The impact of HER2 low positivity in hormone receptor-positive, HER2-negative breast cancer treated with neoadjuvant chemotherapy [0.03%]
HER2低阳性对激素受体阳性、HER2阴性乳腺癌新辅助化疗的影响
Mustafa Ersoy
Mustafa Ersoy
AimsThis study aimed to investigate whether the efficacy of neoadjuvant chemotherapy differs between HER2-low and HER2-zero subgroups in hormone receptor-positive, HER2-negative breast cancer.Materials and MethodsA total of 61 patients who ...
A panel of plasma proteins associated with venous thromboembolism in patients with prostate cancer [0.03%]
前列腺癌患者静脉血栓形成的血浆蛋白谱系分析
Asha Jose,Simon Lu,Chao Zhang et al.
Asha Jose et al.
PurposeVenous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a leading cause of morbidity and mortality in cancer patients. Prostate cancer is associated with an elevated risk of VTE, yet the molecular driv...
Serum exosomal miR-1275 as a potential biomarker for the diagnosis and prognostic assessment of hepatocellular carcinoma [0.03%]
血清外泌体miR-1275作为肝细胞癌诊断和预后评估潜在生物标志物的研究
Yang Jun,Chen Yeng,Shen Sainan et al.
Yang Jun et al.
BackgroundHepatocellular carcinoma (HCC) is a major global health burden, with limited tools for early diagnosis and prognosis. This study explores serum-derived exosomal miR-1275 as a potential non-invasive biomarker for HCC.MethodsExosome...
CD137L and colorectal cancer prognosis: Insights from clinical and TCGA data analysis [0.03%]
CD137L与结直肠癌预后的关系：来自临床和TCGA数据分析的启示
Kaiyu Xu
Kaiyu Xu
BackgroundCD137L plays a substantial role in immune regulation and has been associated with tumor progression. However, its expression pattern and clinical significance in colorectal cancer remain unclear. The current study was planned to e...
Characterization of a novel four-miRNA signature in papillary thyroid carcinoma: Integrating molecular profiling, hormonal regulation, and diagnostic implications in populations with rising PTC incidence [0.03%]
一种新型的四个microRNA标志物在乳头状甲状腺癌中的特征描述：整合分子谱型、激素调节和诊断意义以应对不断上升的PTC发病率人群
Afshan Afzal,Nafeesa Kainat,Aayesha Riaz et al.
Afshan Afzal et al.
Diagnosing papillary thyroid carcinoma (PTC) remains challenging, particularly due to limitations in fine-needle aspiration biopsy (FNAB), which yields up to 10% nondiagnostic results. The objective of this study was to evaluate the diagnos...
SLAMF8 expression and prognostic significance in melanoma: A multi-omics and Mendelian randomization study [0.03%]
SLAMF8在黑色素瘤中的表达及预后意义：一项多组学和孟德尔随机化研究
Jianjiang Liu,Wei Han,Guoliang Shen
Jianjiang Liu
BackgroundMelanoma represents one of the most aggressive skin cancers, responsible for over 75% of skin cancer-related deaths despite comprising only 5% of cases. Despite therapeutic advances, patient responses remain variable and unpredicv...
The overexpression of HOXC6 in LUSC and pan-squamous cell carcinomas indicates the coexistence of nuclear division regulatory mechanisms [0.03%]
HOXC6在LUSC和所有鳞状细胞癌中的过度表达表明了分裂机制共存的现象
Shu-Jia He,Ke-Jun Wu,Yi-Yang Chen et al.
Shu-Jia He et al.
BackgroundHomeobox C6 (HOXC6) shows abnormal expression in various tumors, but its pattern in lung squamous cell carcinoma (LUSC) remains unclear.ObjectiveTo investigate HOXC6's expression and function in LUSC.MethodsHOXC6 expression was an...
The predictive effect of the CD155-TIGIT immune checkpoint axis complex on neoadjuvant chemotherapy efficacy in triple-negative breast cancer: A preliminary study [0.03%]
CD155-TIGIT免疫检查点轴复合物对三阴性乳腺癌新辅助化疗疗效的预测价值：初步研究
Keyu Yuan,Xin Ou,Shuzhen Lyu et al.
Keyu Yuan et al.
BackgroundThe CD155-TIGIT axis, a breast cancer progression biomarker, underscored neoadjuvant chemotherapy (NAC) response variability in triple-negative breast cancer (TNBC), urging biomarker-based patient stratification for timely therapy...
TUBB3 (βIII-tubulin) drives gastric cancer progression and poor prognosis by regulating cell cycle and invadopodia formation [0.03%]
TUBB3（βIII-微管蛋白）通过调节细胞周期和侵袭小体形成驱动胃癌进展和不良预后
Hui Ge,Hui Tang,Tingting You et al.
Hui Ge et al.
BackgroundGastric cancer is the fifth most common malignancy and third leading cause of cancer death in China, with advanced-stage five-year survival below 20%. βIII-tubulin (TUBB3) is overexpressed in cancers but its role in gastric cance...