From reconstruction to intervention: Engineered organoids as living therapeutic depots [0.03%]
从重建至干预：工程器官体作为活性治疗储存库
Lu Wang,Yan Pang,Jinyao Liu
Lu Wang
Wang et al. engineer mammary organoids as anticancer drug-secreting depots that inhibit post-surgical tumor recurrence and regenerate functional mammary gland tissue.1 This work extends the therapeutic utility of organoids beyond tissue rec...
Bi-Sen Ding,Biao Yang,Zhongwei Cao
Bi-Sen Ding
In a long-term follow-up of a phase 1/2 clinical trial, Stuart Forbes and colleagues demonstrate that autologous macrophage therapy improves transplantation-free survival in patients with liver cirrhosis. These findings show the translation...
Beyond apoptosis: LSC state dictates metabolic and anti-apoptotic vulnerabilities [0.03%]
超越凋亡：LSC状态决定代谢和抗凋亡弱点
Juan L Coelho-Silva,João A Machado-Neto
Juan L Coelho-Silva
Two studies1,2 published in the last issue of Cell Stem Cell reveal that leukemic stem cell (LSC) identity in acute myeloid leukemia (AML) encodes both anti-apoptotic dependencies and metabolic survival programs. They reframe LSC-directed t...
Outside the niche: Gut microbiota relay psychological stress to hematopoietic stem cell dysfunction [0.03%]
Niches之外：肠菌介导心理压力引起造血干细胞功能障碍
Haiyan Zhou,Yuxi Wei,Dachuan Zhang
Haiyan Zhou
Hematopoietic stem cells integrate local and systemic cues to sustain blood homeostasis. In this issue of Cell Stem Cell, Tian et al.1 uncover a stress-responsive brain-gut-bone marrow axis that drives aging-like dysfunction of hematopoieti...
Modeling human hypothalamic cell diversity through developmental patterning [0.03%]
通过发育模式模拟人类下丘脑细胞多样性
Sol Díaz de León-Guerrero,Zhiping P Pang
Sol Díaz de León-Guerrero
Understanding the cellular diversity of the human hypothalamus has been limited by the lack of accessible models. In this issue of Cell Stem Cell, Abay-Nørgaard et al.1 demonstrate that temporal control of BMP signaling during human plurip...
From repair to relay: Human retinal organoids re-couple a severed optic nerve [0.03%]
从修复到中继：人类视网膜类器官重新连接切断的视神经
Kevin Achberger,Stefan Liebau
Kevin Achberger
Restoring vision after complete optic nerve transection has long seemed out of reach. In this issue of Cell Stem Cell, Gong et al.1 now show that human retinal organoids transplanted into the lesion form a chimeric host-graft bridge capable...
Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis [0.03%]
患者衍生器官样物显示慢性胰腺炎中的导管功能障碍和CFTR调节剂反应
Victoria Osorio-Vasquez,Jonathan Zhu,Jan C Lumibao et al.
Victoria Osorio-Vasquez et al.
Chronic pancreatitis (CP) affects ∼3 million people worldwide, yet altering the course of the disease is challenging. We developed a patient-derived organoid (PDO) platform to investigate the molecular pathogenesis of this disease and iden...
Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis [0.03%]
GATA6缺失诱导的谱系塑性促进结直肠癌转移
Saori Goto,Vikram Deshpande,Ömer H Yilmaz et al.
Saori Goto et al.
Colorectal cancer (CRC) liver metastases are the leading cause of CRC-related mortality, yet the genetic and epigenetic drivers underlying this process remain poorly understood. Here, we established a pro-metastatic CRC organoid library thr...
Quantitative molecular cartography of emergency myelopoiesis reveals conserved modules of hematopoietic activation [0.03%]
量化分子图谱揭示应急髓样细胞生成中造血激活的保守模块
James W Swann,Jun Hou Fung,Ziwei Chen et al.
James W Swann et al.
Hematopoietic stem and progenitor cells (HSPCs) respond to infections, inflammation, and regenerative challenges using emergency myelopoiesis (EM) pathways to amplify myeloid cell production. However, it remains unclear how various EM induc...
Paired pre- and post-transplant human immunoprofiling identifies an IFN-γ-JAK1 axis limiting stem-cell-derived RPE engraftment [0.03%]
配对的移植前后人类免疫谱分析鉴定出一个IFN-γ-JAK1轴限制干细胞来源视网膜色素上皮细胞移植物存活
Junfeng Ma,Lifu Zhu,Ping Duan et al.
Junfeng Ma et al.
Neovascular age-related macular degeneration is a major cause of irreversible blindness, and current therapies do not restore photoreceptors or retinal pigment epithelium (RPE). Human embryonic stem-cell-derived RPE (hESC-RPE) transplantati...