Tumour microbiota activities associated with local recurrence in ER + PR + breast cancer [0.03%]
ER+PR+型乳腺癌患者局部复发与肿瘤微生物组的相关性研究
Sean Si Qian Ma,Luyi Ye,Fan Zhang et al.
Sean Si Qian Ma et al.
PurposeThis study aimed to compare tumour microbiota characteristics as potential recurrence predictors in estrogen receptor-positive (ER+) and progesterone receptor-positive (PR+) breast cancer.MethodsFormalin-fixed paraffin-embedded (FFPE...
Unraveling the role of PREX2 mutations as a biomarker for immunotherapy response in colorectal cancer [0.03%]
揭示PREX2突变作为免疫治疗反应生物标志物在结直肠癌中的作用
Huan Peng,Pengmin Yang,Xintao Wang et al.
Huan Peng et al.
IntroductionImmunotherapy benefits gastrointestinal tumor patients. But traditional biomarkers like TMB and MSI can't precisely identify beneficiaries. Phosphatidylinositol - 3,4,5 - triphosphate - dependent Rac exchange factor 2 (PREX2) pl...
Machine learning-driven gene expression profiling for lung cancer stage determination [0.03%]
基于机器学习的肺癌分期基因表达谱分析
Yinbo Wang,Kai Fu
Yinbo Wang
BackgroundLung cancer remains a leading cause of cancer-related mortality, with accurate staging essential for guiding treatment. Advances in next-generation sequencing (NGS) and machine learning (ML) enable more precise classification, imp...
Role of immune cell subsets in liver fibrosis through single-cell RNA sequencing and array [0.03%]
通过单细胞RNA测序和微阵列探讨肝纤维化免疫细胞亚群的作用
Bo Yang,Junjie Yuan,Jingwen Zhao et al.
Bo Yang et al.
BackgroundImmune-inflammatory responses and dysregulation play a key role in liver fibrosis (LF) and cirrhosis progression, but the phenotypic and functional dynamics of immune cell populations remain poorly characterized.MethodsLF-related ...
PDCD2L overexpression represents an unfavorable prognostic marker and its inhibition shows promising therapeutic potential for gastric cancer [0.03%]
PDCD2L过表达代表不良预后标志及其抑制显示出治疗胃癌的潜力
Ding-Ping Sun,Chun-Chao Chang,Hsuan-Yi Huang et al.
Ding-Ping Sun et al.
BackgroundGastric cancer is the 4th most common and 3rd deadliest cancer worldwide. Research has shown that PDCD2-like (PDCD2L) is elevated in several tumors.ObjectiveTo explore the relationship between PDCD2L expression and gastric cancer ...
A risk model based on signature genes predicts prognosis and associates with tumor immunity, drug sensitivity in breast cancer [0.03%]
基于签名基因的预测乳腺癌预后的风险模型及其与肿瘤免疫和药物敏感性的关联性研究
Yuan Li,Hao Li,Jichuan Quan et al.
Yuan Li et al.
BackgroundBreast cancer, the leading cause of cancer deaths among women, exhibits high heterogeneity, affecting prognosis. Understanding this heterogeneity and developing prognostic models are crucial for accurate identification of high-ris...
Hsa_circ_0101308 adjusted by N6-methyladenosine (m6A) impacts chemo-resistance in cervical cancer via sponging miR-224 [0.03%]
N6-甲基腺苷（m6A）调节的环状RNA Hsa_circ_0101308通过海绵吸附miR-224影响宫颈癌的耐药性
Li Shang,Ruchun Yan,Heng Wang et al.
Li Shang et al.
BackgroundConsidering the significance of circRNA-miRNA network underlying cervical cancer (CC) development, this investigation was devised to explore whether and how 6-methyladinosinek (m6A)-adjusted hsa_circ_0101308/miR-224 axis participa...
Knockdown of MACC1 expression attenuates colorectal cancer cell glucose metabolism by suppressing GLUT4 membrane translocation [0.03%]
MACC1基因敲低通过抑制GLUT4膜转运削弱结直肠癌细胞葡萄糖代谢
Qingke Li,Yankun Liu,Zhiwu Wang et al.
Qingke Li et al.
BackgroundMetastasis-associated in colon cancer-1 (MACC1) is a novel oncogene involved in the growth and metastasis of tumors, which is overexpression in various tumors. MACC1 could promote the growth, invasion, and metastasis of colorectal...
Polyclonal plasma cell (PolyPC) signature as a key indicator for predicting the progression of MGUS to multiple myeloma [0.03%]
多克隆浆细胞(PolyPC)特征作为预测MGUS进展为多发性骨髓瘤的关键指标
Fumou Sun,Yan Cheng,Catherine Ma et al.
Fumou Sun et al.
BackgroundMultiple myeloma (MM) is virtually always preceded by monoclonal gammopathy of undetermined significance (MGUS). Elevated serum markers are used to classify MGUS patients into clinical risk categories. Previous research has indica...