Gautham Chengizkhan,Arumugam Rajavelu,Sridhar Muthusami et al.
Gautham Chengizkhan et al.
Cancer remains one of the leading causes of death worldwide, and the limitations of conventional therapies such as surgery, chemotherapy, and radiotherapy underscore the urgent need for innovative therapeutic strategies. While advances in e...
SPTSSA in Head and Neck Squamous Cell Carcinoma: Prognostic Significance and Implications for Gene- and Cell-Based Therapy [0.03%]
Zihao Zhang,Wei Zhang,Mingming Tang et al.
Zihao Zhang et al.
Objective: The Tumor Microenvironment (TME) exerts a pivotal regulatory effect on the initiation, progression, and therapeutic response of Head and Neck Squamous Cell Carcinoma (HNSCC). Serine Palmitoyltransferase Small S...
Shaping the Future of Prostate Cancer Care: The Promise and Pitfalls of Gene- and Cell-Based Therapeutics [0.03%]
塑造前列腺癌护理的未来：基因和细胞治疗的前景与挑战
Dherya Guleria,Navjot Kaur Sandhu
Dherya Guleria
Prostate Cancer (PCa) affects the population worldwide on a large scale in men. This paper presents a comprehensive overview of the evolving therapeutic landscape for PCa and highlights the promise and challenges of gene- and cell-based str...
Transcription Factor EB Drives Thrombospondin-1 Expression to Dampen Focal-adhesion Signaling and Limit Post-infarction Cardiac Fibrosis [0.03%]
转录因子EB通过驱动血影蛋白-1表达来抑制焦黏附信号传导并限制心梗后心脏纤维化
Cong Liu,Qiang Zhang,Dawang Zhou et al.
Cong Liu et al.
Background: Cardiac fibroblasts (CFs) are essential for cardiac morphogenesis and homeostasis. We investigated whether transcription factor EB (TFEB) directly targeted and suppressed the activation of CFs, aiming to eluci...
CFTR mRNA-Based Gene Therapy for Cystic Fibrosis: A Mutation-Agnostic Strategy to Restore Ion Transport Function [0.03%]
用于囊性纤维化的CFTR mRNA基基因疗法：一种恢复离子转运功能的突变无关策略
Jayendra Kumar,Mehetre Dattatraya Martand,Arpan Kumar Tripathi et al.
Jayendra Kumar et al.
Cystic fibrosis is a severe autosomal recessive disorder caused by mutations in the CFTR gene, leading to dysfunctional chloride ion transport across epithelial cells. This results in the accumulation of thick, sticky mucus, primarily affec...
Decoding Programmed Cell Death Genes: Innovations in Cancer Diagnosis and Treatment [0.03%]
解读程序性细胞死亡基因：癌症诊断和治疗的创新方法
Aman Kumar,Balak Das Kurmi
Aman Kumar
Programmed cell death (PCD) profoundly influences cancer initiation, progression, and therapeutic response through interconnected pathways such as apoptosis, autophagy, ferroptosis, necroptosis, and pyroptosis. This perspective summarizes r...
Vatan Chaudhary,Atul Pratap Singh,Himanchal Sharma et al.
Vatan Chaudhary et al.
Introduction: CRISPR-Cas9 enables precise genome editing but faces delivery challenges, including poor cellular uptake, off-target effects, and immune activation. Focused ultrasound (FUS) and nanotechnology-based carriers...
Challenges in the Stability, Safety, and Efficacy of Antisense Oligonucleotide Therapeutics [0.03%]
反义寡核苷酸药物的稳定性、安全性和有效性的挑战分析
Mohini Santosh Jamadade,Rashmi Bhushan,Sakshi Ramesh Mahadik et al.
Mohini Santosh Jamadade et al.
Antisense oligonucleotides represent a promising class of therapeutic agents due to their high specificity in modulating gene expression. These short, single-stranded synthetic sequences (typically 13-25 nucleotides) function by binding to ...
Gene Therapy for Hemophilia: Innovations, Milestones, and Future Prospects [0.03%]
遗传性血友病的基因治疗：创新、里程碑和未来前景
Dinesh Kumar,Vrinda Gupta,Rajni Tanwar et al.
Dinesh Kumar et al.
Haemophilia, a genetic bleeding disorder predominantly affecting males, arises from deficiencies or dysfunctions in clotting factors VIII or IX. Conventional treatments, such as frequent intravenous infusions of clotting factor concentrates...
Exploring the Epigenetic Mechanisms Underlying Chronic Diseases: A Comprehensive Review [0.03%]
探究慢性疾病表观遗传机制：综述性研究
Afaf Aldahish,Rajalakshimi Vasudevan,Shaima Y Al Qasim et al.
Afaf Aldahish et al.
Epigenetics, the study of heritable changes in gene expression without changes to the DNA sequence, has emerged as an important regulator of disease risk and development. Epigenetic alterations, such as DNA methylation, histone modification...