Cardiopedia-Ligand: A ligand-receptor perturbation atlas of human cardiac organoid function and transcriptional state [0.03%]
心脏器官类器官功能和转录状态的配体受体扰动图谱CARDIOPEDIA-LIGAND
Janice D Reid,Simon R Foster,Mary Lor et al.
Janice D Reid et al.
Large-scale perturbation atlases have transformed systems biology, yet no equivalent resource exists for the human heart, where contractile function and transcriptomic state must be measured together. Here, we establish Cardiopedia-Ligand, ...
Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis [0.03%]
间充质基质细胞的细胞外囊泡分泌组通过靶向心脏纤维化预防缺血性心力衰竭
Karl-Henrik Grinnemo,Ken Braesch-Andersen,Johan O Wedin et al.
Karl-Henrik Grinnemo et al.
Myocardial ischemia-reperfusion (MIR) injury drives adverse remodeling and heart failure after ST-elevation myocardial infarction (STEMI), yet no therapy directly targets the fibrotic response. Here, we developed a good manufacturing practi...
Dissecting divergent outcomes in stem cell-derived dopamine cell therapy trials for Parkinson's disease [0.03%]
解析多巴胺能细胞治疗帕金森病临床试验的异质性结果
Chan Wook Park,Sanghyun Park,Seok Jong Chung et al.
Chan Wook Park et al.
Fetal tissue transplantation established proof-of-concept for dopamine cell replacement in Parkinson's disease but yielded inconsistent outcomes due to limited tissue availability and cellular heterogeneity. Advances in generating high-puri...
Shosei Yoshida
Shosei Yoshida
Using a xenogeneic reconstituted testis transplanted beneath the kidney capsule, Whelan et al. advance human and rhesus macaque pluripotent stem cell-derived germ cells beyond fetal prospermatogonia.1 Their study highlights developmental ti...
Human iPSC-derived engineered heart tissue model of diastolic dysfunction in heart failure with preserved ejection fraction [0.03%]
用于保留射血分数心力衰竭患者舒张功能障碍的人类iPSC衍生工程心脏组织模型
Hidenori Tani,Kotaro Haga,Taijun Moriwaki et al.
Hidenori Tani et al.
The prognosis for heart failure (HF) with preserved ejection fraction (HFpEF) remains poor, with treatment evidence and studies at the human cellular level limited. Here, we aimed to model HFpEF-associated diastolic dysfunction in vitro by ...
Vitamin C attenuates primate bone marrow aging at the molecular and progenitor level [0.03%]
维生素C通过分子和祖细胞水平减轻类人猿骨髓衰老
Yanxia Ye,Honghao Zhang,Zijuan Xin et al.
Yanxia Ye et al.
Bone marrow aging compromises hematopoiesis and immunity, yet whether these processes are modifiable in primates remains unexplored. Here, we map the single-cell transcriptomic landscape of primate bone marrow aging and demonstrate that lon...
Generation of spermatogonia from human and non-human primate pluripotent stem cells [0.03%]
人和非人灵长类诱导多能干细胞向生殖细胞分化
Eoin C Whelan,Mingyue Guo,Ryo Yokomizo et al.
Eoin C Whelan et al.
Failures in germline development drive male infertility, but the lack of model systems that recapitulate human spermatogenesis hampers therapeutic development. Here, we develop a system to differentiate human-induced pluripotent stem cells ...
FDA-approved fulvestrant-induced CAR phase separation enables precise control of CAR T antitumor function [0.03%]
FDA批准的fulvestrant诱导的CAR相分离能够精确控制CAR-T抗肿瘤功能
Yuwei Huang,Qichen Zhang,Kun Wang et al.
Yuwei Huang et al.
Chimeric antigen receptor (CAR) T cell therapy faces challenges, such as tumor relapse due to antigen loss and poor CAR T cell expansion in vivo. Optimal tonic signaling (spontaneous CAR signaling) is crucial for CAR T cell fitness and anti...
Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone marrow axis [0.03%]
心理压力通过大脑-肠道-骨髓轴驱动衰老类似造血干细胞功能障碍
Xiaobin Tian,Binghuo Wu,Keyue Yang et al.
Xiaobin Tian et al.
Chronic stress influences hematopoietic stem cells (HSCs). However, how psychological stress regulates HSC function remains incompletely understood. Here, we show that psychological stress impairs HSC self-renewal and lymphoid differentiati...
Misao Fujita,Kyoko Akatsuka,Fujika Ariarakawa
Misao Fujita
Despite rapid advances in human stem cell-based embryo model (SCBEM) research, national regulatory frameworks remain limited. On April 1, 2026, Japan implemented revised guidelines extending their scope to encompass human SCBEM research. We...