A Comprehensive Update on the Anti-cancer and Anti-microbial Potential of Marine Organisms Derived Natural Products [0.03%]
来自海洋生物的天然产物抗癌和抗微生物潜力的全面更新
Yash Kothari,Saikat Sasmal,Abhishek Suman et al.
Yash Kothari et al.
Marine organisms produce a diverse array of secondary metabolites with significant pharmacological potential, particularly in the development of anti-cancer, anti-microbial, antifungal, and anti-viral therapies. Despite challenges in isolat...
Research Progress on Targeted Inhibition of Ferroptosis and Alzheimer's Disease Treatment [0.03%]
靶向抑制铁死亡和阿尔茨海默病治疗研究进展
Annan Liu,Jianhui Li,Wei Gao et al.
Annan Liu et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the formation of senile plaques and neurofibrillary fiber tangles. Studies have shown that increased regional iron loading in the brain, dysregulation of i...
Critical Relationship Between Iron Deficiency Anaemia (IDA) and Glycated Haemoglobin (HbA1c): An Updated Review [0.03%]
铁缺乏性贫血(IDA)与糖化血红蛋白(HbA1c) critical关系的最新综述
Ibrahim Mahmood,Ammar Hamza,Shazrul Fazry et al.
Ibrahim Mahmood et al.
Introduction: This review explores the complex relationship between Iron Deficiency Anaemia (IDA) and glycated haemoglobin (HbA1c) levels, a critical marker for diabetes mellitus. The objective is to evaluate how IDA infl...
Research Hotspots and Trends of Artificial Intelligence in Drug Discovery: A Review and Bibliometric Analysis [0.03%]
人工智能在药物发现中的研究热点和趋势：综述与文献计量分析
Jiefu Qu,Shangyu Ju,Mengjie Zhang et al.
Jiefu Qu et al.
The drug discovery process is highly intricate and complex. Driven by unprecedented advances in AI technology, the application of artificial intelligence in drug discovery (AIDD) is showing significant growth, and AIDD has the potential to ...
Dau Ram,Chandrabose Karthikeyan,Pranay Soni et al.
Dau Ram et al.
The method of discovering new drugs is costly, time-consuming, laborious, and associated with a high failure rate. Various techniques have been applied in modern drug discovery to resolve these issues and discover novel pharmacologically ac...
A Mini Review on Metal Complexes as Potential Anti-SARS-CoV-2 Agents: Insights from Molecular Docking Studies [0.03%]
金属配合物作为潜在的抗SARS-CoV-2剂的迷你评论：来自分子对接研究的启示
Endamuri Sai Vineeth,Smit Saha,Venkata Bharat Nishtala
Endamuri Sai Vineeth
There is an urgent need to develop effective antiviral treatments against SARS-CoV-2. Despite the availability of vaccines, drug discovery remains critical for combating emerging variants. Molecular docking studies have become a vital compu...
Khadija Younas,Ashiq Ali,Aisha Khatoon et al.
Khadija Younas et al.
In the ongoing battle between the immune system and cancer, a unique subset of T cells has quietly emerged as a key player. Tissue-Resident Memory T (TRM) cells, strategically positioned within tissues, are redefining our understanding of l...
Human P53 Expression in Yeast: Investigating Its Apoptotic Effects [0.03%]
人p53在酵母中的表达及其诱导细胞凋亡作用的初步研究
Sihem Ben Abid,Wafa Mihoubi,Ines Yacoubi et al.
Sihem Ben Abid et al.
Since its discovery in 1979, the tumor suppressor p53 has been widely studied and expressed in various organisms, including yeast. Yeast has proven to be a very informative model and an effective system for studying the roles and functions ...
Nanotechnology Meets Phytotherapy: A Comprehensive Review of Berberine in Cancer [0.03%]
纳米技术与植物药理学的结合：巴马汀在癌症中的综合评论
Istuti Saraswat,Anjana Goel,Jyoti Gupta
Istuti Saraswat
Cancer continues to pose a worldwide health concern, requiring breakthrough therapeutic approaches that are both efficacious and minimally intrusive. Berberine, a natural isoquinoline alkaloid, has attracted considerable interest due to its...
Unraveling the Multifunctional Therapeutic Potential of Topsentin: A Marine-derived Versatile Scaffold [0.03%]
揭秘拓普森丁的多功能治疗潜力：一种具有多种功能的海洋衍生支架分子
Navin Kumar Tailor,Sandeep Kumar Singh
Navin Kumar Tailor
Natural products (NPs) have long served as a rich inspirational source for drug discovery and development, offering diverse chemical structures and biological activities. Among these, topsentin, a marine alkaloid derived from marine sponges...