PROTAC-Mediated Targeting of PARP via CRBN: Mechanistic Insights, Resistance Challenges, and Therapeutic Advancements
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Proteolysis-targeting chimeras (PROTACs) have become a game-changing mode of therapeutic intervention capable of turning off disease-driving proteins by using the ubiquitinproteasome system. In contrast to conventional inhibitors, PROTACs act through event-dri... ...