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Unraveling the role of PREX2 mutations as a biomarker for immunotherapy response in colorectal cancer

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IntroductionImmunotherapy benefits gastrointestinal tumor patients. But traditional biomarkers like TMB and MSI can't precisely identify beneficiaries. Phosphatidylinositol - 3,4,5 - triphosphate - dependent Rac exchange factor 2 (PREX2) plays a complex role ... ...