The GPCR Antagonistic Drug CM-20 Stimulates Mitochondrial Activity in Human RPE Cells [0.03%]
GPCR拮抗剂CM-20可通过活化AMPK通路促进人视网膜色素上皮细胞线粒体功能
Qing Chang,Siquan Chen,Tahua Yang
Qing Chang
Background: Mitochondrial dysfunction in retinal pigment epithelium (RPE) is a pathogenic factor in age-related macular degeneration (AMD). Improvement of mitochondrial function may ameliorate RPE bioenergetics status, wh...
Co-Administration of Fish Oil With Signal Transduction Inhibitors Has Anti-Migration Effects in Breast Cancer Cell Lines, in vitro [0.03%]
鱼油与信号转导抑制剂联合应用可抑制乳腺癌细胞系的迁移能力：体内研究
Zoë Davison,Robert I Nicholson,Stephen Hiscox et al.
Zoë Davison et al.
Background: There is an urgent need for new therapies to treat cancer metastasis. Fish oil, with high omega 3 fatty acid content, has shown anticancer activity and signal transduction inhibitors have shown anti-metastatic...
RpbL12 Assists Catalysis by Correctly Positioning the Incoming Aminoacyl-tRNA in the A-Site of E. coli 70S Ribosomes [0.03%]
RpbL12通过在E. coli 70S核糖体的A位点正确定位进来的氨酰tRNA来协助催化作用
Jean-Bernard Créchet,Fulbert K Agbo&#x;Saga,Soria Baouz et al.
Jean-Bernard Créchet et al.
Introduction: We have recently demonstrated that Lys-65 of the 62GANK65 motif of E. coli RpbL12 was affinity labeled with a tRNA analogue, resulting in the loss of activity. ...
Testosterone Retention Mechanism in Sertoli Cells: A Biochemical Perspective [0.03%]
生精细胞中睾酮的保留机制——生物化学角度透视
Manjeet Kaur Gill-Sharma
Manjeet Kaur Gill-Sharma
Mechanism(s) involved in regulating Intratesticular Testosterone levels (iT) have assumed importance in recent years, from the point of view of hormonal contraception. Contraceptives using Testosterone (T) in combination with Progestins (P)...
The Clock Genes Are Involved in The Deterioration of Atopic Dermatitis after Day-and-Night Reversed Physical Stress in NC/Nga Mice [0.03%]
时钟基因参与NC/Nga小鼠昼夜颠倒应激诱发特应性皮炎的恶化
Keiichi Hiramoto,Kumi Orita,Yurika Yamate et al.
Keiichi Hiramoto et al.
Background: In modern society, irregular lifestyles are a problem. It is well known that Atopic Dermatitis (AD) occurs during physical stress in people with an irregular lifestyle. We evaluated the influence that day-and-...
Micro-RNAs -106a and -362-3p in Peripheral Blood of Inflammatory Bowel Disease Patients [0.03%]
炎症性肠病患者外周血微小核糖核酸-106a和-362-3p
Ameneh Omidbakhsh,Mohsen Saeedi,Masoud Khoshnia et al.
Ameneh Omidbakhsh et al.
Objective: MicroRNAs (miRNAs) can regulate various genes after binding to target mRNAs. Studies on Inflammatory Bowel Disease (IBD) in relation with miRNA are much less shown. The aim of the present study was to assess th...
Short Exposures to an Extremely Low-Frequency Magnetic Field (ELF MF) Enhance Protein but not mRNA Alkaline Phosphatase Expression in Human Osteosarcoma Cells [0.03%]
极低频磁场（ELF MF）的短期暴露可增强人成骨肉瘤细胞中碱性磷酸酶蛋白表达而非mRNA表达
Tania Rescigno,Anna Capasso,Bruno Bisceglia et al.
Tania Rescigno et al.
Background: Among electromagnetic fields treatments used in orthopedics, extremely low-frequency magnetic fields (ELF MF) need more detailed information about the molecular mechanisms of their effects and exposure conditi...
Tania Rescigno,Mario F Tecce,Anna Capasso
Tania Rescigno
Intoroduction: Dietary intake fundamentally provides reintegration of energy and essential nutrients to human organisms. However, its qualitative and quantitative composition strongly affects individual's health, possibly...
Effects of Glucan and Vitamin D Supplementation on Obesity and Lipid Metabolism in Diabetic Retinopathy [0.03%]
糖葡聚糖和维生素D补充对糖尿病视网膜病变患者肥胖及脂代谢的影响研究
Martina Závorková,Vaclav Vetvicka,Josef Richter et al.
Martina Závorková et al.
Background: Diabetes mellitus is a chronic disease manifested by an increase of blood glucose. Objective: To evaluate the effects of gl...
Delineating Potential Transcriptomic Association with Organochlorine Pesticides in the Etiology of Epithelial Ovarian Cancer [0.03%]
划定潜在转录组与氯丹杀虫剂在上皮性卵巢癌病因学中的关联
Harendra K Shah,Muzaffer A Bhat,Tusha Sharma et al.
Harendra K Shah et al.
Background: Recent studies have shown that there is an increased risk of Epithelial Ovarian Cancer (EOC) with Organochlorine Pesticides (OCPs). However, the alteration in the gene expression profile has not been explored ...