The overexpression of HOXC6 in LUSC and pan-squamous cell carcinomas indicates the coexistence of nuclear division regulatory mechanisms [0.03%]
HOXC6在LUSC和所有鳞状细胞癌中的过度表达表明了分裂机制共存的现象
Shu-Jia He,Ke-Jun Wu,Yi-Yang Chen et al.
Shu-Jia He et al.
BackgroundHomeobox C6 (HOXC6) shows abnormal expression in various tumors, but its pattern in lung squamous cell carcinoma (LUSC) remains unclear.ObjectiveTo investigate HOXC6's expression and function in LUSC.MethodsHOXC6 expression was an...
The predictive effect of the CD155-TIGIT immune checkpoint axis complex on neoadjuvant chemotherapy efficacy in triple-negative breast cancer: A preliminary study [0.03%]
CD155-TIGIT免疫检查点轴复合物对三阴性乳腺癌新辅助化疗疗效的预测价值：初步研究
Keyu Yuan,Xin Ou,Shuzhen Lyu et al.
Keyu Yuan et al.
BackgroundThe CD155-TIGIT axis, a breast cancer progression biomarker, underscored neoadjuvant chemotherapy (NAC) response variability in triple-negative breast cancer (TNBC), urging biomarker-based patient stratification for timely therapy...
TUBB3 (βIII-tubulin) drives gastric cancer progression and poor prognosis by regulating cell cycle and invadopodia formation [0.03%]
TUBB3（βIII-微管蛋白）通过调节细胞周期和侵袭小体形成驱动胃癌进展和不良预后
Hui Ge,Hui Tang,Tingting You et al.
Hui Ge et al.
BackgroundGastric cancer is the fifth most common malignancy and third leading cause of cancer death in China, with advanced-stage five-year survival below 20%. βIII-tubulin (TUBB3) is overexpressed in cancers but its role in gastric cance...
Combination detection of IgG- and IgA-related autoantibodies for the early diagnosis of gastric cancer [0.03%]
用于胃癌早期诊断的IgG和IgA相关自身抗体联合检测
Congcong Fu,Tao Wang,Xianzhu Zhou et al.
Congcong Fu et al.
BackgroundAutoantibodies against tumor-associated antigens (TAAs) are promising noninvasive cancer biomarkers due to their specificity and stability. Gastric cancer (GC) diagnosis often requires invasive procedures, emphasizing the need for...
Tumour microbiota activities associated with local recurrence in ER + PR + breast cancer [0.03%]
ER+PR+型乳腺癌患者局部复发与肿瘤微生物组的相关性研究
Sean Si Qian Ma,Luyi Ye,Fan Zhang et al.
Sean Si Qian Ma et al.
PurposeThis study aimed to compare tumour microbiota characteristics as potential recurrence predictors in estrogen receptor-positive (ER+) and progesterone receptor-positive (PR+) breast cancer.MethodsFormalin-fixed paraffin-embedded (FFPE...
Unraveling the role of PREX2 mutations as a biomarker for immunotherapy response in colorectal cancer [0.03%]
揭示PREX2突变作为免疫治疗反应生物标志物在结直肠癌中的作用
Huan Peng,Pengmin Yang,Xintao Wang et al.
Huan Peng et al.
IntroductionImmunotherapy benefits gastrointestinal tumor patients. But traditional biomarkers like TMB and MSI can't precisely identify beneficiaries. Phosphatidylinositol - 3,4,5 - triphosphate - dependent Rac exchange factor 2 (PREX2) pl...
Machine learning-driven gene expression profiling for lung cancer stage determination [0.03%]
基于机器学习的肺癌分期基因表达谱分析
Yinbo Wang,Kai Fu
Yinbo Wang
BackgroundLung cancer remains a leading cause of cancer-related mortality, with accurate staging essential for guiding treatment. Advances in next-generation sequencing (NGS) and machine learning (ML) enable more precise classification, imp...
Role of immune cell subsets in liver fibrosis through single-cell RNA sequencing and array [0.03%]
通过单细胞RNA测序和微阵列探讨肝纤维化免疫细胞亚群的作用
Bo Yang,Junjie Yuan,Jingwen Zhao et al.
Bo Yang et al.
BackgroundImmune-inflammatory responses and dysregulation play a key role in liver fibrosis (LF) and cirrhosis progression, but the phenotypic and functional dynamics of immune cell populations remain poorly characterized.MethodsLF-related ...
PDCD2L overexpression represents an unfavorable prognostic marker and its inhibition shows promising therapeutic potential for gastric cancer [0.03%]
PDCD2L过表达代表不良预后标志及其抑制显示出治疗胃癌的潜力
Ding-Ping Sun,Chun-Chao Chang,Hsuan-Yi Huang et al.
Ding-Ping Sun et al.
BackgroundGastric cancer is the 4th most common and 3rd deadliest cancer worldwide. Research has shown that PDCD2-like (PDCD2L) is elevated in several tumors.ObjectiveTo explore the relationship between PDCD2L expression and gastric cancer ...