PROTAC-Mediated Targeting of PARP via CRBN: Mechanistic Insights, Resistance Challenges, and Therapeutic Advancements [0.03%]
基于CRBN介导的PARP靶向(PROTAC)：机制见解、抗性挑战及治疗进展
Hannah Lalengzuali Fanai,Basuvan Babu,Kalirajan Rajagopal et al.
Hannah Lalengzuali Fanai et al.
Proteolysis-targeting chimeras (PROTACs) have become a game-changing mode of therapeutic intervention capable of turning off disease-driving proteins by using the ubiquitinproteasome system. In contrast to conventional inhibitors, PROTACs a...
Recent Advancements in the Development of Heterocyclic Scaffolds as Potential Anti-cancer Agents Targeting EGFR and VEGFR-2 [0.03%]
近年异环支架作为潜在的抗癌药物作用于表皮生长因子受体和血管内皮生长因子受体-2的研究进展
Vindhya Aggarwal,Saurabh Sharma,Apurva Mishra et al.
Vindhya Aggarwal et al.
The Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Receptor (VEGFR) families are among the key oncogenic receptors targeted for developing safe and effective drug therapies for cancer. Upon activation, these ...
Exploring the Anticancer Potential of Synthetic β-Carboline Derivatives: A Comprehensive Systematic Review [0.03%]
合成β-咔啉衍生物抗肿瘤潜力的系统评价研究报告
Aloke Saha,Kakali Bhadra
Aloke Saha
Introduction: Cancer remains a formidable global challenge, necessitating continuous exploration of innovative therapeutic avenues. Synthetic β-carboline derivatives have emerged as promising candidates with notable anti...
KIF20A in Human Malignancies: Oncogenic Mechanisms and Therapeutic Targeting Strategies [0.03%]
人恶性肿瘤中KIF20A的致癌机制及靶向策略研究进展
Zhi Li,Shujiang Wang,Yonghao OuYang et al.
Zhi Li et al.
KIF20A is a key member of the kinesin family and is indispensable for the mitotic process. It governs cytokinesis, spindle dynamics, and centrosome integrity. KIF20A is frequently overexpressed in diverse human cancers, including pancreatic...
Phytocompound-loaded Biomaterial-based Scaffolds: Emerging Strategies for Wound Healing Applications [0.03%]
负载植物化合物的生物材料基支架：伤口愈合应用的新兴策略
Akchayaa Karthikeyan,Angel Eden,Adithi Dileep et al.
Akchayaa Karthikeyan et al.
For effective wound healing, controlled inflammation, vascularization, and the deposition of an organized extracellular matrix are required. Scaffold-based therapies serve as a promising approach in wound healing applications, and they act ...
Bioprospecting of Natural Products as Sources of New Multitarget Therapies [0.03%]
生物勘探：天然产物作为新型多靶标药物来源的潜力
Marcello Iriti
Marcello Iriti
Boosting the Functional Potential of Pectin: Recent Progress in Antimicrobial Applications through Structural Modifications (2020-2025) [0.03%]
果胶功能潜力的提升：通过结构修饰增强抗菌应用的近期进展（2020-2025）
Mohammed Sanad Alhussaini,AbdulRahman Abdulla Ibrahim Alyahya,Abdullah Abdulrahman Al-Ghanayem
Mohammed Sanad Alhussaini
Biopolymers have garnered increasing attention in recent years due to their biodegradability, renewability, and functional versatility, making them ideal candidates for various biomedical, food, and environmental applications. Among these, ...
Pharmacological Potential of Achillea millefolium: A Review of Its Anti-inflammatory, Antioxidant, Antispasmodic, and Antimicrobial Properties [0.03%]
牻牛儿苗的药理潜力：对其抗炎、抗氧化、解痉和抗菌性能的综述
Ayushi Sanguri,Sumitra Nain
Ayushi Sanguri
Achillea millefolium, a perennial herb, is commonly found in Europe and Asia, particularly in the Northern Hemisphere. It is a member of the Asteraceae family, the Achillea genus, and the kingdom Plantae. Due to its wide range of pharmacolo...
Triazolopyridazines as Privileged Heterocyclic Scaffolds: Advances in Synthesis, Structure- Activity Relationship and Therapeutic Applications [0.03%]
三唑并吡啶
Eman A El-Khouly,Eman M Ahmed,Madiha K El-Sobky et al.
Eman A El-Khouly et al.
The pursuit of effective cancer treatment with high specificity and minimal side effects remains crucial for improving human health. Compounds containing triazolopyridazine scaffolds have garnered significant interest among researchers due ...
Pyrithione: A Privileged Structure with the Essential Pharmacophore for Inhibiting Zinc Metalloenzymes [0.03%]
吡啶硫酮：抑制锌金属酶的关键药效团的骨架结构
Woo Shik Shin,Sadia Zafar,Taylor Scott Kuebler et al.
Woo Shik Shin et al.
Zinc Pyrithione is a naturally occurring zinc complex well-known as an antifungal agent, used in the treatment of dandruff and other scalp-related diseases for more than half a century. Pyrithione has been exploited as a potential antimicro...