Space-associated stem cell hallmarks of aging and resilience in astronauts [0.03%]
太空中与干细胞相关的衰老和宇航员的适应性标志物
Jessica Pham,Shuvro P Nandi,Larisa Balaian et al.
Jessica Pham et al.
Previous reports revealed immune dysfunction, chromosomal abnormalities, cytokine deregulation, and telomere alterations after prolonged spaceflight. However, the stress of space on hematopoietic stem and progenitor cells (HSPCs) and the re...
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells [0.03%]
溶酶体功能逆转可恢复衰老造血干细胞的年轻状态
Tasleem Arif,Jiajing Qiu,Hossein Khademian et al.
Tasleem Arif et al.
Aging impairs hematopoietic stem cells (HSCs), driving clonal hematopoiesis, myeloid malignancies, and immune decline. The role of lysosomes in HSC aging-beyond their passive mediation of autophagy-is unclear. We show that lysosomes in aged...
Macro-scale, scaffold-assisted model of the human bone marrow endosteal niche using hiPSC-vascularized osteoblastic organoids [0.03%]
基于hiPSC-血管化成骨器官体的大型终末骨髓生态位模型研究
Qing Li,Marina T Nikolova,Gangyu Zhang et al.
Qing Li et al.
Endosteal bone marrow (BM) niches are crucial to sustain non-steady-state hematopoiesis but are challenging to be modeled in their cellular and molecular complexity in standardized, human settings. We report a developmentally guided approac...
Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages [0.03%]
簇类蛋白阳性心肌细胞通过重新编程巨噬细胞来抑制炎症和促进新生儿和成人的心脏再生
Lei Fan,Qi Tang,Yutong Wang et al.
Lei Fan et al.
Adult hearts scar after injury, while neonatal hearts regenerate. The mechanisms underlying this dichotomy remain unclear. Through comparative spatiotemporal single-cell analyses and dual recombinase-mediated lineage tracing, we uncovered a...
Tissue regeneration: Unraveling strategies for resolving pathological fibrosis [0.03%]
组织再生：解开解决病理性纤维化的策略之谜
Jiao Li,Shuyong Wang,Jie Yuan et al.
Jiao Li et al.
Tissues are constantly exposed to stresses that cause both cellular and structural damage. In response, a coordinated healing process restores tissue integrity and functionality. When these stresses persist or the healing process becomes dy...
RPE replacement therapy for dry AMD-early success in a phase 1/2 clinical trial [0.03%]
视网膜色素上皮细胞替代疗法治疗干性年龄相关性黄斑变性疾病一期/二期临床试验早期结果良好
Renee C Ryals
Renee C Ryals
The number of retinal pigment epithelium (RPE) transplantation clinical trials for dry age-related macular degeneration (AMD) is increasing quickly, with groups using different stem cell sources, delivery approaches, and immune suppression....
Clinical Trial
Cell stem cell. 2025 Nov 6;32(11):1637-1638. DOI:10.1016/j.stem.2025.10.007 2025
Clare L Parish
Clare L Parish
Low yields of dopamine neurons in human stem cell-derived neural grafts limit their potential for treating Parkinson's disease. Zhang et al.1 develop a new three-dimensional differentiation method, informed and refined through careful clona...
Senolytic-sensitive p16Ink4a+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity [0.03%]
肿瘤基质中的senolytic敏感性p16ink4a阳性成纤维细胞可重塑肺癌代谢和表型可塑性
Jin Young Lee,Nabora Reyes,Sang-Ho Woo et al.
Jin Young Lee et al.
Senescence has been demonstrated to either inhibit or promote tumorigenesis. Resolving this paradox requires spatial mapping and functional characterization of senescent cells in the native tumor niche. Here, we identify p16Ink4a+ cancer-as...
A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders [0.03%]
神经发育障碍的脑器官表型图谱和生物库
Lu Wang,Yuji Nakamura,Junhao Li et al.
Lu Wang et al.
Thousands of genes are associated with neurodevelopmental disorders (NDDs), yet mechanisms and targeted treatments remain elusive. To fill these gaps, we present a California Institute of Regenerative Medicine (CIRM)-initiated NDD biobank o...
Generation of human nucleus basalis organoids with functional nbM-cortical cholinergic projections in transplanted assembloids [0.03%]
人基底前脑类器官的生成及其在移植复合体中的功能化神经投影
Da Wang,Xinyue Zhang,Xiao-Yan Tang et al.
Da Wang et al.
The nucleus basalis of Meynert (nbM), the major cholinergic output of the basal forebrain, regulates cortical modulation, learning, and memory. Dysfunction of the nbM-cortical cholinergic pathway is implicated in neurodegenerative and neuro...