Darunavir: A Versatile Protease Inhibitor against Microbial Infections [0.03%]
达芦那韦：一种 versatile 的蛋白酶抑制剂以应对微生物感染
Mridul Singh Sengar,Kalpana Rahate,Megha Verma
Mridul Singh Sengar
Microbial infections continue to pose significant threats to global health, necessitating the development of innovative therapeutic strategies. One promising avenue is the use of protease inhib-itors, with darunavir (DRV) emerging as a pote...
Anti-Cancer Potential of Scopoletin Derivatives Across Diverse Cancer Cell Lines: A Comprehensive Review [0.03%]
scopoletin衍生物的抗肿瘤潜力：综述各类癌细胞系的研究成果
Manvi Karayat,Niranjan Kaushik,Deepika Paliwal et al.
Manvi Karayat et al.
Scopoletin, a naturally occurring coumarin derivative, has garnered significant attention for its diverse pharmacological properties, including potent anticancer activity. This review provides a comprehensive examination of scopoletin's ant...
Superfoods in Drug Discovery: Nutrient Profiles and their Emerging Health Benefits [0.03%]
超级食物在药物发现中的作用：营养成分及其不断涌现的健康效益
Ravi Kumar Mittal,Vikram Sharma,Gaurav Krishna
Ravi Kumar Mittal
Objective: This extensive review aims to cover the health and nutritional benefits of su-perfoods. It also discusses the macro- and micronutrients of amla, maca, jackfruit, Brazil nuts, and goji berries. Additionally, we ...
Structure-based Virtual Screening and Hit Identification of Novel designed Quinazolin-4(3H)-one Derivatives as Antitubercular Agent Against targets Polyketide Synthase 13 and DNA gyrase of Mycobacterium tuberculosis [0.03%]
基于结构的虚拟筛选及新型喹唑啉杂环衍生物抗结核药物设计、成药性评价及分子机制研究
Revathi G,Sowmiya P,Girija K
Revathi G
Background: After COVID-19, tuberculosis remained the world's second most infectious fatal disease in 2022, with about 410 million people developing MDR TB, according to WHO. The fast increase of MDR and XDR-TB has posed ...
Effective Integration of Artificial Intelligence and Blockchain Technologies for Empowerment of Drug Discovery and Development [0.03%]
人工智能和区块链技术在药物研发中的有效融合与应用探究
Virendra S Gomase,Devendra L Visokar,Vitthal V Chopade
Virendra S Gomase
The effective integration of blockchain technology and artificial intelligence (AI) has the potential to change healthcare management. Two cutting-edge developments in the healthcare indus-try are blockchain and artificial intelligence. Blo...
In Silico Development and Characterization of Nisoldipine Analogues for Enhanced Solubility and Therapeutic Potential in the Treatment of Angina Pectoris [0.03%]
用于增强可溶性和胸痛治疗药物疗效的尼索地平类似物的计算机辅助设计与表征
Pavankumar Krosuri,Mothilal Mohan
Pavankumar Krosuri
Background: Angina pectoris, a common cardiovascular condition, necessitates the de-velopment of effective therapeutic agents. Nisoldipine, a calcium channel blocker, and its analogues have shown potential in treating thi...
Biological Activity and Therapeutic Potential of Coumarin Derivatives: A Comprehensive Review [0.03%]
衍生物的生物活性和治疗潜力：全面综述
Shristi Singh,Niranjan Kaushik,Ajita Paliwal et al.
Shristi Singh et al.
Coumarins, naturally occurring benzopyrones, have garnered significant attention due to their diverse pharmacological activities and therapeutic potential. Derived from natural sources and synthetic routes such as the Perkin and Pechmann re...
A Narrative Review of the Nutritional Value and Biological Properties of Mushrooms [0.03%]
关于蘑菇的营养价值和生物学特性的叙述性评论
Monalisa Gochhi,Priyanka Dash,Niranjan Chinara et al.
Monalisa Gochhi et al.
The temperate, subtropical climates of Odisha state, India, provide significant benefits that can help it become a potent producer of many species of edible mushrooms. The importance of mush-rooms in diets has gained more attention in recen...
An In-Silico Investigation of the Potential of Vitamin D as a 5-HT1A Receptor Agonist: A Molecular Modeling Approach for Evaluating its Pharmacological Prospects [0.03%]
维生素D作为5-ht1a受体激动剂的潜力的计算机模拟研究：一种评估其药理学前景的分子建模方法
Houda Filali,Mohammed Mouhcine,Ibtihal Segmani et al.
Houda Filali et al.
Background: Vitamin D plays a crucial role in maintaining muscle and bone health and has been increasingly implicated in neurological disorders, including depression and anxiety, which are closely associated with dysregul...
Role of Biomarkers for Diagnosis and Prediction in Type 1 Diabetes: An Overview [0.03%]
自身免疫性1型糖尿病生物标志物的研究进展及临床应用前景展望
Omkar Janjire,Addepalli Veeranjaneyulu,Shivani Desai et al.
Omkar Janjire et al.
An autoimmune disorder known as type 1 diabetes (T1D) causes the pancreas to stop pro-ducing insulin. An autoimmune response against beta cells causes this metabolic condition, which is more typically observed in children and young adults a...