Role of Exosomal miRNAs and Epigenetic Modifications in Diabetic Nephropathy: Insights into Novel Diagnostic and Therapeutic Strategies [0.03%]
糖尿病肾病中外泌体miRNA和表观遗传修饰的作用：新型诊断和治疗策略的启示
Srinivas Nagaram,Aniruddha Sen,Vijay Singh et al.
Srinivas Nagaram et al.
Introduction: Diabetic Nephropathy (DN) is a leading cause of chronic kidney disease and end-stage renal failure, highlighting the need for improved diagnostic and therapeutic strategies. This review examines the emerging...
Transcriptomic Signatures in TP53 Positive and Negative Tumor Samples in NSCLC [0.03%]
非小细胞肺癌中TP53阳性和阴性肿瘤样本的转录组标志物
Miao Xie,Baoguang Liu,Ziyi Chen et al.
Miao Xie et al.
Introduction: Lung cancer, specifically non-small cell lung cancer (NSCLC), is a leading cause of cancer-related mortality worldwide. TP53, a crucial tumor suppressor gene, is often mutated in various cancers, including l...
Safia Fathima Anver Pasha,Tasnim Fathima Khalifa Anver,Suresh Kumar Srinivasamurthy
Safia Fathima Anver Pasha
Introduction: The discovery of the gene as the primary unit of inheritance marked the beginning of intensive research into targeted genome modifications for treating rare genetic diseases. Despite conventional approaches ...
Harnessing Nanotechnology and Gene Editing for Cancer Therapy: A Synergistic Approach to Precision Medicine [0.03%]
利用纳米技术和基因编辑进行癌症治疗：精准医学的协同方法
Anjana Goel,Istuti Saraswat,Sahaj Sharma et al.
Anjana Goel et al.
The fusion of nanotechnology with gene editing promises a revolutionary strategy in combating cancer, providing the possibility of precise and focused treatments. This review examines the synergistic integration of these two potent technolo...
PAK1 Signaling in Cancer: Multifaceted Roles and Therapeutic Implications [0.03%]
PAK1信号与癌症：多重作用及治疗意义
Faiz Meman,Divya Tandel,Archana Navale
Faiz Meman
PAK1, a serine-threonine kinase, acts as an effector of Rac, Ras, and CDC42, which are pivotal in oncogenic signaling pathways. Its involvement spans critical cellular processes like cell cycle regulation, angiogenesis, and metastasis. PAK1...
Pathogens Association with Alzheimer Disease: Emerging Concepts and New Perspectives [0.03%]
与阿尔茨海默病相关病原体的新概念和新视角
Uma Agarwal,Rajiv Kumar Tonk,Saroj Verma
Uma Agarwal
Alzheimer's Disease (AD) represents a significant global health challenge, distinguished by a complex pathology that involves the accumulation of abnormal proteins in the brain, leading to neuronal loss and brain atrophy. Recent research ha...
Association of KIM-1 (HAVCR1) Expression with the Tumor Immune Microenvironment in Clear Cell Renal Cell Carcinoma [0.03%]
基底细胞肾癌中KIM-1(HAVCR1)表达与肿瘤免疫微环境的相关性
Panagiotis J Vlachostergios,Athanasios Karathanasis,Foteini Karasavvidou et al.
Panagiotis J Vlachostergios et al.
Introduction: Kidney injury molecule 1 (KIM-1) is a cell-surface glycoprotein expressed in the proximal tubules and encoded by the hepatitis A virus cellular receptor 1 (HAVCR1) gene. It is also expressed in renal cell ca...
DrugSurvPlot: A Novel Web-Based Platform Harnessing Drug Sensitivity Scores as Molecular Biomarkers for Pan-Cancer Survival Prognosis [0.03%]
DrugSurvPlot：一种新颖的基于网络的平台，利用药物敏感性评分作为分子生物标志物进行泛癌症预后分析
Ying Shi,Qirui Shen,Aimin Jiang et al.
Ying Shi et al.
Background: Using predicted drug sensitivity scores as survival biomarkers may improve precision medicine and overcome the limitations of genomically guided approaches in clinical trials. ...
Genomic Medicine: A Critical Review of its Impact on Diagnosing and Treating Genetic Disorders [0.03%]
基因组医学：其在遗传性疾病诊断和治疗方面的影响批判性评述
Vickram Sundaram,Sindhu Kaviya Rengarajan,Sivasubarmanian Manikandan et al.
Vickram Sundaram et al.
Genomic medicine is revolutionizing genetic disease diagnosis and therapy; has a major impact on clinical practice, particularly in diagnosis and treatment. In addition, next-generation sequencing (NGS) has transformed diagnostics. These ad...
The Mitochondrial Deoxyribonucleic Acid Puzzle: Controversies, Challenges, and Critical Perspectives - A Narrative Review [0.03%]
线粒体脱氧核糖核酸之谜：争议、挑战与批判性视角——综述文章
Naina Kumar,Mishu Mangla
Naina Kumar
Human mitochondrial DNA (mtDNA) stands at the nexus of scientific intrigue and controversy, owing to its distinctive genetic features and indispensable role in cellular energy dynamics. This narrative review explores the complexities, contr...