Machine learning based analysis of single-cell data reveals evidence of subject-specific single-cell gene expression profiles in acute myeloid leukaemia patients and healthy controls [0.03%]
基于机器学习的单细胞数据分析揭示了急性髓系白血病患者和健康对照中以个体为单位的单细胞基因表达谱特征
Andreas Chrysostomou,Cristina Furlan,Edoardo Saccenti
Andreas Chrysostomou
Acute Myeloid Leukaemia (AML) is characterized by uncontrolled growth of immature myeloid cells, disrupting normal blood production. Treatment typically involves chemotherapy, targeted therapy, and stem cell transplantation but many patient...
Long noncoding RNAs in ubiquitination, protein degradation, and human diseases [0.03%]
泛素化、蛋白质降解和人类疾病中的长链非编码RNA
Prarthana Guha,Avisankar Chini,Ashcharya Rishi et al.
Prarthana Guha et al.
Protein stability and turnover is critical in normal cellular and physiological process and their misregulation may contribute to accumulation of unwanted proteins causing cellular malfunction, neurodegeneration, mitochondrial malfunction, ...
Guoqiang Xu,Yu-Sheng Cong,Sudipto Das
Guoqiang Xu
Uncovering the functions and mechanisms of regulatory elements-associated non-coding RNAs [0.03%]
揭示调控元件关联的非编码RNA的功能与机制
Olivier Fosseprez,Olivier Cuvier
Olivier Fosseprez
Over the past decade, regulatory non-coding RNAs (ncRNAs) produced by RNA Pol II have been revealed as meaningful players in various essential cellular functions. In particular, thousands of ncRNAs are produced at transcriptional regulatory...
Normalization of gene counts affects principal components-based exploratory analysis of RNA-sequencing data [0.03%]
归一化影响基于RNA测序数据的主成分分析结果
Henk J van Lingen,Maria Suarez-Diez,Edoardo Saccenti
Henk J van Lingen
Normalization of gene expression count data is an essential step of in the analysis of RNA-sequencing data. Its statistical analysis has been mostly addressed in the context of differential expression analysis, that is in the univariate set...
Crosstalk between circular RNAs and the STAT3 signaling pathway in human cancer [0.03%]
circRNA与STAT3信号通路在人类肿瘤中的互作关系研究进展
Mansour Almouh,Chadi Soukkarieh,Morshed Kassouha et al.
Mansour Almouh et al.
Circular RNAs (circRNAs) are endogenous covalently closed single-stranded RNAs produced by reverse splicing of pre-mRNA. Emerging evidence suggests that circRNAs contribute to cancer progression by modulating the oncogenic STAT3 signaling p...
Human ARMC6 binds in vitro to both cancer genes and telomeric RNA, favoring G-quadruplex structure recognition [0.03%]
人类ARMC6在体外与癌基因和端粒RNA结合，有利于G-四链结构识别
Matej Adámik,Zuzana Soldánová,Magdaléna Drotárová et al.
Matej Adámik et al.
Armadillo repeat-containing proteins (ARMCs) are a large family found throughout eukaryotes, which play prominent roles in cell adhesion, signaling and cytoskeletal regulation. The ARMC6 protein is highly conserved in primates, including hu...
E M Stasevich,A V Simonova,E A Bogomolova et al.
E M Stasevich et al.
A certain degree of chromatin openness is necessary for the activity of transcription-regulating regions within the genome, facilitating accessibility to RNA polymerases and subsequent synthesis of regulatory element RNAs (regRNAs) from the...
H3K56 acetylation affects Candida albicans morphology and secreted soluble factors interacting with the host [0.03%]
组蛋白乙酰化H3K56影响白色念珠菌形态和与宿主相互作用的分泌型可溶因子
Marisa Conte,Daniela Eletto,Martina Pannetta et al.
Marisa Conte et al.
In recent years, epigenetics has been revealed as a mechanism able to modulate the expression of virulence traits in diverse pathogens, including Candida albicans. Indeed, epigenetic regulation can sense environmental changes, leading to th...
Incautious design of shRNAs for stable overexpression of miRNAs could result in generation of undesired isomiRs [0.03%]
稳定过表达microRNA的shRNA的设计不当可能导致不必要的异质性成熟型microRNA的产生
Diana Maltseva,Ivan Kirillov,Anton Zhiyanov et al.
Diana Maltseva et al.
shRNA-mediated strategy of miRNA overexpression based on RNA Polymerase III (Pol III) expression cassettes is widely used for miRNA functional studies. For some miRNAs, e.g., encoded in the genome as a part of a polycistronic miRNA cluster,...