GABA Promoter and PDE4 Inhibitor in the Management of Polycystic Ovary Syndrome: A Nutraceutical Approach [0.03%]
用于多囊卵巢综合征管理的GABA促进剂和PDE4抑制剂：一种营养补充剂方法
Divyanshi Gupta,Lucy Mohapatra,Ankita Wal
Divyanshi Gupta
Introduction: PCOS, also known as polycystic ovary syndrome or condition, or Stein-Leventhal syndrome, is characterized by an imbalance in the luteinizing and follicular-stimulating hormones. Elevated levels of pro-inflam...
Revolutionizing Drug Discovery: Modern Advancements in Quality by Design, PAT Tools, and Green Chemistry [0.03%]
药物发现的革新：质量设计、PAT工具及绿色化学的现代进展
Soumyashree Tripathy,Suryakanta Swain,Bikash Ranjan Jena et al.
Soumyashree Tripathy et al.
Introduction: The main goal is to understand how quality by design, process analytical technologies, and green chemistry are used to improve the drug discovery process. These innovative approaches improve product quality,...
Discovery of Novel Red Algal Inhibitors Targeting African Swine Fever Virus dUTPase through Integrated Computational Screening [0.03%]
通过集成计算筛选发现 targeting非洲猪瘟病毒dutp酶的新红藻抑制剂
Razel F Melendez,Christelle Jane C Muyano,Mark Andrian B Macalalad et al.
Razel F Melendez et al.
Introduction: African swine fever virus (ASFV) is the causative agent of African swine fever, a highly lethal disease affecting domestic pigs and wild boars. Despite its first identification in East Africa in the early 19...
A Comprehensive Machine Learning Framework for Predicting Blood-Brain Barrier Permeability Enhanced by Ant Colony Optimization [0.03%]
基于蚁群优化的预测血脑屏障通透性的综合机器学习框架
Ahmed Miloudi,Mohamed Chikri,Said Boujraf
Ahmed Miloudi
Introduction: The blood-brain barrier (BBB) severely restricts drug delivery to the central nervous system (CNS). Early, accurate in silico prediction of BBB permeability is a critical challenge in drug discovery. This st...
Cyclic Peptides in Wound Hydrogels: Current Advances and Future Directions [0.03%]
伤口水凝胶中的环肽：当前进展与未来方向
Shahjad,Yashika Garg,Arun Kumar et al.
Shahjad et al.
Introduction: Chronic wounds, including diabetic foot ulcers and pressure ulcers, are significant clinical challenges due to impaired healing caused by chronic inflammation, poor angiogenesis, and Extracellular Matrix (EC...
Pharmacoinformatic Screening of Natural Compounds to Identify Potential GPER1 Inhibitors [0.03%]
基于药理信息学的天然产物GPER1抑制剂筛选研究
Rana Adnan Tahir,Srinivasa Rao Sirasanagandla
Rana Adnan Tahir
Introduction: GPER1 belongs to the large GPCR family, known for its diverse biological functions and therapeutic value in multiple diseases. It has gained attention for its role in mediating estrogenic signaling pathways,...
Exploring the Neurotherapeutic Potential of Bacillus-derived Macrolactins as NMDAR Antagonists for Alzheimer's disease: Network Pharmacology and Molecular Modeling Insights [0.03%]
芽孢杆菌衍生的巨环内酯类化合物作为NMDAR拮抗剂治疗阿尔茨海默病的神经治疗潜力研究：网络药理学和分子模拟见解
Rajaprabu Rajendran,Elavarashi Elangovan
Rajaprabu Rajendran
Background: The N-methyl-D-aspartate receptor (NMDAR) plays a critical role in regulating excitatory glutamatergic neurotransmission and synaptic plasticity. However, ex-cessive NMDAR activation can lead to increased calc...
Revolutionizing Ringworm Care: Holistic Advancements and Breakthrough Innovations [0.03%]
革新时代皮炎护理：整体进步与突破性创新
Kritika Sharma,M S Ashawat,Vinay Pandit
Kritika Sharma
Introduction: A frequent superficial fungal infection that affects keratinized tissues such as the skin, hair, and nails is dermatophytosis, sometimes referred to as ringworm. Microsporum, Epidermophyton, and Trichophyton...
The Protective Effects of Syzygium Jambolanum Extracts on Diabetes [0.03%]
Syzygium jambolanum提取物的护糖作用研究进展
Antara Roy,Dilip K Maiti,Bimal Krishna Banik
Antara Roy
Introduction: Syzygium jambolanum has long been used to treat diabetes mellitus in herbal therapy. Scientists are interested in confirming its effectiveness in reducing blood glucose and enhancing metabolic parameters thr...
Scrophularia striata Boiss. Facilitated the Green Synthesis of Silver Nanoparticles and their Biomedical Applications, a Panoramic View [0.03%]
条叶玄参促进银纳米颗粒的绿色合成及其生物医药应用的全面展望
Farhad Alipour,Mohammad M Zarshenas
Farhad Alipour
The main objective of this review is to evaluate the biomedical potential of silver nano-particles (NPs) synthesized using the medicinal plant Scrophularia striata Boiss. (S. striata), known for its traditional use in Asian folk medicine an...