MARVELD3 as a Prognostic Biomarker in Esophageal Cancer and its Relationship with m6A Modification, Cuproptosis, and the ceRNA Regulatory Network [0.03%]
MARVD3在食管癌中的预后标志物作用及其与m6A修饰、铜死亡和ceRNA调控网络的关系
Wenbo Fan,Chunyao Huang,Zhulin Wang et al.
Wenbo Fan et al.
Introduction: The present study analyzed the specific function of MARVEL domaincontaining protein 3 (MARVELD3) in esophageal cancer (EC). Methods: ...
Tushar Verma,Ravi Pratap Singh,Mahima Chaudhary et al.
Tushar Verma et al.
Introduction: Cardiovascular diseases continue to be the leading cause of death worldwide. Traditional medicines relieve symptoms and slow the advancement of the disease, but fail to fix genetic problems at their roots. C...
Advancing siRNA Therapeutics with Pharmacometrics: A Review of Modeling Approaches and Clinical Applications [0.03%]
基于药动学的siRNA药物治疗研究进展：模型方法与临床应用综述
Jueun Kang,Hyeonwoo Yim,Hyunsuk Jeong et al.
Jueun Kang et al.
Small interfering RNA (siRNA) therapeutics represent a paradigm shift in targeting previously undruggable diseases through specific gene silencing. Since the FDA's first approval of patisiran in 2018, the field has expanded rapidly, with ei...
Identifying Basement Membrane-Related Diagnostic Biomarkers for Rheumatoid Arthritis Through Machine Learning [0.03%]
基于机器学习的类风湿性关节炎基底膜相关诊断生物标志物识别
Lingtian Min,Chengji Zhang,Long Xu et al.
Lingtian Min et al.
Introduction: Rheumatoid Arthritis (RA) is a common autoimmune disease. The Basement Membrane (BM) plays a critical structural role in tissues such as the kidneys and joints, and is often implicated in immune-related dise...
A Multi-Gene Myofibroblast Framework Stratifies Prognostic and Immune Landscapes in HCC [0.03%]
一个多基因肌纤维母细胞框架划分HCC的预后和免疫景观
Li Bai,Qingmiao Shi,Leiya Fu
Li Bai
Introduction: Myofibroblasts play a critical role in the progression of hepatocellular carcinoma (HCC), a major subtype of primary liver cancer. Methods: ...
Single-cell Transcriptomics Inference of Neutrophil-mast Cell Communication Programs in Periodontitis [0.03%]
单细胞转录组学推理出牙周炎中性粒细胞-肥大细胞通讯程序
Lina Liu,Miaomiao Xue
Lina Liu
Introduction: Neutrophil dysregulation is one of the main features of periodontitis (PD). This study delineated neutrophil heterogeneity and predicted potential communication of mast cells within the microenvironment of P...
GULP1 in Ovarian Cancer: Expression, Biological Function, and Clinical Significance [0.03%]
卵巢癌中的GULP1：表达、生物学功能和临床意义
Zongzong Sun,Xinjun Hu,Di Huang et al.
Zongzong Sun et al.
Introduction: As an engulfment adapter for apoptotic clearance, GULP1 is related to tumor progression, but its role in ovarian cancer (OVCA) remains unclear. ...
Single‑cell Transcriptomic Profiling of Bone Marrow Mesenchymal Stem Cells Reveals Lineage Heterogeneity and Dysregulated Osteoblast Genes in Osteoporosis Versus Osteoarthritis [0.03%]
单细胞转录组分析骨髓间充质干细胞揭示了骨质疏松症和骨关节炎中成骨细胞基因的异质性及失调状况
Houlei Wang,Chenyang Zhuang,Tianle Ma et al.
Houlei Wang et al.
Introduction: Osteoporosis (OP) and osteoarthritis (OA) are two skeletal disorders characterized by disrupted bone homeostasis. Transplantation of bone marrow mesenchymal stem cells (BM-MSCs) has emerged as a promising th...
Surface Functionalization of 3D-Printed Porous Ti-6Al-4V Scaffolds with PDA‑mHA-Col I Composite Coating Drives Macrophage Polarization toward the M2 Phenotype and Promotes Immunomodulation: An In Vitro Study [0.03%]
基于PDA-mHA-Col I复合涂层的功能化3D打印多孔Ti-6Al-4V支架驱动巨噬细胞极化为M2表型并促进免疫调节：体外研究
Xu Han,Hailong Yuan,Yi Xiao et al.
Xu Han et al.
Objective: To devise a bioactive surface functionalization approach for 3D-printed Ti- 6Al-4V scaffolds that influences macrophage polarization towards the pro-reparative M2 phenotype, therefore enhancing immunomodulation...
Screening and Functional Study of Biomarkers Related to Cell-in-cell Structure in Stomach Adenocarcinoma [0.03%]
胃腺癌细胞内包涵体相关生物标志物的筛选及功能研究
Xiangjie Fang,Xinyu Gu,Dong Hou et al.
Xiangjie Fang et al.
Introduction: A comprehensive study of Cell-In-Cell (CIC) structures in stomach adenocarcinoma (STAD) may facilitate the development of therapeutic strategies. ...