PARP1 as a Central Node in DNA Repair and Epigenetic Regulation: Implications for Biomarker Discovery and Targeted Therapy in NSCLC
{{output}}
Introduction: PARP1 is a key regulator of genome integrity, DNA repair, and epigenetic control. PARP inhibitors (PARPis), designed as nicotinamide mimetics that target the NAD⁺ binding pocket, exploit synthetic lethality in homo... ...
