Heterogeneity of acute myeloid leukemia patients explored through single-cell and single-sample gene regulatory networks [0.03%]
通过单细胞和单样本基因调控网络探讨急性髓系白血病患者的异质性
Leandro Fernandes,Edoardo Saccenti
Leandro Fernandes
Acute myeloid leukaemia (AML) is a genetically heterogeneous disease, driven by diverse mutations and epigenetic alterations that disrupt normal haematopoiesis. Understanding how this heterogeneity manifests at the gene regulatory level can...
TET enzymes: Involvement in cancer development and therapeutical perspectives [0.03%]
TET酶：在癌症发生发展中的作用及治疗前景
Tarik Aanniz,Meriem El Fessikh,Jihane Touhtouh et al.
Tarik Aanniz et al.
The TET family of enzymes is essential for the dynamic regulation of DNA methylation and the epigenetic landscape of human genomes. Their ability to oxidize 5-methylcytosine (5mC) into various hydroxymethylated derivatives facilitates activ...
The cAMP receptor protein, SyCRP1 acts as a transcriptional repressor of CO2-concentrating mechanism genes at high inorganic carbon levels in Synechocystis PCC 6803 [0.03%]
cAMP受体蛋白SyCRP1在高无机碳浓度下作为蓝藻CO2浓缩机制基因的转录抑制因子发挥作用
Suraj Chauhan,N Prakash Prabhu,Martin Hagemann et al.
Suraj Chauhan et al.
Cyanobacteria utilize a CO2-concentrating mechanism (CCM) to enhance photosynthetic efficiency by accumulating CO2 around RuBisCO, a process crucial for adapting to fluctuating environmental CO2 levels. While the upregulation of CCM genes u...
Transcriptional activation of the PKLR gene by novel erythroid-specific regulatory elements [0.03%]
新型红细胞特异性调节子激活PKLR基因的转录
Yea Woon Kim,Jin Kang,AeRi Kim
Yea Woon Kim
The pyruvate kinase L/R (PKLR) gene encodes the L- and R-type isoforms of pyruvate kinase, which catalyze the final step of glycolysis in mammals. The L-type isozyme is mainly found in liver cells, whereas the R-type isozyme is produced spe...
RNA-protein interaction techniques - A historical and comparative analysis [0.03%]
RNA-蛋白质相互作用技术的历史及比较分析
Sourabh Chakrabarty,Sayan Roy,Soumyadip Sarkar et al.
Sourabh Chakrabarty et al.
RNAs intricately orchestrate a myriad of molecular and cellular processes. This includes mRNAs which serve as the essential blueprints for protein synthesis and the non-coding RNAs which act as versatile regulators, influencing gene express...
The Catsper3 promoter activity is regulated by the cAMP-Response Element Modulator tau (CREMτ) and the cAMP-Response Element Binding protein 1A (CREBA) transcription factors [0.03%]
Catsper3启动子活性受cAMP反应元件调节蛋白τ(CREMτ)和cAMP反应元件结合蛋白1A(CREBA)转录因子的调控
Diego Eduardo Sánchez-Jasso,Sergio Federico López-Guzmán,Javier Hernández-Sánchez et al.
Diego Eduardo Sánchez-Jasso et al.
Catsper3 has been shown to be essential for the proper functioning of CatSper calcium channel, sperm hyperactivation and egg fertilization. Although its function and physiological relevance to male fertility have been characterized, nothing...
Expression of CMK2 is controlled by the general stress-response transcriptional factor Msn2 through a single STRE site in budding yeast [0.03%]
酿酒酵母CMK2的表达通过启动子上的单个STRE元件受一般应激反应转录因子Msn2调控
Linghuo Jiang,Yiying Gu,Liudan Wei et al.
Linghuo Jiang et al.
Mammalian calcium/calmodulin-dependent protein kinase II (CaMKII) is a memory molecule in the brain, and regulates fatty acids and lipid metabolism. As a yeast homolog of CaMKII, Cmk2 is a negative feed-back regulator of calcium signaling i...
A putative PIWIL/piRNA-OTX2 network: An emerging model for epigenetic regulation of cancer stemness in retinoblastoma [0.03%]
假定的PIWIL/piRNA-OTX2网络：视网膜母细胞瘤干细胞表观遗传调控新兴模型
Rupa Roy,Subbulakshmi Chidambaram
Rupa Roy
Recent findings underscore the critical role of PIWIL/piRNA pathways in cancer, extending their known functions beyond reproductive biology. Retinoblastoma (RB), a rare pediatric retinal tumor, is primarily driven by RB1 gene loss but also ...
Functional characterization of promoter regions in selenoprotein synthesis-relevant genes (sbp2, eefsec and sepsecs) and their selenium-dependent regulation in yellow catfish Pelteobagrus fulvidraco [0.03%]
黄颡鱼(sbp2，eefsec和sepsecs)硒蛋白合成相关基因启动子区的功能表征及其硒依赖性调控
Kai Zhang,An-Gen Yu,Hua Zheng et al.
Kai Zhang et al.
The study explored the transcriptional regulation of selenoprotein synthesis-relevant genes, such as selenocysteine insertion sequence element binding protein 2 (sbp2), eukaryotic elongation factor (eefsec) and o-phosphoserine selenocystein...
Transposon insertion causes ctnnb2 transcript instability that results in the maternal effect zebrafish ichabod (ich) mutation [0.03%]
转座子插入引起ctnnb2转录本不稳定导致斑马鱼母体效应突变体Ichabod(ich)
Zsombor Varga,Ferenc Kagan,Shingo Maegawa et al.
Zsombor Varga et al.
The maternal-effect mutation ichabod (ich) results in ventralized zebrafish embryos due to impaired induction of the dorsal canonical Wnt-signaling pathway. While previous studies linked the phenotype to reduced ctnnb2 transcript levels, th...