Breaking Boundaries in Cancer Therapy: Harnessing Chromothripsis- Induced Mutations for Targeted BCL2 Protein Destabilization
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Chromothripsis, a phenomenon of massive genomic rearrangements, introduces extensive mutations in critical genes, affecting cell survival and apoptosis. Among these genes, the BCL2 (B-cell lymphoma 2) gene, which plays a crucial antiapoptotic role in cancer ce... ...