Functionalized Imidazo[1,2-a]pyridine-3-yl Scaffolds: Synthetic Strategies and Anticancer Potential Agent [0.03%]
功能化咪唑并[1,2-a]吡啶-3-基骨架：合成策略及抗肿瘤活性研究
Edgar Eduardo Aguilar-Campos,Fabiola Noemí de la Cruz-Durán,Catalina María Pérez Berumen
Edgar Eduardo Aguilar-Campos
The imidazo[1,2 a]pyridine scaffold has emerged as a highly versatile platform in medicinal chemistry, attracting increasing attention due to its relevance in oncology. Over the past decade, significant progress has been made in the develop...
Micro/Nanomotors and Synthetic Polymers: Pioneering New Approaches for Antimicrobial Therapy [0.03%]
微纳马达和合成聚合物：抗菌治疗的新方法
Manaf AlMatar,Osman Albarri,Imen Ben Abdelmalek
Manaf AlMatar
Antibiotic-resistant bacteria that cause diseases are one of the greatest threats facing people's lives around the globe because of the abuse of antibiotics. Due to increasing resistance, antibiotics are becoming less effective. Therefore, ...
Enhancing Cancer Patient Outcomes using Theranostic Nanomedicine: Advances, Challenges, and Future Prospects [0.03%]
利用诊疗纳米药物增强癌症患者疗效：进展、挑战与前景展望
Bhavya E,Vivekanandan K,Pradeep K et al.
Bhavya E et al.
Theranostic nanomedicine integrates diagnostic and therapeutic functions into a single nanoparticle, allowing clinicians to image a tumor and treat it with the same agent. The logic is simple: instead of administering separate compounds to ...
Artificial Intelligence-enhanced Cannabidiol (CBD) Drug Delivery Systems: Integrating Machine Learning and Nanotechnology for Precision Therapeutic Optimization [0.03%]
人工智能增强的大麻二酚（CBD）药物递送系统：集成机器学习和纳米技术以实现精准治疗优化
Khushi Dahiya,Shikha Baghel Chauhan,Indu Singh et al.
Khushi Dahiya et al.
As a conceptual framework to address the well-documented pharmacokinetic and formulation problems of Cannabidiol (CBD), the integration of AI into CBD drug delivery research is being investigated. With a focus on theoretical potential rathe...
Exploring the Therapeutic Potential of Chalcones in Alzheimer's Disease: Mechanistic Insights and SAR Perspectives [0.03%]
查尔康因在阿尔茨海默病治疗潜力的探索：机制见解和结构活性关系视角
Deepika Paliwal,Aman Thakur
Deepika Paliwal
Alzheimer's disease is a multifactorial neurodegenerative disorder characterized by amyloid- β aggregation, oxidative stress, neuroinflammation, tau hyperphosphorylation, and cholinergic dysfunction. The limited efficacy of current therapi...
Aptamer-carbon Nanotube Hybrids: Emerging Frontiers in Biomedical Diagnostics and Therapeutics [0.03%]
适配体-碳纳米管混合物在生物医学诊断和治疗中的新兴前沿领域研究
Rohit R Bhosale,Sarika J Patil,Satwashila S Kadam et al.
Rohit R Bhosale et al.
Aptamers are single-stranded DNA or RNA molecules that exhibit remarkable affinity and specificity for a broad spectrum of biological targets, positioning them as compelling alternatives to antibodies in both diagnostics and therapeutics. T...
Computational Drug Repurposing: Exploring New Uses for Existing Molecules in the Treatment of Diabetes Mellitus [0.03%]
计算药物再利用：探索已知分子在糖尿病治疗中的新用途
S Mahirah,N Harikrishnan,Viswas Raja Solomon
S Mahirah
The computational method of drug discovery is making remarkable, revolutionary changes in the identification and development of new drugs. Drugs already on the market with a claimed therapeutic application are repurposed for other major app...
PARP1 as a Central Node in DNA Repair and Epigenetic Regulation: Implications for Biomarker Discovery and Targeted Therapy in NSCLC [0.03%]
PARP1在DNA修复和表观遗传调控中的核心作用：对NSCLC生物标志物发现和靶向治疗的意义
Muskan Sharma,Gowramma Byran,Hardha Balachandran et al.
Muskan Sharma et al.
Introduction: PARP1 is a key regulator of genome integrity, DNA repair, and epigenetic control. PARP inhibitors (PARPis), designed as nicotinamide mimetics that target the NAD⁺ binding pocket, exploit synthetic lethality...
Molecular and Cellular Pathways and Mechanisms of Antioxidant Compounds Against Oxidative Stress in Obesity-associated Male Infertility: A Comprehensive Review [0.03%]
抗氧化化合物通过分子和细胞途径及机制对抗肥胖相关男性不育氧化应激的综合述评
Fani-Niki Varra,Panagiotis Theodosis-Nobelos,Viktoria-Konstantina Varra et al.
Fani-Niki Varra et al.
Obesity is a condition characterized by abnormal or excessive fat accumulation that increases the risk of various health conditions. Obesity is highly linked to reduced male fertility parameters, including semen volume, sperm count and conc...
From Chemistry to Clinic: A Review of Latanoprostene Bunod and Its Therapeutic Potential [0.03%]
从化学到临床：拉坦前列腺素布诺酯及其治疗潜力综述
Biswa Deepak Bharati,Rani Mansuri,Anupama Diwan et al.
Biswa Deepak Bharati et al.
Open-Angle Glaucoma (OAG) is a progressive optic neuropathy and a major cause of irreversible blindness worldwide. Lowering Intraocular Pressure (IOP) remains the most effective approach for slowing disease progression. Latanoprostene bunod...