Construction of a mutant of Actinoplanes sp. N902-109 that produces a new rapamycin analog
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In the present study, we introduced point mutations into Ac_rapA which encodes a polyketide synthase responsible for rapamycin biosynthesis in Actinoplanes sp. N902-109, in order to construct a mutant with an inactivated enoylreductase (ER) domain, which was a... ...
