishan Kumar
Shiv Narayan Rai
Deinococcus radiodurans exhibits exceptional resilience to extreme stressors like ionizing radiation, oxidative damage, and desiccation. This extraordinary resistance stems from a sophisticated regulatory network that enables survival in en...
Proteomic analysis reveals distinct gene regulatory functions of the paralogs MAGOH and MAGOHB in cell proliferation [0.03%]
蛋白质组分析揭示同源异形基因MAGOHB在细胞增殖中的独特基因调控功能
Ayushi Rehman,Raja Tamilselvan,Priyanka Yadav et al.
Ayushi Rehman et al.
The MAGOH and MAGOHB paralogs are core components of the Exon Junction Complex (EJC). Previous studies have established that their simultaneous depletion is lethal, underscoring their essentiality. However, their potential redundancy and in...
Nuclear export block of tyrosine-phosphorylated STAT1 facilitates rapid responsiveness to interferon-γ stimuli at the expense of signal strength [0.03%]
酪氨酸磷酸化STAT1的核输出抑制促进干扰素-γ刺激的快速反应，但以信号强度为代价
Thomas Meyer,Florian Lamprecht,Andreas Begitt et al.
Thomas Meyer et al.
Interferon-induced STAT1 (signal transducer and activator of transcription 1) signal transduction constitutes a dynamic network of concurrent activation and inactivation steps that directly transmits extracellular information from the plasm...
Transcription coactivator SAYP cooperates with transcription factor DEAF1 to mediate immune defense in Drosophila melanogaster [0.03%]
转录共激活因子SAYP通过与转录因子DEAF1合作介导果蝇的免疫防御反应
Mona Ghassah,Yulia Ulianova,Konstantin I Balagurov et al.
Mona Ghassah et al.
Innate immunity is a multilevel system, where each stage plays a key role in ensuring effective immune defense. At the level of chromatin, transcription factors and coactivator protein complexes play a significant role in regulating the imm...
Musaed Hamood Al-Subari,Yugang Xiao,Qubo Zhu
Musaed Hamood Al-Subari
RNA helicases are fundamental ATP-dependent enzymes that remodel RNA structures and ribonucleoprotein complexes. Recent studies reveal that RNA helicases are critical regulators of circular RNA networks, where circRNAs function as stable re...
Gill methylome and transcriptome patterns in the context of freshwater intolerance in European sea bass [0.03%]
欧洲海鲈在淡水不耐受情况下的甲基化和转录模式研究
Eva Blondeau-Bidet,Céline Cosseau,Thibaut L&#x;Honoré et al.
Eva Blondeau-Bidet et al.
Epigenetic marks induced by the environment play a key role in phenotypic plasticity and stress tolerance. We examined phenotypic responses in European sea bass D. labrax following a two-week exposure to fresh water (FW). FW transfer result...
In Cereibacter sphaeroides, expression of flagellin FlaA is posttranscriptionally controlled by the 5' untranslated region of its mRNA and the regulatory proteins FlaF, FlbT and FlbR [0.03%]
Cereibacter sphaeroides 中的鞭毛蛋白FlaA由其mRNA的5'-UTR和调控蛋白FlaF、FlbT和FlbR翻译后控制表达
Julia M Benítez,Benjamín Vega-Baray,Manuel González-Vera et al.
Julia M Benítez et al.
In bacteria, flagellar filaments consist of thousands of flagellin subunits, making their assembly energetically costly. Flagellin synthesis is tightly regulated and in alpha-proteobacteria, this is achieved through a posttranscriptional me...
Advancing crop resilience to environmental stresses: Insights from epigenetic modification and CRISPR/dCas9-based editing [0.03%]
作物环境压力抗逆性的提升——表观修饰和CRISPR/dCas9编辑研究进展
Melvin Prasad,Radhakrishna Shetty
Melvin Prasad
Plants are immobile organisms, constantly exposed to a wide variety of environmental challenges, among these, drought, salinity and extreme temperatures are the most detrimental factors that significantly affect growth and productivity, lea...
Alternative splicing of Mov10 regulates mesangial cell proliferation in diabetic kidney disease [0.03%]
备选剪接的Mov10通过调节糖尿病肾病中系膜细胞增殖发挥功能
Qijia Wang,Xinyu Chong,Handeng Liu et al.
Qijia Wang et al.
Background: Diabetic kidney disease (DKD) is a major microvascular complication of diabetes, characterized by abnormal mesangial cell (MC) proliferation, yet the underlying mechanisms remain unclear. ...