Discovery of novel limonin derivatives as potent anti-inflammatory and analgesic agents [0.03%]
新型柠檬素衍生物抗炎镇痛剂的发现
Shao-Chi Wang,Yun Yang,Jing Liu et al.
Shao-Chi Wang et al.
Novel series of limonin derivatives (V-A-1-V-A-8, V-B-1-V-B-8) were synthesized by adding various tertiary amines onto the C (7)-position of limonin. The synthesized compounds possessed favorable physicochemical property, and the intrinsic ...
Sedative and antinociceptive activities of two new sesquiterpenes isolated from Ricinus communis [0.03%]
从中麻疯树中分离得到的两种新的倍半萜的镇静和止痛作用
Umar Farooq,Ajmal Khan,Sadia Naz et al.
Umar Farooq et al.
Two new sesquiterpenes, trivially named ricinusoids A (1) and ricinusoids B (2), were isolated from ethyl acetate fraction of Ricinus communis. The structures of new compounds were elucidated by detailed spectroscopic techniques, including ...
Antioxidant xanthones and anthraquinones isolated from a marine-derived fungus Aspergillus versicolor [0.03%]
来源于海洋真菌Aspergillus versicolor中的抗氧化型茋和蒽醌类化合物
Ze-Hong Wu,Dong Liu,Ying Xu et al.
Ze-Hong Wu et al.
Chemical examination of an EtOAc extract of cultured Aspergillus versicolor fungus from deep-sea sediments resulted in the isolation of four xanthones, eight anthraquinones and five alkaloids, including a new xanthone, oxisterigmatocystin D...
Construction of a mutant of Actinoplanes sp. N902-109 that produces a new rapamycin analog [0.03%]
产生新型雷帕霉素类似物的链霉菌N902-109突变体的构建
He Huang,Ping Gao,Qi Zhao et al.
He Huang et al.
In the present study, we introduced point mutations into Ac_rapA which encodes a polyketide synthase responsible for rapamycin biosynthesis in Actinoplanes sp. N902-109, in order to construct a mutant with an inactivated enoylreductase (ER)...
Brazilin and Caesalpinia sappan L. extract protect epidermal keratinocytes from oxidative stress by inducing the expression of GPX7 [0.03%]
巴西苏木提取物通过诱导GPX7表达保护角质细胞免受氧化应激损伤
Hyung Seo Hwang,Joong Hyun Shim
Hyung Seo Hwang
Caesalpinia sappan L., belonging to the family Leguminosae, is a medicinal plant that is distributed in Southeast Asia. The dried heartwood of this plant is used as a traditional ingredient of food, red dyes, and folk medicines in the treat...
Buyang Huanwu Decoction ameliorates ischemic stroke by modulating multiple targets with multiple components: In vitro evidences [0.03%]
补阳还五汤通过多成分、多目标改善缺血性卒中的体外证据
Wei-Wei Zhang,Feng Xu,Ding Wang et al.
Wei-Wei Zhang et al.
Buyang Huanwu Decoction (BYHWD) is a well-known traditional Chinese medicine prescription which is used to treat ischaemic stroke and stroke-induced disabilities. However, the exact mechanism underlying BYHWD's amelioration of ischaemic str...
Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrier through MMP-9 inhibition and anti-inflammation [0.03%]
天麻苷元A通过抑制基质金属蛋白酶-9和抗炎作用来保护缺血再灌注所致的血脑屏障损伤
Wen Zhang,Jun-Ke Song,Xue Zhang et al.
Wen Zhang et al.
Salvianolic acid A (SAA) is a water-soluble component from the root of Salvia Miltiorrhiza Bge, a traditional Chinese medicine, which has been used for the treatment of cerebrovascular diseases for centuries. The present study aimed to dete...
Qualitative detection of ginsenosides in brain tissues after oral administration of high-purity ginseng total saponins by using polyclonal antibody against ginsenosides [0.03%]
用人参总皂苷多克隆抗体进行口服给药后脑组织中人参皂苷的定性检测
Yu-Nan Zhao,Xiao Shao,Liu-Feng Ouyang et al.
Yu-Nan Zhao et al.
Given the limited studies and conflicting findings, the transport character of ginsenosides crossing the blood-brain barrier (BBB) remains unclear. The present study was designed to qualitatively determine the distribution of ginsenosides i...
Norisoboldine, a natural aryl hydrocarbon receptor agonist, alleviates TNBS-induced colitis in mice, by inhibiting the activation of NLRP3 inflammasome [0.03%]
诺瑞莎_boldine通过抑制NLRP3炎性小体活化治疗TNBS诱导的小鼠结肠炎研究
Qi Lv,Kai Wang,Si-Miao Qiao et al.
Qi Lv et al.
Although the etiology of inflammatory bowel disease is still uncertain, increasing evidence indicates that the excessive activation of NLRP3 inflammasome plays a major role. Norisoboldine (NOR), an alkaloid isolated from Radix Linderae, has...
Bamboo salt suppresses skin inflammation in mice with 2, 4-dinitrofluorobenzene-induced atopic dermatitis [0.03%]
竹盐通过口服或外用可抑制2,4-二硝基氟苯诱导的小鼠特应性皮炎炎症反应
Myoung-Schook Yoou,Sun-Young Nam,Kyoung Wan Yoon et al.
Myoung-Schook Yoou et al.
Bamboo salt (BS) is a traditional Korean food, and has been reported to have anti-cancer, anti-inflammatory, and anti-metastatic effects. However, the anti-atopic dermatitis (AD) activity of BS has not been described yet. In the present stu...