Cardiovascular risk factors in portuguese obese children and adolescents: impact of small reductions in body mass index imposed by lifestyle modifications [0.03%]
葡萄牙肥胖儿童和青少年心血管疾病风险因素：生活方式改变导致的体质指数微小降低带来的影响
Henrique Nascimento,Elísio Costa,Petronila Rocha-Pereira et al.
Henrique Nascimento et al.
Objectives: Evaluate cardiovascular risk factors in Portuguese obese children and adolescents and the long-term effects of lifestyle modifications on such risk factors. ...
Hypothetical two-step initiation of experimental carcinogenesis by polycyclic aromatic hydrocarbons and aminoazo dyes [0.03%]
多环芳烃和氨基偶氮染料实验癌变的假两步启动机制研究
Bodo Contag
Bodo Contag
A new hypothesis is discussed, which describes the initiation of the carcinogenesis through polycyclic aromatic hydrocarbons (PAHs) and aminoazo dyes (AZOs) as a two-step process: the oncogenic proteins of the ras or ras-like on-cogenes act...
Effects of nerve growth factor and nitric oxide synthase inhibitors on amyloid precursor protein mRNA levels and protein stability [0.03%]
神经生长因子和一氧化氮合酶抑制剂对淀粉前体蛋白mRNA水平及蛋白稳定性的效应
Janet C Mackinnon,Patricia Huether,Bettina E Kalisch
Janet C Mackinnon
We determined previously that nitric oxide (NO) modulates the nerve growth factor (NGF)-mediated increases in amyloid precursor protein (APP) levels in PC12 cells. To elucidate potential mechanisms, the effects of NGF and NO synthase (NOS) ...
Protein Kinase A Subunit α Catalytic and A Kinase Anchoring Protein 79 in Human Placental Mitochondria [0.03%]
人类胎盘线粒体中的蛋白激酶A亚基α催化和蛋白激酶锚定蛋白质79
Maggie Pui Chi Ma,Murray Thomson
Maggie Pui Chi Ma
Components of protein phosphorylation signalling systems have been discovered in mitochondria and it has been proposed that these molecules modulate processes including oxidative phosphorylation, apoptosis and steroidogenesis. We used elect...
Effects of α-Particle Radiation on MicroRNA Responses in Human Cell-Lines [0.03%]
α粒子辐射对人细胞系中MicroRNA反应的影响
Vinita Chauhan,Matthew Howland,Ruth Wilkins
Vinita Chauhan
A variety of alpha (α)-particle emitters are found ubiquitously in the environment, in commercial/therapeutic prod-ucts and are a potential threat in the form of a radiological dispersal device. Our understanding of the biological mechanis...
Gossypol Inhibits Electron Transport and Stimulates ROS Generation in Yarrowia lipolytica Mitochondria [0.03%]
格尔迪波因抑制电子传递并促进耶拉氏假丝酵母线粒体ROS生成
Anna Yu Arinbasarova,Alexander G Medentsev,Vladimir I Krupyanko
Anna Yu Arinbasarova
This work studied the effect of gossypol on the mitochondrial respiratory chain of Yarrowia lipolytica. The compound was shown to inhibit mitochondrial electron transfer and stimulate generation of reactive oxygen species. The inhibition ki...
Endoplasmic Reticulum (ER) Stress Enhances Tip60 (A Histone Acetyltransferase) Binding to the Concanavalin A [0.03%]
内质网应激增强Tip60（组蛋白乙酰转移酶）与刀豆蛋白A的结合
Eun Jeoung Lee,Sung Hwa Shin,Sunghee Hyun et al.
Eun Jeoung Lee et al.
Herein, we report that the concanavalin A binding of Tip60 (a target of the human immunodeficiency virus type 1-encoded transactivator Tat interacting protein 60 KD; a histone acetyltransferase; HAT) is enhanced as the result of endoplasmic...
Distinct metal ion requirements for the phosphomonoesterase and phosphodiesterase activities of calf intestinal alkaline phosphatase [0.03%]
钙肠碱性磷酸酶的磷单酯酶和磷二酯酶活性具有不同的金属离子需求
Adedoyin Igunnu,Dunsin S Osalaye,Olufunso O Olorunsogo et al.
Adedoyin Igunnu et al.
The roles of Mg(2+) and Zn(2+) ions in promoting phosphoryl transfer catalysed by alkaline phosphatase are yet to be fully characterised. We investigated the divalent metal ion requirements for the monoesterase and diesterase activities of ...
Carmen Rodríguez-Cerdeira,Alberto Molares-Vila
Carmen Rodríguez-Cerdeira
Background: Oncoproteomics is the study of proteins and their interactions in a cancer cell by proteomic technologies and has the potential to revolutionize clinical practice, including cancer diagnosis. Recent technologi...
Production of free radicals and oxygen consumption by primary equine endothelial cells during anoxia-reoxygenation [0.03%]
马原代血管内皮细胞缺血/再灌注时的自由基生成和耗氧量的研究
Geoffroy de Rebière de Pouyade,Alexandra Salciccia,Justine Ceusters et al.
Geoffroy de Rebière de Pouyade et al.
The endothelium plays an active role in ischemia/reperfusion injuries. Herein, we report the effect of a single or successive cycles of anoxia/reoxygenation (A/R) on the mitochondrial respiratory function of equine endothelial cells (cultur...