Ziqi Dong,Niek Wit,Aastha Agarwal et al.
Ziqi Dong et al.
Human lungs experience dynamic oxygen tension during development. Here, we show that hypoxia directly regulates human lung epithelial cell identity using tissue-derived organoids. Fetal multipotent lung epithelial progenitors remain undiffe...
Stem cell research in space: Advancing regenerative medicine beyond Earth [0.03%]
空间中的干细胞研究：超越地球的再生医学的发展
Maedeh Mozneb,Madelyn Arzt,Jemima Moses et al.
Maedeh Mozneb et al.
Spaceflight provides a unique environment that profoundly influences stem cell biology. Experiments aboard the International Space Station (ISS) and in simulated microgravity have revealed altered stem cell proliferation, differentiation, a...
From sentinels to engineers: The future of microglia in brain regeneration [0.03%]
从守卫到工程师：大脑再生中小胶质细胞的未来研究方向
Muzhen Qiao,Peng Jiang
Muzhen Qiao
Recent studies highlight microglial replacement as a promising therapeutic approach for neurological disease. Wu et al.1 demonstrated that transplanted bone marrow-derived cells halted ALSP progression, while Mader et al.2 introduced a stra...
Jonathan Levinsohn,Katalin Susztak
Jonathan Levinsohn
In this issue of Cell Stem Cell, Huang et al.1 address the challenge of creating organoids that more closely replicate kidney spatial patterning and function. They develop region-specific progenitor assembloids mimicking native architecture...
Mind, mood and new neurons: Probing adult hippocampal neurogenesis in neuropsychiatry and beyond [0.03%]
大脑、心境与新生脑细胞：探究神经精神医学中的成人海马齿状回神经发生现象
Giorgia Tosoni,Evgenia Salta
Giorgia Tosoni
In this issue of Cell Stem Cell, Márquez-Valadez, Gallardo-Caballero, and Llorens-Martín1 report that adult hippocampal neurogenesis (AHN) is differentially disrupted in neuropsychiatric disorders. Their findings highlight the role of the...
Kevin M Waters,Akil Merchant,De-Chen Lin
Kevin M Waters
Chan et al.1 show that enteric neurons influence lipid metabolism in gastric cancer organoids, affecting dependencies on key enzymes. Using CRISPR screening and metabolic analysis, their work highlights how microenvironmental signals impact...
Xiangyu Kong,Thorold W Theunissen
Xiangyu Kong
The generation of stem-cell-based embryo models has ushered in a new era for human embryology, but improving their reproducibility and lineage fidelity has remained a challenge. In this issue of Cell Stem Cell, Chen et al.1 and Oura et al.2...
Zekun Wu,Hongan Ren,Leqian Yu
Zekun Wu
Two recent studies from the Silva and Hanna groups optimized chemical induction and culture conditions to derive extraembryonic lineages directly from embryonic stem cells (ESCs) without transgenes, enabling mouse stem cell-based embryo mod...
A mineralizing pool of Gli1-expressing progenitors builds the tendon enthesis and demonstrates therapeutic potential [0.03%]
Gli1表达前体细胞的矿化库构建腱 enthesis并展示其治疗潜力
Fei Fang,Yang Xiao,Elazar Zelzer et al.
Fei Fang et al.
Published Erratum
Cell stem cell. 2025 Sep 30:S1934-5909(25)00366-2. DOI:10.1016/j.stem.2025.09.010 2025
Spatially patterned kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling [0.03%]
空间分层的肾脏组装体再现前体细胞自组织并能够进行高保真的体内疾病建模
Biao Huang,Pedro Medina,Jincan He et al.
Biao Huang et al.
Current kidney organoids do not recapitulate the kidney's complex spatial patterning and function, limiting their applications. The human kidney comprises one million nephrons, derived from nephron progenitor cells, that connect to an arbor...