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Outside the niche: Gut microbiota relay psychological stress to hematopoietic stem cell dysfunction

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Hematopoietic stem cells integrate local and systemic cues to sustain blood homeostasis. In this issue of Cell Stem Cell, Tian et al.1 uncover a stress-responsive brain-gut-bone marrow axis that drives aging-like dysfunction of hematopoietic stem cells. ... ...