Phytochemical-based Neuroprotection and In-silico Docking-driven Identification of Active Natural Compounds to Combat Neuropathy [0.03%]
基于植物化学的神经保护和计算对接驱动的抗神经病变活性天然化合物的识别
Swathi V,Chandru R,Shabna Roupal Morais et al.
Swathi V et al.
Introduction: Neuropathic pain, a devastating neurological disorder attributed to impairment or malfunctioning of the somatosensory system, affecting 10% of the world population. Current therapy emphasizes symptomatic man...
Discovery of Phytochemicals as Inhibitors of Human Metapneumovirus: In-Silico Docking Studies [0.03%]
植物化学物质作为人副流感病毒抑制剂的发现：基于计算的对接研究
Veerachamy Alagarsamy,Mohaideen Thasthagir Sulthana,Viswas Raja Solomon et al.
Veerachamy Alagarsamy et al.
Introduction: Human metapneumovirus (HMPV) remains a leading cause of severe paediatric and geriatric respiratory morbidity, manifesting in pathologies from bronchiolitis to pneumonia. Despite its clinical burden, no lice...
From Molecules to Manufacturing: Expanding Role of Artificial Intelligence in Pharmaceutical Sciences [0.03%]
从分子到制造：药学科学中人工智能作用的扩大
B Narasimha Rao,S Nashrah Nasreen,S Abdur Rehman et al.
B Narasimha Rao et al.
Artificial Intelligence (AI) addresses many complex problems by rapidly imitating human cognitive abilities. In the pharmaceutical industry, AI is transforming the processes of discovery, formulation, nanomedicine development, and manufactu...
Targeting Biofilm Formation in Acinetobacter baumannii: In Silico Discovery of Novel Candidate Inhibitors for Acyl-Homoserine Lactone Synthase [0.03%]
鲍曼不动杆菌生物被膜形成的药物靶点：计算机发现的独索菌酰-L-半乳氨酸合成酶抑制剂候选药物
Tejveer Singh,Rashmi Prabha Singh,Monika Jain et al.
Tejveer Singh et al.
Introduction: Acinetobacter baumannii, a Gram-negative member of the ESKAPE pathogens, has emerged as a pivotal cause of multidrug-resistant hospital-acquired or nosocomial infections worldwide. Its ability to regulate vi...
Effects of Ganoderma lucidum Polysaccharide Peptide on Inflammatory and Metabolic Biomarkers in Obese Patients with Cardiometabolic Syndrome: A Randomized Controlled Trial [0.03%]
灵芝多糖肽对心血管代谢综合征肥胖患者炎症及代谢标志物的影响：一项随机对照试验
Nuril Farid Abshori,Syanindita Wardhani,Fatahillah Fatoni et al.
Nuril Farid Abshori et al.
Background: Cardiometabolic syndrome (CMS) is a major contributor to atherosclerosis and cardiovascular events through persistent subclinical inflammation. While conventional pharmacotherapy addresses metabolic risk facto...
Using Computational Intelligence to Connect Data and Drug Design in Medicinal Chemistry: A Review [0.03%]
计算智能在药物设计中的应用：连接数据与药物设计的综述研究论文
Sujeet Maurya,Amrita Singh,Ajay Kumar et al.
Sujeet Maurya et al.
The landscape of drug discovery is being rapidly transformed by the integration of computational intelligence (CI) techniques with big data resources in medicinal chemistry. Traditional drug development methods are often time-consuming, cos...
Uncovering the Anti-Pleurisy Mechanism of Shizao Decoction via Network Pharmacology and Molecular Docking [0.03%]
基于网络药理学和分子对接技术揭示柴皂散抗肺纤维化的作用机制研究
Shaomin Huang,Shiyuan Zeng,Shanshan Du et al.
Shaomin Huang et al.
Objective: Shizao Decoction has been clinically applied for the treatment of pleurisy, but the specific biological mechanism underlying its therapeutic effects remains unclear. This study aims to explore the potential the...
Fused 1H-/2H-Indazole as Bioactive Privileged Scaffolds: Synthetic Strategies and Pharmaceutical Applications [0.03%]
用于药物开发的生物活性优先支架1H-/2H-吲唑的合成策略和药学应用研究
Richa Sharma,Amol T Mahajan,Vidit Shrivastava et al.
Richa Sharma et al.
Bioheterocycles represent a pharmaceutically privileged class of compounds due to their broad spectrum of medicinal applications. Among them, indazole (benzopyrazole or isoindazole) is a fused nitrogen-containing heterocycle with significan...
Role of Endogenous and Plant-based Exogenous Antioxidants in 5- Fluorouracil-mediated Synergistic Anticancer Activity in Breast Adenocarcinoma: Targeting NRF-2-mediated Antioxidant Pathways [0.03%]
内源性和植物来源外源性抗氧化剂在5-氟尿嘧啶介导的乳腺腺癌协同抗癌活性中的作用：针对NRF-2介导的抗氧化途径
Rajat Das,Himangshu Sekhar Maji,Pallab Kanti Haldar et al.
Rajat Das et al.
Background: 5-Fluorouracil (5-FU) is a chemotherapeutic drug commonly used to treat breast adenocarcinoma (BAC). Two primary challenges in treating BAC include drug resistance and weakening of the immune system. The flavo...
Evolving Global Regulatory Frameworks for Drug Discovery and Development: Harmonization and Future Directions [0.03%]
不断发展的药物研发全球监管框架：协调与未来方向
Virendra S Gomase,Rupali Sharma,Suchita P Dhamane et al.
Virendra S Gomase et al.
Introduction: Global regulatory frameworks for drug discovery and development have gradually evolved from fragmented, region-specific approaches to increasingly harmo-nized systems designed to reduce complexity and accele...